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Serpinb6a Gene Detail
Summary
  • Symbol
    Serpinb6a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6a
  • Synonyms
    4930482L21Rik, D330015H01Rik, ovalbumin, Spi3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103123
    NCBI Gene: 20719
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:34101901-34186777 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.00 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2189 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103123
 protein coding gene Chr13:34101901-34186777 (-)
129S1/SvImJ ENSMUSG00200011807
 protein coding gene Chr13:31297704-31315984 (-)
A/J ENSMUSG00195030295
 protein coding gene Chr13:30387309-30405595 (-)
AKR/J ENSMUSG00220029911
 protein coding gene Chr13:30176618-30194904 (-)
BALB/cJ ENSMUSG00180007687
 protein coding gene Chr13:30687434-30705721 (-)
C3H/HeJ ENSMUSG00175012851
 protein coding gene Chr13:30640403-30658690 (-)
C57BL/6NJ ENSMUSG00215008156
 protein coding gene Chr13:30821248-30839530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018414
 protein coding gene Chr13:29396072-29479833 (-)
CAST/EiJ ENSTCUG00005031650
 protein coding gene Chr13:30718158-30810881 (-)
CBA/J ENSMUSG00210011057
 protein coding gene Chr13:30653186-30671472 (-)
DBA/2J ENSMUSG00185030211
 protein coding gene Chr13:31472342-31490628 (-)
FVB/NJ ENSMUSG00205020151
 protein coding gene Chr13:30353658-30371938 (-)
JF1/MsJ ENSUMUG00000024736
 protein coding gene Chr13:31071174-31089478 (-)
LP/J ENSMUSG00230012329
 protein coding gene Chr13:40796779-40815066 (-)
NOD/ShiLtJ ENSMUSG00190010992
 protein coding gene Chr13:30878283-30896562 (-)
NZO/HlLtJ ENSMUSG00225034001
 protein coding gene Chr13:34612460-34630739 (-)
PWK/PhJ ENSLUMG00010027272
 protein coding gene Chr13:29909388-29927696 (-)
SPRET/EiJ ENSMSPG00010022369
 protein coding gene Chr13:29776556-29796100 (-)
WSB/EiJ ENSIUOG00005027817
 protein coding gene Chr13:30044300-30062602 (-)



Homology
more
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Synonyms
    CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
  • Links
    NCBI Gene ID: 5269
    UniProt: P35237

  • Chr Location
    6p25.2; chr6:2948158-2972375 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SERPINB6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Serpinb6a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    26 strains or lines available
Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    81
  • cDNA Data
    22
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20719 NCBI Gene Model | MGI Sequence Detail 84877 C57BL/6J ±  kb
transcript NM_001164118 RefSeq | MGI Sequence Detail 1654 ZRU/MplStud  
polypeptide Q60854 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 4
    cDNA 24
    Primer pair 4
    Other 1
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778
References
more
  • Summaries
    All 59
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:380050 Fei MY, et al., The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood. 2023 Sep 7;142(10):903-917
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory