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Pdpn
Gene Detail
 Symbol
Name
ID
Pdpn
podoplanin
MGI:103098
Synonyms Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha
Feature Type protein coding gene
Genetic Map
Chromosome 4
77.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:143267431-143299564 bp, - strand
From VEGA annotation of GRCm38

  32134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Pdpn

Human
homologs
Human Homolog PDPN, podoplanin
NCBI Gene ID 10630
neXtProt AC  NX_Q86YL7
Human Synonyms  AGGRUS, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A, T1A2, T1A-2, TI1A
Human Chr (Location)  1p36.21; chr1:13583757-13617957 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(21) Targeted(8)
Incidental mutations (data from Mutagenetix )
 
Homozygous null neonates die exhibiting respiratory failure. Mice homozygous for another knock-out allele exhibit blood-lymph mixing and intestinal edema.
 
Phenotype Images(1)
Interactions
Pdpn interacts with 155 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell adhesion, cell morphogenesis, ...
Component apical plasma membrane, cell projection, ...
External Resources: FuncBase
Expression
Literature Summary: (111 records)
Data Summary: Results (179)    Tissues (63)    Images (66)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 24
RNA in situ 146
Western blot 3
RT-PCR 6
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(27) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010162 (Evidence)
Ensembl Gene ModelENSMUSG00000028583 (Evidence)
Entrez Gene14726 (Evidence)
UniGene2976
DFCITC1581731, TC1590397, TC1646940, TC1678158
DoTSDT.490103, DT.50314932, DT.94281152
NIA Mouse Gene IndexU025752
PDB3IET
Consensus CDS ProjectCCDS38943.1, CCDS71511.1
International Mouse Knockout Project StatusPdpn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010162 VEGA Gene Model | MGI Sequence Detail 32134 C57BL/6J ±  kb
transcript OTTMUST00000023620 VEGA | MGI Sequence Detail 1817 Not Applicable 
polypeptide OTTMUSP00000010796 VEGA | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008783 Podoplanin
Protein Ontology PR:000012516 podoplanin
References (Earliest) J:27387 Nose K, et al., Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990 Nov;1(11):511-8
(Latest) J:206581 Bowles J, et al., Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
All references(166)
Other
accession IDs
MGD-MRK-23962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory