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Pltp Gene Detail
Summary
  • Symbol
    Pltp
  • Name
    phospholipid transfer protein
  • Synonyms
    Bpife, OD107
  • Feature Type
    protein coding gene
  • IDs
    MGI:103151
    NCBI Gene: 18830
  • Gene Overview
    MyGene.info: PLTP
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164839518-164857708 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103151
protein coding gene Chr2:164839518-164857711 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026880
protein coding gene Chr2:170348501-170367675 (-)
A/J MGP_AJ_G0026847
protein coding gene Chr2:163378248-163397544 (-)
AKR/J MGP_AKRJ_G0026818
protein coding gene Chr2:168253506-168273144 (-)
BALB/cJ MGP_BALBcJ_G0026856
protein coding gene Chr2:163745254-163763629 (-)
C3H/HeJ MGP_C3HHeJ_G0026598
protein coding gene Chr2:168600963-168620129 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027303
protein coding gene Chr2:175281046-175298848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024674
protein coding gene Chr2:156785182-156803284 (-)
CAST/EiJ MGP_CASTEiJ_G0026056
protein coding gene Chr2:169015725-169034014 (-)
CBA/J MGP_CBAJ_G0026575
protein coding gene Chr2:181640779-181662358 (-)
DBA/2J MGP_DBA2J_G0026713
protein coding gene Chr2:162545298-162563198 (-)
FVB/NJ MGP_FVBNJ_G0026679
protein coding gene Chr2:160966058-160984677 (-)
LP/J MGP_LPJ_G0026815
protein coding gene Chr2:170406022-170424008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026698
protein coding gene Chr2:185198158-185216394 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027360
protein coding gene Chr2:168140642-168161436 (-)
PWK/PhJ MGP_PWKPhJ_G0025793
protein coding gene Chr2:162146504-162165421 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025594
protein coding gene Chr2:167040748-167063321 (-)
WSB/EiJ MGP_WSBEiJ_G0026129
protein coding gene Chr2:169020641-169040045 (-)



Homology
more
  • Human Ortholog
    PLTP, phospholipid transfer protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLTP, phospholipid transfer protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPIFE, HDLCQ9
  • Links
    NCBI Gene ID: 5360
    neXtProt AC: NX_P55058
    UniProt: P55058

  • Chr Location
    20q13.12; chr20:45898620-45912364 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pltp mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have lower levels of circulating HDL and exhibit symptoms of dry eye syndrome such as corneal epithelial damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18830 NCBI Gene Model | MGI Sequence Detail 18191 C57BL/6J ±  kb
    transcript NM_011125 RefSeq | MGI Sequence Detail 1806 C57BL/6  
    polypeptide P55065 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012888 phospholipid transfer protein
    • InterPro Domains
      IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
      IPR032942 BPI/LBP/Plunc family
      IPR030675 Lipid binding protein BPI/LBP
      IPR017954 Lipid-binding serum glycoprotein, conserved site
      IPR001124 Lipid-binding serum glycoprotein, C-terminal
      IPR017942 Lipid-binding serum glycoprotein, N-terminal
      IPR030179 Phospholipid transfer protein
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 9
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24017
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 40
    • Earliest
      J:27216 Jiang XC, et al., Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995 Jul 21;270(29):17133-8
    • Latest
      J:240456 Kuwano T, et al., Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res. 2017 Apr;58(4):731-741

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory