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Tarbp2 Gene Detail
Summary
  • Symbol
    Tarbp2
  • Name
    TAR (HIV) RNA binding protein 2
  • Synonyms
    Prbp, TRBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:103027
    NCBI Gene: 21357
  • Gene Overview
    MyGene.info: TARBP2
Location & Maps
more
  • Sequence Map
    Chr15:102518192-102523676 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5485 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.65 cM, cytoband F
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TARBP2, TARBP2, RISC loading complex RNA binding subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TARBP2, TARBP2, RISC loading complex RNA binding subunit
    Orthology source: HomoloGene
  • Synonyms
    LOQS, TRBP, TRBP1, TRBP2
  • Links
    NCBI Gene ID: 6895
    neXtProt AC: NX_Q15633

  • Chr Location
    12q13.13; chr12:53500203-53506431 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Tarbp2
  • Incidental Mutations
Homozygous inactivation of this gene results in lethality at weaning, decreased body weight, and male infertility associated with oligozoospermia and failure of spermiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033455 VEGA Gene Model | MGI Sequence Detail 5485 C57BL/6J ±  kb
transcript OTTMUST00000084049 VEGA | MGI Sequence Detail 1523 Not Applicable  
polypeptide OTTMUSP00000045233 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000016056 RISC-loading complex subunit TARBP2
  • InterPro Domains
    IPR014720 Double-stranded RNA-binding domain
    IPR028605 RISC-loading complex subunit TRBP2
Molecular
Reagents
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  • All nucleic 77
    Genomic 1
    cDNA 73
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-23864, MGD-MRK-37240, MGI:108201
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:22835 Kozak CA, et al., Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). Genomics. 1995 Jan 1;25(1):66-72
  • Latest
    J:222613 Ding J, et al., Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul;47(7):776-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory