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Cish Gene Detail
Summary
  • Symbol
    Cish
  • Name
    cytokine inducible SH2-containing protein
  • Synonyms
    Cis, CIS1, cytokine-inducible SH2 protein, F23
  • Feature Type
    protein coding gene
  • IDs
    MGI:103159
    NCBI Gene: 12700
  • Gene Overview
    MyGene.info: CISH
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107296659-107302784 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103159
protein coding gene Chr9:107296026-107302784 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035249
protein coding gene Chr9:109152331-109159686 (+)
A/J MGP_AJ_G0035228
protein coding gene Chr9:105191645-105198378 (+)
AKR/J MGP_AKRJ_G0035160
protein coding gene Chr9:107814920-107821652 (+)
BALB/cJ MGP_BALBcJ_G0035222
protein coding gene Chr9:104860896-104867627 (+)
C3H/HeJ MGP_C3HHeJ_G0034932
protein coding gene Chr9:108213557-108220287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035742
protein coding gene Chr9:112153646-112160404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032640
protein coding gene Chr9:102620677-102627626 (+)
CAST/EiJ MGP_CASTEiJ_G0034243
protein coding gene Chr9:108142627-108149386 (+)
CBA/J MGP_CBAJ_G0034900
protein coding gene Chr9:116125816-116132570 (+)
DBA/2J MGP_DBA2J_G0035061
protein coding gene Chr9:104644219-104650967 (+)
FVB/NJ MGP_FVBNJ_G0035009
protein coding gene Chr9:103402796-103409529 (+)
LP/J MGP_LPJ_G0035137
protein coding gene Chr9:109360481-109367214 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035048
protein coding gene Chr9:117715005-117721735 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035763
protein coding gene Chr9:108079069-108085835 (+)
PWK/PhJ MGP_PWKPhJ_G0033950
protein coding gene Chr9:104957891-104964643 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033785
protein coding gene Chr9:108144950-108151706 (+)
WSB/EiJ MGP_WSBEiJ_G0034364
protein coding gene Chr9:107966784-107973523 (+)



Homology
more
  • Human Ortholog
    CISH, cytokine inducible SH2 containing protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CISH, cytokine inducible SH2 containing protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BACTS2, CIS, CIS-1, G18, SOCS
  • Links
    NCBI Gene ID: 1154
    neXtProt AC: NX_Q9NSE2
    UniProt: Q9NSE2

  • Chr Location
    3p21.2; chr3:50606454-50611831 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CISH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced Th2 and Th9 differentiation and allergic airway inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12700 NCBI Gene Model | MGI Sequence Detail 6126 C57BL/6J ±  kb
    transcript NM_009895 RefSeq | MGI Sequence Detail 3014 C57BL/6  
    polypeptide Q62225 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 6
      cDNA 70
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24025, MGI:2143029
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:26494 Yoshimura A, et al., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995 Jun 15;14(12):2816-26
    • Latest
      J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory