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Zyx Gene Detail
Summary
  • Symbol
    Zyx
  • Name
    zyxin
  • Synonyms
    R75157
  • Feature Type
    protein coding gene
  • IDs
    MGI:103072
    NCBI Gene: 22793
  • Gene Overview
    MyGene.info: ZYX
Location & Maps
more
  • Sequence Map
    Chr6:42349630-42360213 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10584 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 20.64 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZYX, zyxin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZYX, zyxin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ESP-2, HED-2
  • Links
    NCBI Gene ID: 7791
    neXtProt AC: NX_Q15942

  • Chr Location
    7q32; chr7:143378329-143391111 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking functional copies of this gene are viable, fertile, and develop normally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057508 VEGA Gene Model | MGI Sequence Detail 10584 C57BL/6J ±  kb
transcript OTTMUST00000141410 VEGA | MGI Sequence Detail 2605 Not Applicable  
polypeptide OTTMUSP00000073915 VEGA | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 154
    Genomic 1
    cDNA 150
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23936, MGI:2141796, MGI:2444302
References
more
  • Summaries
    All 49
    Developmental Gene Expression 16
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:27710 Sadler I, et al., Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol. 1992 Dec;119(6):1573-87
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory