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Pdpn Gene Detail
Summary
  • Symbol
    Pdpn
  • Name
    podoplanin
  • Synonyms
    Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:103098
    NCBI Gene: 14726
  • Gene Overview
    MyGene.info: PDPN
Location & Maps
more
  • Sequence Map
    Chr4:143267431-143299564 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32134 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 77.29 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PDPN, podoplanin
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PDPN, podoplanin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGGRUS, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A, T1A2, T1A-2, TI1A
  • Links
    NCBI Gene ID: 10630
    neXtProt AC: NX_Q86YL7

  • Chr Location
    1p36.21; chr1:13583757-13617957 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Targeted
    12
  • Genomic Mutations
    2 involving Pdpn
  • Incidental Mutations
Homozygous null neonates die exhibiting respiratory failure. Mice homozygous for another knock-out allele exhibit blood-lymph mixing and intestinal edema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010162 VEGA Gene Model | MGI Sequence Detail 32134 C57BL/6J ±  kb
transcript OTTMUST00000023620 VEGA | MGI Sequence Detail 1817 Not Applicable  
polypeptide OTTMUSP00000010796 VEGA | MGI Sequence Detail 172 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    318 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 27
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23962
References
more
  • Summaries
    All 207
    Developmental Gene Expression 150
    Gene Ontology 14
    Phenotypes 28
  • Earliest
    J:27387 Nose K, et al., Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990 Nov;1(11):511-8
  • Latest
    J:231667 Munger SJ, et al., Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016 Apr 15;412(2):173-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory