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Car7
Gene Detail
 Symbol
Name
ID
Car7
carbonic anhydrase 7
MGI:103100
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:104534700-104550343 bp, + strand
From VEGA annotation of GRCm38

  15644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car7

Human
homologs
Human Homolog CA7, carbonic anhydrase VII
NCBI Gene ID 766
neXtProt AC  NX_P43166
Human Synonyms  CAVII
Human Chr (Location)  16q22.1; chr16:66844379-66854149 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced and atypical experimental febrile seizures with the absence of electrographic seizures and abnormal GABA-mediated receptor currents.
 
Interactions
Car7 interacts with 144 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process one-carbon metabolic process, positive regulation of cellular pH reduction, ...
Component cytoplasm, cytosol
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (144)    Tissues (144)    Images (3)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 144
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029166 (Evidence)
Ensembl Gene ModelENSMUSG00000031883 (Evidence)
Entrez Gene12354 (Evidence)
UniGene129265
DFCITC1583920, TC1603841
DoTSDT.60103894, DT.97335570, DT.97408812
NIA Mouse Gene IndexU009726
EC4.2.1.1
Consensus CDS ProjectCCDS22581.1
International Mouse Knockout Project StatusCar7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029166 VEGA Gene Model | MGI Sequence Detail 15644 C57BL/6J ±  kb
transcript OTTMUST00000072339 VEGA | MGI Sequence Detail 1538 Not Applicable 
polypeptide OTTMUSP00000037205 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(16) UniProt(3)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018438 Carbonic anhydrase, CA-VII
Protein Ontology PR:000004924 carbonic anhydrase 7
References (Earliest) J:26540 Ling B, et al., Conservation of the deduced amino acid sequences of human and mouse carbonic anhydrase VII cdnas. Isozyme Bulletin. 1995;28:32
(Latest) J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
All references(38)
Other
accession IDs
MGD-MRK-23964, MGI:2142739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory