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Pigr
Gene Detail
Symbol

Name
ID
Pigr
polymeric immunoglobulin receptor
MGI:103080
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.89 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:130826684-130852249 bp, + strand
From VEGA annotation of GRCm38

  25566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PIGR
Protein SuperFamily: polymeric-immunoglobulin receptor
Gene Tree: Pigr

Human
homologs
PIGR, polymeric immunoglobulin receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5284
neXtProt AC: NX_P01833

Human Chr (Location): 1q31-q41; chr1:206928522-206946466 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show impaired transepithelial transport of dimeric IgA, increased serum IgA levels and mucosal leakiness. Studies of one null allele show increased susceptibility to mycobacterial infections while another allele causes impaired clearance of the protozoan parasite Giardia.
 
Interactions
Pigr interacts with 194 markers (Mir15a, Mir16-1, Mir19b-1, ...)
Expression
cDNA source data(168)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495453    NEW 
Molecular
reagents
All nucleic(188) Genomic(18) cDNA(169) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022632 (Evidence)
Ensembl Gene Model ENSMUSG00000026417 (Evidence)
Entrez Gene 18703 (Evidence)
UniGene 276414
DFCI TC1576673
DoTS DT.110906909, DT.490210
NIA Mouse Gene Index U000775
PDB 4NOB, 4NOF
Consensus CDS Project CCDS15260.1
International Mouse Phenotyping Consortium Status Pigr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022632 VEGA Gene Model | MGI Sequence Detail 25566 C57BL/6J ±  kb
transcript OTTMUST00000054216 VEGA | MGI Sequence Detail 3849 Not Applicable 
polypeptide OTTMUSP00000025847 VEGA | MGI Sequence Detail 771 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(276 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000012705 polymeric immunoglobulin receptor
References
(Earliest) J:22815 Piskurich JF, et al., Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J Immunol. 1995 Feb 15;154(4):1735-47
(Latest) J:206794 Rogier EW, et al., Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3074-9
All references(61)
Other
accession IDs
MGD-MRK-23944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory