About   Help   FAQ
Cish
Gene Detail
 Symbol
Name
ID
Cish
cytokine inducible SH2-containing protein
MGI:103159
Synonyms Cis, CIS1, cytokine-inducible SH2 protein, F23
Feature Type protein coding gene
Genetic Map
Chromosome 9
57.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:107296026-107302784 bp, + strand
From VEGA annotation of GRCm38

  6759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7667  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: suppressor of cytokine signaling (SOCS) 1-3
Gene Tree: Cish

Human
homologs
Human Homolog CISH, cytokine inducible SH2-containing protein
NCBI Gene ID 1154
neXtProt AC  NX_Q9NSE2
Human Synonyms  BACTS2, CIS, CIS-1, G18, SOCS
Human Chr (Location)  3p21.3; chr3:50606454-50611831 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CISH
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
 
Mice homozygous for a knock-out allele exhibit enhanced Th2 and Th9 differentiation and allergic airway inflammation.
 
Interactions
Cish interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process intracellular signal transduction, negative regulation of signal transduction, ...
Component plasma membrane
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (1)    Images (3)
Theiler Stages: 23
Assay TypeResults
RNA in situ 3
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) Genomic(6) cDNA(68) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036835 (Evidence)
Ensembl Gene ModelENSMUSG00000032578 (Evidence)
Entrez Gene12700 (Evidence)
UniGene4592
DFCITC1575404
DoTSDT.533166, DT.91286955
Consensus CDS ProjectCCDS40761.1
International Mouse Knockout Project StatusCish
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036835 VEGA Gene Model | MGI Sequence Detail 6759 C57BL/6J ±  kb
transcript OTTMUST00000094578 VEGA | MGI Sequence Detail 2850 Not Applicable 
polypeptide OTTMUSP00000052636 VEGA | MGI Sequence Detail 257 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001496 SOCS protein, C-terminal
Protein Ontology PR:000005503 cytokine-inducible SH2-containing protein
References (Earliest) J:26494 Yoshimura A, et al., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995 Jun 15;14(12):2816-26
(Latest) J:204829 Yang XO, et al., The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul;14(7):732-40
All references(49)
Other
accession IDs
MGD-MRK-24025, MGI:2143029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory