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Serpinb6a
Gene Detail
Symbol

Name
ID
Serpinb6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
MGI:103123
Synonyms
4930482L21Rik, D330015H01Rik, ovalbumin, Spi3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:33917918-34002794 bp, - strand
From VEGA annotation of GRCm38

  84877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20956  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

HCOP human homology predictions: SERPINB6
Protein SuperFamily: serpin
Gene Tree: Serpinb6a

Human
homologs
SERPINB6, serpin peptidase inhibitor, clade B (ovalbumin), member 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5269
neXtProt AC: NX_P35237

Human Synonyms: CAP, DFNB91, MSTP057, PI6, PI-6, PTI, SPI3

Human Chr (Location): 6p25; chr6:2948159-2972165 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINB6

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Radiation induced(1) Targeted(2)
Genomic Mutations involving Serpinb6a (1)
Incidental mutations (data from APF )
 
Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.
 
Interactions
Serpinb6a interacts with 35 markers (Mir7-1, Mir7-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to osmotic stress, gonad development, ...
Component cytoplasm, extracellular exosome, ...
Function peptidase inhibitor activity, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (166)    Tissues (48)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 134
Northern blot 9
RT-PCR 23
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(4) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000739 (Evidence)
Ensembl Gene Model ENSMUSG00000060147 (Evidence)
Entrez Gene 20719 (Evidence)
DFCI TC1594448, TC1573040, TC1638198, TC1622434, TC1597979
DoTS DT.55129473, DT.495167, DT.101740853, DT.101383761, DT.91408709, DT.91447896, DT.94345837
NIA Mouse Gene Index U034671
PDB 1M37
Consensus CDS Project CCDS26441.1, CCDS49228.1
International Mouse Phenotyping Consortium Status Serpinb6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000739 VEGA Gene Model | MGI Sequence Detail 84877 C57BL/6J ±  kb
transcript OTTMUST00000001391 VEGA | MGI Sequence Detail 1504 Not Applicable 
polypeptide OTTMUSP00000000666 VEGA | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(16) UniProt(14)
Polymorphisms
RFLP(1) : SNPs within 2kb(465 from dbSNP Build 137)    SNPs within 2kb including multiple locations(467)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014697 serpin B6
References
(Earliest) J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
(Latest) J:197435 Tan J, et al., Absence of SERPINB6A Causes Sensorineural Hearing Loss with Multiple Histopathologies in the Mouse Inner Ear. Am J Pathol. 2013 Jul;183(1):49-59
All references(47)
Other
accession IDs
MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory