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Zp1 Gene Detail
Summary
  • Symbol
    Zp1
  • Name
    zona pellucida glycoprotein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103073
    NCBI Gene: 22786
Location & Maps
more
  • Sequence Map
    Chr19:10914287-10920632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6346 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 7.36 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ZP1, zona pellucida glycoprotein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ZP1, zona pellucida glycoprotein 1
    Orthology source: HomoloGene
  • Synonyms
    HEL163, OOMD, OOMD1
  • Links
    NCBI Gene ID: 22917
    neXtProt AC: NX_P60852

  • Chr Location
    11q12.2; chr11:60867542-60875693 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ZP1 associations

Human Disease Mouse Models
       Oocyte Maturation Defect 1; OOMD1   OMIM: 615774
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female homozygous mutants produce oocytes with abnormal zona pellucida. Fecunditiy is significantly reduced, probably due to precocious hatching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036734 VEGA Gene Model | MGI Sequence Detail 6346 C57BL/6J ±  kb
transcript OTTMUST00000094201 VEGA | MGI Sequence Detail 1963 Not Applicable  
polypeptide OTTMUSP00000052347 VEGA | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    93 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000018210 zona pellucida sperm-binding protein 1
  • InterPro Domains
    IPR017957 P-type trefoil, conserved site
    IPR000519 P-type trefoil domain
    IPR001507 Zona pellucida domain
    IPR017977 Zona pellucida domain, conserved site
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 14
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23937
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:21969 Harris JD, et al., Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. DNA Seq. 1994;4(6):361-93
  • Latest
    J:215794 Avella MA, et al., A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. J Cell Biol. 2014 Jun 23;205(6):801-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory