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Pigr Gene Detail
Summary
  • Symbol
    Pigr
  • Name
    polymeric immunoglobulin receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:103080
    NCBI Gene: 18703
Location & Maps
more
  • Sequence Map
    Chr1:130826684-130852249 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25566 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PIGR, polymeric immunoglobulin receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIGR, polymeric immunoglobulin receptor
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5284
    neXtProt AC: NX_P01833

  • Chr Location
    1q31-q41; chr1:206928522-206946466 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Pigr
  • Incidental Mutations
Nullizygous mice show impaired transepithelial transport of dimeric IgA, increased serum IgA levels and mucosal leakiness. Studies of one null allele show increased susceptibility to mycobacterial infections while another allele causes impaired clearanceof the protozoan parasite Giardia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022632 VEGA Gene Model | MGI Sequence Detail 25566 C57BL/6J ±  kb
transcript OTTMUST00000054216 VEGA | MGI Sequence Detail 3849 Not Applicable  
polypeptide OTTMUSP00000025847 VEGA | MGI Sequence Detail 771 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    276 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 188
    Genomic 18
    cDNA 169
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23944
References
more
  • Summaries
    All 59
    Gene Ontology 4
    Phenotypes 28
  • Earliest
    J:22815 Piskurich JF, et al., Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J Immunol. 1995 Feb 15;154(4):1735-47
  • Latest
    J:222007 Armitage CW, et al., Evaluation of intra- and extra-epithelial secretory IgA in chlamydial infections. Immunology. 2014 Dec;143(4):520-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory