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Serpinb6a
Gene Detail
 Symbol
Name
ID
Serpinb6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
MGI:103123
Synonyms 4930482L21Rik, D330015H01Rik, ovalbumin, Spi3
Feature Type protein coding gene
Genetic Map
Chromosome 13
14.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:33917918-34002794 bp, - strand
From VEGA annotation of GRCm38

  84877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20956  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 5 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinb6a

Human
homologs
Human Homolog SERPINB6, serpin peptidase inhibitor, clade B (ovalbumin), member 6
NCBI Gene ID 5269
neXtProt AC  NX_P35237
Human Synonyms  CAP, DFNB91, MSTP057, PI6, PI-6, PTI, SPI3
Human Chr (Location)  6p25; chr6:2948159-2972165 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SERPINB6
Alleles
and
phenotypes
All alleles(9) : Targeted(2) Gene trapped(7)
 
Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process gonad development, negative regulation of endopeptidase activity, ...
Component cytoplasm, extracellular space, ...
Function peptidase inhibitor activity, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (166)    Tissues (48)    Images (40)
Theiler Stages: 17, 19, 20, 21, 23, 28
Assay TypeResults
RNA in situ 134
Northern blot 9
RT-PCR 23
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(4) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000739 (Evidence)
Ensembl Gene ModelENSMUSG00000060147 (Evidence)
Entrez Gene20719 (Evidence)
DFCITC1573040, TC1594448, TC1597979, TC1622434, TC1638198
DoTSDT.101383761, DT.101740853, DT.495167, DT.55129473, DT.91408709, DT.91447896, DT.94345837
NIA Mouse Gene IndexU034671
PDB1M37
Consensus CDS ProjectCCDS26441.1, CCDS49228.1
International Mouse Knockout Project StatusSerpinb6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000739 VEGA Gene Model | MGI Sequence Detail 84877 C57BL/6J ±  kb
transcript OTTMUST00000001391 VEGA | MGI Sequence Detail 1504 Not Applicable 
polypeptide OTTMUSP00000000666 VEGA | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(12) UniProt(14)
Polymorphisms RFLP(1) : SNPs within 2kb(465 from dbSNP Build 137)    SNPs within 2kb including multiple locations(467)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014697 serpin B6
References (Earliest) J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
(Latest) J:197435 Tan J, et al., Absence of SERPINB6A Causes Sensorineural Hearing Loss with Multiple Histopathologies in the Mouse Inner Ear. Am J Pathol. 2013 Jul;183(1):49-59
All references(49)
Other
accession IDs
MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory