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Pltp
Gene Detail
Symbol

Name
ID
Pltp
phospholipid transfer protein
MGI:103151
Synonyms
Bpife, OD107
Feature Type
protein coding gene
Genetic Map
Chromosome 2
85.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr2:164839518-164857711 bp, - strand
From VEGA annotation of GRCm38

  18194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLTP
Protein SuperFamily: phospho/glycolipid-binding protein, BPI/LBP type
Gene Tree: Pltp

Human
homologs
PLTP, phospholipid transfer protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5360
neXtProt AC: NX_P55058

Human Synonyms: BPIFE, HDLCQ9

Human Chr (Location): 20q13.12; chr20:45898620-45912364 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLTP

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(27) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene have lower levels of circulating HDL and exhibit symptoms of dry eye syndrome such as corneal epithelial damage.
 
Interactions
Pltp interacts with 25 markers (Mir23b, Mir101a, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process high-density lipoprotein particle remodeling, lipid metabolic process, ...
Component extracellular region, extracellular space
Function lipid binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pltp    NEW 
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001168 (Evidence)
Ensembl Gene Model ENSMUSG00000017754 (Evidence)
Entrez Gene 18830 (Evidence)
DFCI TC1583034, TC1620036, TC1744133
NIA Mouse Gene Index U023650
Consensus CDS Project CCDS17063.1
International Mouse Phenotyping Consortium Status Pltp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001168 VEGA Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript OTTMUST00000002266 VEGA | MGI Sequence Detail 2226 Not Applicable 
polypeptide OTTMUSP00000001111 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
InterPro IPR030675 Lipid binding protein BPI/LBP
InterPro IPR017954 Lipid-binding serum glycoprotein, conserved site
InterPro IPR001124 Lipid-binding serum glycoprotein, C-terminal
InterPro IPR017942 Lipid-binding serum glycoprotein, N-terminal
InterPro IPR030179 Phospholipid transfer protein
Protein Ontology PR:000012888 phospholipid transfer protein
References
(Earliest) J:27216 Jiang XC, et al., Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995 Jul 21;270(29):17133-8
(Latest) J:220558 Manchekar M, et al., Phospholipid Transfer Protein Plays a Major Role in the Initiation of Apolipoprotein B-containing Lipoprotein Assembly in Mouse Primary Hepatocytes. J Biol Chem. 2015 Mar 27;290(13):8196-205
All references(80)
Other
accession IDs
MGD-MRK-24017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory