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Fcgrt Gene Detail
Summary
  • Symbol
    Fcgrt
  • Name
    Fc receptor, IgG, alpha chain transporter
  • Synonyms
    FcRn, neonatal Fc receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:103017
    NCBI Gene: 14132
  • Gene Overview
    MyGene.info: FCGRT
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45092990-45103851 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10862 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.12 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FCGRT, Fc fragment of IgG receptor and transporter
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCGRT, Fc fragment of IgG receptor and transporter
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alpha-chain, FCRN
  • Links
    NCBI Gene ID: 2217
    neXtProt AC: NX_P55899
    UniProt: P55899

  • Chr Location
    19q13.33; chr19:49512279-49526428 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in defective perinatal transport of maternal IgG, increased clearance of IgG, and diminished IgG antibody response after immunization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058708 VEGA Gene Model | MGI Sequence Detail 10862 C57BL/6J ±  kb
    transcript OTTMUST00000144221 VEGA | MGI Sequence Detail 1602 Not Applicable  
    polypeptide OTTMUSP00000075207 VEGA | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      96 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 154
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23854
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 50
    • Earliest
      J:15612 Ahouse JJ, et al., Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol. 1993 Dec 1;151(11):6076-88
    • Latest
      J:257756 Ohsaki A, et al., Maternal IgG immune complexes induce food allergen-specific tolerance in offspring. J Exp Med. 2018 Jan 2;215(1):91-113

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory