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Anapc1 Gene Detail
Summary
  • Symbol
    Anapc1
  • Name
    anaphase promoting complex subunit 1
  • Synonyms
    2610021O03Rik, Apc1, Mcpr, tsg24
  • Feature Type
    protein coding gene
  • IDs
    MGI:103097
    NCBI Gene: 17222
  • Gene Overview
    MyGene.info: ANAPC1
Location & Maps
more
  • Sequence Map
    Chr2:128610104-128687391 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77288 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ANAPC1, anaphase promoting complex subunit 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ANAPC1, anaphase promoting complex subunit 1
    Orthology source: HomoloGene
  • Synonyms
    APC1, MCPR, TSG24
  • Links
    NCBI Gene ID: 64682
    neXtProt AC: NX_Q9H1A4

  • Chr Location
    2q12.1; chr2:111767637-111884186 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Anapc1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015352 VEGA Gene Model | MGI Sequence Detail 77288 C57BL/6J ±  kb
transcript OTTMUST00000036387 VEGA | MGI Sequence Detail 8942 Not Applicable  
polypeptide OTTMUSP00000016356 VEGA | MGI Sequence Detail 1944 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    641 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004012 anaphase-promoting complex subunit 1
  • InterPro Domains
    IPR024990 Anaphase-promoting complex subunit 1
    IPR002015 Proteasome/cyclosome repeat
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-23961, MGI:1923795, MGI:2138834, MGI:2139095, MGI:2139376
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:21751 Starborg M, et al., A novel murine gene encoding a 216-kDa protein is related to a mitotic checkpoint regulator previously identified in Aspergillus nidulans. J Biol Chem. 1994 Sep 30;269(39):24133-7
  • Latest
    J:187715 Xie L, et al., Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14;23(2):280-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory