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Fcgrt
Gene Detail
Symbol

Name
ID
Fcgrt
Fc receptor, IgG, alpha chain transporter
MGI:103017
Synonyms
FcRn, neonatal Fc receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45092993-45103822 bp, - strand
From NCBI annotation of GRCm38

  10830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: IgG receptor FcRn large subunit p51
Gene Tree: Fcgrt

Human
homologs
Human Homolog FCGRT, Fc fragment of IgG, receptor, transporter, alpha
NCBI Gene ID 2217
neXtProt AC  NX_P55899
Human Synonyms  alpha-chain, FCRN
Human Chr (Location)  19q13.3; chr19:49512279-49526428 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(29) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in defective perinatal transport of maternal IgG, increased clearance of IgG, and diminished IgG antibody response after immunization.
 
Interactions
Fcgrt interacts with 47 markers (Mir15a, Mir26a-2, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process antigen processing and presentation, Fc-gamma receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function antigen binding, beta-2-microglobulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (163)    Tissues (39)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
RT-PCR 9
cDNA source data(154)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(155) cDNA(154) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003420 (Evidence)
Entrez Gene14132 (Evidence)
UniGene3303
DFCITC1572741, TC1590403, TC1629527, TC1719249
DoTSDT.101242550, DT.110999453, DT.55107658, DT.87051213
NIA Mouse Gene IndexU028514
Consensus CDS ProjectCCDS52243.1
International Mouse Knockout Project StatusFcgrt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14132 NCBI Gene Model | MGI Sequence Detail 10830 C57BL/6J ±  kb
transcript NM_010189 RefSeq | MGI Sequence Detail 1738 C57BL/6 
polypeptide Q61559 UniProt | EBI | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000007435 IgG receptor FcRn large subunit p51
Graphical View of Protein Domain Structure
References
(Earliest) J:15612 Ahouse JJ, et al., Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol. 1993 Dec 1;151(11):6076-88
(Latest) J:209206 Baker K, et al., Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity. 2013 Dec 12;39(6):1095-107
All references(87)
Other
accession IDs
MGD-MRK-23854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory