About   Help   FAQ
Pdpn Gene Detail
Summary
  • Symbol
    Pdpn
  • Name
    podoplanin
  • Synonyms
    Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:103098
    NCBI Gene: 14726
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:142994001-143026134 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 77.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103098
 protein coding gene Chr4:142993979-143026134 (-)
129S1/SvImJ ENSMUSG00200042304
 protein coding gene Chr4:136403127-136442480 (-)
A/J ENSMUSG00195031841
 protein coding gene Chr4:137776344-137808485 (-)
AKR/J ENSMUSG00220045313
 protein coding gene Chr4:136760541-136792684 (-)
BALB/cJ ENSMUSG00180038950
 protein coding gene Chr4:135416543-135448696 (-)
C3H/HeJ ENSMUSG00175037005
 protein coding gene Chr4:136430878-136463000 (-)
C57BL/6NJ ENSMUSG00215049348
 protein coding gene Chr4:137951876-137984017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026761
 protein coding gene Chr4:132948110-132981158 (-)
CAST/EiJ ENSTCUG00005012608
 protein coding gene Chr4:137393462-137426539 (-)
CBA/J ENSMUSG00210025830
 protein coding gene Chr4:136045723-136077862 (-)
DBA/2J ENSMUSG00185049960
 protein coding gene Chr4:137546876-137579778 (-)
FVB/NJ ENSMUSG00205033607
 protein coding gene Chr4:135819072-135851980 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230038723
 protein coding gene Chr4:141340413-141380103 (-)
NOD/ShiLtJ ENSMUSG00190021389
 protein coding gene Chr4:135810999-135850368 (-)
NZO/HlLtJ ENSMUSG00225007807
 protein coding gene Chr4:147296462-147328596 (-)
PWK/PhJ ENSLUMG00010039561
 protein coding gene Chr4:135242250-135275137 (-)
SPRET/EiJ ENSMSPG00010031626
 protein coding gene Chr4:137281446-137314160 (-)
WSB/EiJ ENSIUOG00005041046
 protein coding gene Chr4:135703057-135742419 (-)



Homology
more
  • Human Ortholog
    PDPN, podoplanin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDPN, podoplanin
  • Synonyms
    AGGRUS, D2-40, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
  • Links
    NCBI Gene ID: 10630
    UniProt: Q86YL7

  • Chr Location
    1p36.21; chr1:13583465-13617957 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 6 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null neonates die exhibiting respiratory failure. Mice homozygous for another knock-out allele exhibit blood-lymph mixing and intestinal edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1117
  • Tissues
    177
  • cDNA Data
    28
  • Literature Summary
    296
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028583 Ensembl Gene Model | MGI Sequence Detail 32134 C57BL/6J ±  kb
    transcript ENSMUST00000030317 Ensembl | MGI Sequence Detail 1817 Not Applicable  
    polypeptide ENSMUSP00000030317 Ensembl | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 28
      Primer pair 15
      Antibodies 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23962
    References
    more
    • Summaries
      All 443
      Developmental Gene Expression 296
      Gene Ontology 19
      Phenotypes 53
    • Earliest
      J:27387 Nose K, et al., Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990 Nov;1(11):511-8
    • Latest
      J:387872 Jafree DJ, et al., Osr1-expressing mesoderm contributes to lymphatic vessel assembly and complexity in the mammalian kidney. Cell Rep. 2026 Jun 19;:117560
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory