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Ecm1
Gene Detail
Symbol

Name
ID
Ecm1
extracellular matrix protein 1
MGI:103060
Synonyms
p85
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr3:95734147-95739569 bp, - strand
From VEGA annotation of GRCm38

  5423 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: ECM1
Gene Tree: Ecm1

Human
homologs
ECM1, extracellular matrix protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1893
neXtProt AC: NX_Q16610

Human Synonyms: URBWD

Human Chr (Location): 1q21; chr1:150508011-150513789 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ECM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit auto-inflammatory disease and do not survive beyond 6 to 8 weeks of age.
 
Interactions
Ecm1 interacts with 25 markers (Mir25, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, biomineral tissue development, ...
Component extracellular exosome, extracellular matrix, ...
Function enzyme binding, interleukin-2 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (20)    Tissues (10)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
Northern blot 14
RT-PCR 5
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) cDNA(113) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030311 (Evidence)
Ensembl Gene Model ENSMUSG00000028108 (Evidence)
Entrez Gene 13601 (Evidence)
UniGene 3433
DFCI TC1574159
DoTS DT.494671
NIA Mouse Gene Index U024368
Consensus CDS Project CCDS17619.1, CCDS57237.1
International Mouse Phenotyping Consortium Status Ecm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030311 VEGA Gene Model | MGI Sequence Detail 5423 C57BL/6J ±  kb
transcript OTTMUST00000075058 VEGA | MGI Sequence Detail 1900 Not Applicable 
polypeptide OTTMUSP00000039277 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(12) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008605 Extracellular matrix 1
InterPro IPR020858 Serum albumin-like
Protein Ontology PR:000006879 extracellular matrix protein 1
References
(Earliest) J:26941 Capeless CG, et al., Hydrolysis of sucrose octa-acetate: qualitative differences in taster and demistaster avoidance phenotypes. Chem Senses. 1994 Dec;19(6):595-607
(Latest) J:168252 Li Z, et al., ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol. 2011 Feb;12(2):178-85
All references(41)
Other
accession IDs
MGD-MRK-23922, MGI:2139781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory