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Pdpn
Gene Detail
Symbol

Name
ID
Pdpn
podoplanin
MGI:103098
Synonyms
Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 4
77.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:143267431-143299564 bp, - strand
From VEGA annotation of GRCm38

  32134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: PDPN
Gene Tree: Pdpn

Human
homologs
PDPN, podoplanin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10630
neXtProt AC: NX_Q86YL7

Human Synonyms: AGGRUS, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A, T1A2, T1A-2, TI1A

Human Chr (Location): 1p36.21; chr1:13583757-13617957 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(21) Targeted(9)
Genomic Mutations involving Pdpn (1)
Incidental mutations (data from Mutagenetix , CvDC )
 
Homozygous null neonates die exhibiting respiratory failure. Mice homozygous for another knock-out allele exhibit blood-lymph mixing and intestinal edema.
 
Phenotype Images(1)
Interactions
Pdpn interacts with 155 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell adhesion, cell morphogenesis, ...
Component apical plasma membrane, cell projection, ...
External Resources: FuncBase
Expression
Literature Summary: (131 records)
Data Summary: Results (184)    Tissues (67)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 146
Western blot 3
RT-PCR 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(27) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010162 (Evidence)
Ensembl Gene Model ENSMUSG00000028583 (Evidence)
Entrez Gene 14726 (Evidence)
UniGene 2976
DFCI TC1590397, TC1581731, TC1646940, TC1678158
DoTS DT.94281152, DT.50314932, DT.490103
NIA Mouse Gene Index U025752
PDB 3IET
Consensus CDS Project CCDS38943.1, CCDS71511.1
International Mouse Phenotyping Consortium Status Pdpn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010162 VEGA Gene Model | MGI Sequence Detail 32134 C57BL/6J ±  kb
transcript OTTMUST00000023620 VEGA | MGI Sequence Detail 1817 Not Applicable 
polypeptide OTTMUSP00000010796 VEGA | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008783 Podoplanin
Protein Ontology PR:000012516 podoplanin
References
(Earliest) J:27387 Nose K, et al., Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990 Nov;1(11):511-8
(Latest) J:217677 Snitow ME, et al., Ezh2 represses the basal cell lineage during lung endoderm development. Development. 2015 Jan 1;142(1):108-17
All references(186)
Other
accession IDs
MGD-MRK-23962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory