Stx3 MGI Mouse Gene Detail - MGI:103077

Symbol

Stx3
Name

syntaxin 3
Synonyms

Syn-3, syntaxin 3A, syntaxin 3B

Feature Type

protein coding gene
IDs

MGI:103077
NCBI Gene: 20908
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:11752482-11796767 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.52 cM
Mapping Data

2 experiments

SNPs within 2kb

391 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103077	protein coding gene	Chr19:11752482-11798933 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024886	protein coding gene	Chr19:9165095-9211548 (-)
A/J	MGP_AJ_G0024860	protein coding gene	Chr19:8652370-8697825 (-)
AKR/J	MGP_AKRJ_G0024835	protein coding gene	Chr19:8976917-9031576 (-)
BALB/cJ	MGP_BALBcJ_G0024860	protein coding gene	Chr19:8653740-8698314 (-)
C3H/HeJ	MGP_C3HHeJ_G0024626	protein coding gene	Chr19:8876808-8925111 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025308	protein coding gene	Chr19:9615491-9666393 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022734	protein coding gene	Chr19:9239140-9282733 (-)
CAST/EiJ	MGP_CASTEiJ_G0024099	protein coding gene	Chr19:8469697-8528198 (-)
CBA/J	MGP_CBAJ_G0024600	protein coding gene	Chr19:9682464-9730947 (-)
DBA/2J	MGP_DBA2J_G0024727	protein coding gene	Chr19:8615440-8661602 (-)
FVB/NJ	MGP_FVBNJ_G0024694	protein coding gene	Chr19:8647280-8690570 (-)
LP/J	MGP_LPJ_G0024814	protein coding gene	Chr19:9167005-9218540 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024721	protein coding gene	Chr19:9593012-9644966 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025356	protein coding gene	Chr19:8961252-9009724 (-)
PWK/PhJ	MGP_PWKPhJ_G0023843	protein coding gene	Chr19:8083074-8126809 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023649	protein coding gene	Chr19:8135542-8187701 (-)
WSB/EiJ	MGP_WSBEiJ_G0024161	protein coding gene	Chr19:8811361-8863149 (-)

Human Ortholog

STX3, syntaxin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX3, syntaxin 3
Synonyms

DIAR12, MVID2, RDMVID, STX3A
Links

HGNC:11438

NCBI Gene ID: 6809

neXtProt AC: NX_Q13277

UniProt: Q13277
Chr Location

11q12.1; chr11:59713456-59805882 (+) GRCh38

MGI Vertebrate Homology

Stx3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STX3
Gene Tree

Stx3

Diseases

1 with human STX3 associations

				Human Disease	Mouse Models
				congenital diarrhea IDs congenital diarrhea DOID:0060774 OMIM:PS214700

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 3 alleles in 4 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

9
Targeted

2
Transposon induced

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

91
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

86
cDNA Data

24
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stx3

ZFIN stx3b

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All Sequences

93
RefSeq

23
UniProt

5
CCDS

CCDS29611.1, CCDS29612.1, CCDS29613.1

Ensembl

ENSMUSG00000041488 (Evidence)
NCBI Gene

20908

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041488	Ensembl Gene Model \| MGI Sequence Detail	44286	C57BL/6J	± kb
transcript	ENSMUST00000069285	Ensembl \| MGI Sequence Detail	2810	Not Applicable
polypeptide	ENSMUSP00000069529	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015795 syntaxin-3

(term hierarchy)
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR031186 Syntaxin-3, SNARE motif

IPR006012 Syntaxin/epimorphin, conserved site

IPR006011 Syntaxin, N-terminal domain

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 34

cDNA 28

Primer pair 6

Microarray probesets 11

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MGD-MRK-23941, MGI:2147464, MGI:2147666, MGI:2147735

Summaries

All 58

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 10
Earliest

J:26509 Ibaraki K, et al., Identification of four different forms of syntaxin 3. Biochem Biophys Res Commun. 1995 Jun 26;211(3):997-1005
Latest

J:322390 Janecke AR, et al., Pathogenic STX3 variants affecting the retinal and intestinal transcripts cause an early-onset severe retinal dystrophy in microvillus inclusion disease subjects. Hum Genet. 2021 Aug;140(8):1143-1156

TSS for Stx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158400	Chr19:11796283-11796329 (-)	461 bp
Tssr158399	Chr19:11796170-11796247 (-)	558 bp
Tssr158398	Chr19:11795782-11795806 (-)	973 bp
Tssr158397	Chr19:11780798-11780816 (-)	15,960 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23