Serpinb6a
Gene Detail

Symbol Name ID

Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a MGI:103123

Synonyms

4930482L21Rik, D330015H01Rik, ovalbumin, Spi3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

14.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr13:33917918-34002794 bp, - strand From VEGA annotation of GRCm38   84877 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20956  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 5 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinb6a

Human homologs

Human Homolog		SERPINB6, serpin peptidase inhibitor, clade B (ovalbumin), member 6
NCBI Gene ID		5269
neXtProt AC		NX_P35237
Human Synonyms		CAP, DFNB91, MSTP057, PI6, PI-6, PTI, SPI3
Human Chr (Location)		6p25; chr6:2948393-2972399 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SERPINB6

Alleles and phenotypes

All alleles(9) : Targeted(2) Gene trapped(7)
 

Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	gonad development, negative regulation of endopeptidase activity, ...
Component	centrosome, cytoplasm, ...
Function	peptidase inhibitor activity, protease binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (166)    Tissues (48)    Images (40)
Theiler Stages: 17, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	134
Northern blot	9
RT-PCR	23

cDNA source data(168)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(178) Genomic(4) cDNA(170) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000739 (Evidence)
Ensembl Gene Model	ENSMUSG00000060147 (Evidence)
Entrez Gene	20719 (Evidence)
UniGene	252210
DFCI	TC1573040, TC1594448, TC1597979, TC1622434, TC1638198
DoTS	DT.101383761, DT.101740853, DT.495167, DT.55129473, DT.91408709, DT.91447896, DT.94345837
NIA Mouse Gene Index	U034671
PDB	1M37
Consensus CDS Project	CCDS26441.1, CCDS49228.1
International Mouse Knockout Project Status	Serpinb6a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000739	VEGA Gene Model | MGI Sequence Detail	84877	C57BL/6J
transcript	OTTMUST00000001391	VEGA | MGI Sequence Detail	1504	Not Applicable
polypeptide	OTTMUSP00000000666	VEGA | MGI Sequence Detail	399	Not Applicable

All sequences(111) RefSeq(8) UniProt(13)

Polymorphisms

RFLP(1) : SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014697	serpin B6

References

(Earliest) J:26852 Sun J, et al., Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem. 1995 Jul 7;270(27):16089-96
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(48)

Other accession IDs

MGD-MRK-23987, MGI:1922249, MGI:2145313, MGI:2442778