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Pura
Gene Detail
Symbol

Name
ID
Pura
purine rich element binding protein A
MGI:103079
Synonyms
CAGER-1, Pur alpha, Pur-alpha, ssCRE-BP
Feature Type
protein coding gene
Genetic Map
Chromosome 18
19.46 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:36281097-36301521 bp, + strand
From VEGA annotation of GRCm38

  20425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PURA
Gene Tree: Pura

Human
homologs
PURA, purine-rich element binding protein A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5813
neXtProt AC: NX_Q00577

Human Synonyms: MRD31, PUR1, PURALPHA, PUR-ALPHA

Human Chr (Location): 5q31; chr5:140114123-140119416 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PURA

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are overtly normal within the first few weeks of life but later manifest severe neurological defects and die shortly after weaning. Neuroanatomical abnormalities are also observed.
 
Interactions
Pura interacts with 624 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process apoptotic process, cell differentiation, ...
Component cytoplasm, dendrite, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (96)    Tissues (96)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
cDNA source data(7)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase pura ; ZFIN pura    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033186 (Evidence)
Ensembl Gene Model ENSMUSG00000043991 (Evidence)
Entrez Gene 19290 (Evidence)
DFCI TC1583407, TC1663377
DoTS DT.488380, DT.101362975
NIA Mouse Gene Index U018576
Consensus CDS Project CCDS29151.1
International Mouse Phenotyping Consortium Status Pura
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033186 VEGA Gene Model | MGI Sequence Detail 20425 C57BL/6J ±  kb
transcript OTTMUST00000083042 VEGA | MGI Sequence Detail 14943 Not Applicable 
polypeptide OTTMUSP00000044566 VEGA | MGI Sequence Detail 321 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006628 PUR-alpha/beta/gamma, DNA/RNA-binding
Protein Ontology PR:000013494 transcriptional activator protein Pur-alpha
References
(Earliest) J:21627 Ma ZW, et al., Conservation in human and mouse Pur alpha of a motif common to several proteins involved in initiation of DNA replication. Gene. 1994 Nov 18;149(2):311-4
(Latest) J:179606 Hokkanen S, et al., Lack of Pur-alpha alters postnatal brain development and causes megalencephaly. Hum Mol Genet. 2012 Feb 1;21(3):473-84
All references(51)
Other
accession IDs
MGD-MRK-23943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory