Pltp
Gene Detail

Symbol Name ID

Pltp phospholipid transfer protein MGI:103151

Synonyms

Bpife, OD107

Feature Type

protein coding gene

Genetic Map

Chromosome 2

85.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr2:164839518-164857711 bp, - strand From VEGA annotation of GRCm38   18194 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipid-binding protein, LBP type
Gene Tree: Pltp

Human homologs

Human Homolog		PLTP, phospholipid transfer protein
NCBI Gene ID		5360
neXtProt AC		NX_P55058
Human Synonyms		BPIFE, HDLCQ9
Human Chr (Location)		20q13.12; chr20:44527259-44541003 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLTP

Alleles and phenotypes

All alleles(28) : Targeted(1) Gene trapped(27)
 

Mice homozygous for disruptions in this gene have lower levels of circulating HDL and exhibit symptoms of dry eye syndrome such as corneal epithelial damage.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	lipid transport, sperm motility, ...
Component	extracellular region
Function	lipid binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 22

Assay Type	Results
RT-PCR	2

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001168 (Evidence)
Ensembl Gene Model	ENSMUSG00000017754 (Evidence)
Entrez Gene	18830 (Evidence)
DFCI	TC1583034, TC1620036, TC1744133
NIA Mouse Gene Index	U023650
Consensus CDS Project	CCDS17063.1
International Mouse Knockout Project Status	Pltp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001168	VEGA Gene Model | MGI Sequence Detail	18194	C57BL/6J
transcript	OTTMUST00000002266	VEGA | MGI Sequence Detail	2226	Not Applicable
polypeptide	OTTMUSP00000001111	VEGA | MGI Sequence Detail	493	Not Applicable

All sequences(49) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(119 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017943	Bactericidal permeability-increasing protein, alpha/beta domain
InterPro	IPR017954	Lipid-binding serum glycoprotein, conserved site
InterPro	IPR001124	Lipid-binding serum glycoprotein, C-terminal
InterPro	IPR017942	Lipid-binding serum glycoprotein, N-terminal
Protein Ontology	PR:000012888	phospholipid transfer protein

References

(Earliest) J:27216 Jiang XC, et al., Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995 Jul 21;270(29):17133-8
(Latest) J:174122 Bingle CD, et al., Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Biochem Soc Trans. 2011 Aug 1;39(4):977-83
All references(75)

Other accession IDs

MGD-MRK-24017