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Pigr Gene Detail
Summary
  • Symbol
    Pigr
  • Name
    polymeric immunoglobulin receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:103080
    NCBI Gene: 18703
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130826684-130852249 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103080
protein coding gene Chr1:130826684-130852249 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016442
protein coding gene Chr1:134228230-134256793 (+)
A/J MGP_AJ_G0016425
protein coding gene Chr1:129260977-129286505 (+)
AKR/J MGP_AKRJ_G0016390
protein coding gene Chr1:133063883-133091429 (+)
BALB/cJ MGP_BALBcJ_G0016385
protein coding gene Chr1:129593289-129618808 (+)
C3H/HeJ MGP_C3HHeJ_G0016211
protein coding gene Chr1:133207731-133233284 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016846
protein coding gene Chr1:139227017-139252527 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014560
protein coding gene Chr1:122404176-122430542 (+)
CAST/EiJ MGP_CASTEiJ_G0015791
protein coding gene Chr1:132198061-132223634 (+)
CBA/J MGP_CBAJ_G0016183
protein coding gene Chr1:144025905-144051414 (+)
DBA/2J MGP_DBA2J_G0016290
protein coding gene Chr1:128223146-128248681 (+)
FVB/NJ MGP_FVBNJ_G0016289
protein coding gene Chr1:126867641-126893175 (+)
LP/J MGP_LPJ_G0016361
protein coding gene Chr1:135541107-135566627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016314
protein coding gene Chr1:149790796-149816312 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016882
protein coding gene Chr1:132827829-132853346 (+)
PWK/PhJ MGP_PWKPhJ_G0015577
protein coding gene Chr1:127197131-127222757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015364
protein coding gene Chr1:131757900-131785773 (+)
WSB/EiJ MGP_WSBEiJ_G0015853
protein coding gene Chr1:132802214-132827748 (+)



Homology
more
  • Human Ortholog
    PIGR, polymeric immunoglobulin receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIGR, polymeric immunoglobulin receptor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5284
    neXtProt AC: NX_P01833
    UniProt: P01833

  • Chr Location
    1q32.1; chr1:206928522-206946466 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show impaired transepithelial transport of dimeric IgA, increased serum IgA levels and mucosal leakiness. Studies of one null allele show increased susceptibility to mycobacterial infections while another allele causes impaired clearanceof the protozoan parasite Giardia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18703 NCBI Gene Model | MGI Sequence Detail 25566 C57BL/6J ±  kb
transcript NM_011082 RefSeq | MGI Sequence Detail 3849 C57BL/6  
polypeptide O70570 UniProt | EBI | MGI Sequence Detail 771 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 189
    Genomic 18
    cDNA 170
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23944
References
more
  • Summaries
    All 70
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264760 Betz KJ, et al., Enhanced survival following oral and systemic Salmonella enterica serovar Typhimurium infection in polymeric immunoglobulin receptor knockout mice. PLoS One. 2018;13(6):e0198434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory