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Serpinb6a Gene Detail
Summary
  • Symbol
    Serpinb6a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6a
  • Synonyms
    4930482L21Rik, D330015H01Rik, ovalbumin, Spi3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103123
    NCBI Gene: 20719
  • Gene Overview
    MyGene.info: SERPINB6
Location & Maps
more
  • Sequence Map
    Chr13:33917918-34002794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.00 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Vertebrate Orthologs
    16
  • Human Ortholog
    SERPINB6, serpin family B member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP, DFNB91, MSTP057, PI6, PI-6, PTI, SPI3
  • Links
    NCBI Gene ID: 5269
    neXtProt AC: NX_P35237

  • Chr Location
    6p25.2; chr6:2948159-2972165 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SERPINB6 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 91; DFNB91   OMIM: 613453
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Serpinb6a
  • Incidental Mutations
    APF
Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000739 VEGA Gene Model | MGI Sequence Detail 84877 C57BL/6J ±  kb
transcript OTTMUST00000001391 VEGA | MGI Sequence Detail 1504 Not Applicable  
polypeptide OTTMUSP00000000666 VEGA | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    458 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 4
    cDNA 20
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
  • Latest
    J:197435 Tan J, et al., Absence of SERPINB6A Causes Sensorineural Hearing Loss with Multiple Histopathologies in the Mouse Inner Ear. Am J Pathol. 2013 Jul;183(1):49-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory