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Btn1a1
Gene Detail
 Symbol
Name
ID
Btn1a1
butyrophilin, subfamily 1, member A1
MGI:103118
Synonyms Btn
Feature Type protein coding gene
Genetic Map
Chromosome 13
9.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr13:23456992-23465901 bp, - strand
From VEGA annotation of GRCm38

  8910 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

Protein SuperFamily: butyrophilin
Gene Tree: Btn1a1

Human
homologs
Human Homolog BTN1A1, butyrophilin, subfamily 1, member A1
NCBI Gene ID 696
neXtProt AC  NX_Q13410
Human Synonyms  BT, BTN, BTN1
Human Chr (Location)  6p22.1; chr6:26500349-26510425 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired lactation and abnormal lipid accumulation in the mammary gland.
 
Interactions
Btn1a1 interacts with 225 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of activated T cell proliferation, negative regulation of cellular metabolic process, ...
Component extracellular space, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (17)    Tissues (14)    Images (6)
Theiler Stages: 17, 23
Assay TypeResults
RNA in situ 17
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) Genomic(5) cDNA(54) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000742 (Evidence)
Ensembl Gene ModelENSMUSG00000000706 (Evidence)
Entrez Gene12231 (Evidence)
UniGene1420
DFCITC1582541, TC1591871
DoTSDT.101364435, DT.87038232, DT.87072037, DT.94393065
NIA Mouse Gene IndexU034598
Consensus CDS ProjectCCDS26339.1
International Mouse Knockout Project StatusBtn1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000742 VEGA Gene Model | MGI Sequence Detail 8910 C57BL/6J ±  kb
transcript OTTMUST00000001396 VEGA | MGI Sequence Detail 3423 Not Applicable 
polypeptide OTTMUSP00000000669 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR003879 Butyrophylin-like
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR018355 SPla/RYanodine receptor subgroup
InterPro IPR006574 SPRY-associated
Protein Ontology PR:000004848 butyrophilin subfamily 1 member A1
References (Earliest) J:23895 Amadou C, et al., Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. Genomics. 1995 Mar 1;26(1):9-20
(Latest) J:175843 Lee FY, et al., Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16;21(2):315-27
All references(43)
Other
accession IDs
MGD-MRK-23982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory