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Ca7 Gene Detail
Summary
  • Symbol
    Ca7
  • Name
    carbonic anhydrase 7
  • Synonyms
    Car7
  • Feature Type
    protein coding gene
  • IDs
    MGI:103100
    NCBI Gene: 12354
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105261326-105276979 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103100
 protein coding gene Chr8:105261321-105276979 (+)
129S1/SvImJ ENSMUSG00200014347
 protein coding gene Chr8:99559453-99575273 (+)
A/J ENSMUSG00195003909
 protein coding gene Chr8:99842902-99858724 (+)
AKR/J ENSMUSG00220011231
 protein coding gene Chr8:100010049-100025870 (+)
BALB/cJ ENSMUSG00180003912
 protein coding gene Chr8:99868353-99884175 (+)
C3H/HeJ ENSMUSG00175002748
 protein coding gene Chr8:99925103-99940925 (+)
C57BL/6NJ ENSMUSG00215001175
 protein coding gene Chr8:99539433-99555257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031450
 protein coding gene Chr8:95723430-95732969 (+)
CAST/EiJ ENSTCUG00005021647
 protein coding gene Chr8:99324532-99340301 (+)
CBA/J ENSMUSG00210014884
 protein coding gene Chr8:99853717-99869535 (+)
DBA/2J ENSMUSG00185004831
 protein coding gene Chr8:105961564-105977384 (+)
FVB/NJ ENSMUSG00205011361
 protein coding gene Chr8:98886524-98902344 (+)
JF1/MsJ ENSUMUG00000012708
 protein coding gene Chr8:108294782-108310602 (+)
LP/J ENSMUSG00230005994
 protein coding gene Chr8:109642126-109657944 (+)
NOD/ShiLtJ ENSMUSG00190012392
 protein coding gene Chr8:99991753-100007569 (+)
NZO/HlLtJ ENSMUSG00225017704
 protein coding gene Chr8:112992610-113008428 (+)
PWK/PhJ ENSLUMG00010003943
 protein coding gene Chr8:99807535-99823291 (+)
SPRET/EiJ ENSMSPG00010028854
 protein coding gene Chr8:101926173-101941835 (+)
WSB/EiJ ENSIUOG00005005804
 protein coding gene Chr8:100671662-100687415 (+)



Homology
more
  • Human Ortholog
    CA7, carbonic anhydrase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CA7, carbonic anhydrase 7
  • Synonyms
    CA-VII, CAVII
  • Links
    NCBI Gene ID: 766
    UniProt: P43166

  • Chr Location
    16q22.1; chr16:66844414-66854153 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced and atypical experimental febrile seizures with the absence of electrographic seizures and abnormal GABA-mediated receptor currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    157
  • cDNA Data
    16
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12354 NCBI Gene Model | MGI Sequence Detail 15654 C57BL/6J ±  kb
transcript NM_001301164 RefSeq | MGI Sequence Detail 1943 C57BL/6  
polypeptide Q9ERQ8 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 2
    cDNA 16
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-23964, MGI:2142739, MGI:8353818
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:26540 Ling B, et al., Conservation of the deduced amino acid sequences of human and mouse carbonic anhydrase VII cdnas. Isozyme Bulletin. 1995;28:32
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory