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Serpinb6a Gene Detail
Summary
  • Symbol
    Serpinb6a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6a
  • Synonyms
    4930482L21Rik, D330015H01Rik, ovalbumin, Spi3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103123
    NCBI Gene: 20719
  • Gene Overview
    MyGene.info: SERPINB6
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:33917918-34002794 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.00 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103123
protein coding gene Chr13:33917918-34002794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020443
protein coding gene Chr13:32021584-32105732 (-)
A/J MGP_AJ_G0020398
protein coding gene Chr13:31079843-31163880 (-)
AKR/J MGP_AKRJ_G0020375
protein coding gene Chr13:31807131-31900561 (-)
BALB/cJ MGP_BALBcJ_G0020393
protein coding gene Chr13:31156437-31240369 (-)
C3H/HeJ MGP_C3HHeJ_G0020192
protein coding gene Chr13:31734224-31830790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020827
protein coding gene Chr13:33073582-33176351 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018414
protein coding gene Chr13:29396072-29479833 (-)
CAST/EiJ MGP_CASTEiJ_G0019708
protein coding gene Chr13:31402245-31488422 (-)
CBA/J MGP_CBAJ_G0020152
protein coding gene Chr13:34518722-34618439 (-)
DBA/2J MGP_DBA2J_G0020274
protein coding gene Chr13:30603497-30695734 (-)
FVB/NJ MGP_FVBNJ_G0020254
protein coding gene Chr13:30180729-30272211 (-)
LP/J MGP_LPJ_G0020350
protein coding gene Chr13:32244228-32334508 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020285
protein coding gene Chr13:34739486-34840216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020870
protein coding gene Chr13:31463818-31561865 (-)
PWK/PhJ MGP_PWKPhJ_G0019463
protein coding gene Chr13:30719734-30811749 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019288
protein coding gene Chr13:30120548-30212828 (-)
WSB/EiJ MGP_WSBEiJ_G0019770
protein coding gene Chr13:31823318-31918201 (-)



Homology
more
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Vertebrate Orthologs
    16
  • Human Ortholog
    SERPINB6, serpin family B member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP, DFNB91, MSTP057, PI6, PI-6, PTI, SPI3
  • Links
    NCBI Gene ID: 5269
    neXtProt AC: NX_P35237
    UniProt: P35237

  • Chr Location
    6p25.2; chr6:2948159-2972165 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SERPINB6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Serpinb6a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20719 NCBI Gene Model | MGI Sequence Detail 84877 C57BL/6J ±  kb
transcript NM_001164118 RefSeq | MGI Sequence Detail 1654 C57BL/6  
polypeptide Q60854 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 4
    cDNA 21
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory