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Pltp
Gene Detail
 Symbol
Name
ID
Pltp
phospholipid transfer protein
MGI:103151
Synonyms Bpife, OD107
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr2:164839518-164857711 bp, - strand
From VEGA annotation of GRCm38

  18194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phospho/glycolipid-binding protein, BPI/LBP type
Gene Tree: Pltp

Human
homologs
Human Homolog PLTP, phospholipid transfer protein
NCBI Gene ID 5360
neXtProt AC  NX_P55058
Human Synonyms  BPIFE, HDLCQ9
Human Chr (Location)  20q13.12; chr20:45898620-45912364 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLTP
Alleles
and
phenotypes
All alleles(28) : Gene trapped(27) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have lower levels of circulating HDL and exhibit symptoms of dry eye syndrome such as corneal epithelial damage.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process lipid transport, sperm motility, ...
Component extracellular region, extracellular space
Function lipid binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 22
Assay TypeResults
RT-PCR 2
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001168 (Evidence)
Ensembl Gene ModelENSMUSG00000017754 (Evidence)
Entrez Gene18830 (Evidence)
DFCITC1583034, TC1620036, TC1744133
NIA Mouse Gene IndexU023650
Consensus CDS ProjectCCDS17063.1
International Mouse Knockout Project StatusPltp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001168 VEGA Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript OTTMUST00000002266 VEGA | MGI Sequence Detail 2226 Not Applicable 
polypeptide OTTMUSP00000001111 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
InterPro IPR017954 Lipid-binding serum glycoprotein, conserved site
InterPro IPR001124 Lipid-binding serum glycoprotein, C-terminal
InterPro IPR017942 Lipid-binding serum glycoprotein, N-terminal
Protein Ontology PR:000012888 phospholipid transfer protein
References (Earliest) J:27216 Jiang XC, et al., Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995 Jul 21;270(29):17133-8
(Latest) J:209002 Nguyen AT, et al., Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway. Diabetes. 2014 Feb;63(2):471-82
All references(79)
Other
accession IDs
MGD-MRK-24017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory