Pigr
Gene Detail

Symbol Name ID

Pigr polymeric immunoglobulin receptor MGI:103080

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.89 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:130826684-130852249 bp, + strand From VEGA annotation of GRCm38   25566 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: polymeric-immunoglobulin receptor
Gene Tree: Pigr

Human homologs

Human Homolog		PIGR, polymeric immunoglobulin receptor
NCBI Gene ID		5284
neXtProt AC		NX_P01833
Human Chr (Location)		1q31-q41; chr1:207101867-207119811 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Nullizygous mice show impaired transepithelial transport of dimeric IgA, increased serum IgA levels and mucosal leakiness. Studies of one null allele show increased susceptibility to mycobacterial infections while another allele causes impaired clearance of the protozoan parasite Giardia.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Component	extracellular region, integral to membrane, ...
Function	epidermal growth factor receptor binding

External Resources: FuncBase

Expression

cDNA source data(163)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(183) Genomic(18) cDNA(164) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022632 (Evidence)
Ensembl Gene Model	ENSMUSG00000026417 (Evidence)
Entrez Gene	18703 (Evidence)
UniGene	276414
DFCI	TC1576673
DoTS	DT.110906909, DT.490210
NIA Mouse Gene Index	U000775
Consensus CDS Project	CCDS15260.1
International Mouse Knockout Project Status	Pigr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022632	VEGA Gene Model | MGI Sequence Detail	25566	C57BL/6J
transcript	OTTMUST00000054216	VEGA | MGI Sequence Detail	3849	Not Applicable
polypeptide	OTTMUSP00000025847	VEGA | MGI Sequence Detail	771	Not Applicable

All sequences(41) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(233 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000012705	polymeric immunoglobulin receptor

References

(Earliest) J:22815 Piskurich JF, et al., Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J Immunol. 1995 Feb 15;154(4):1735-47
(Latest) J:188783 Reikvam DH, et al., Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice. Eur J Immunol. 2012 Nov;42(11):2959-70
All references(57)

Other accession IDs

MGD-MRK-23944