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Fcgrt Gene Detail
Summary
  • Symbol
    Fcgrt
  • Name
    Fc receptor, IgG, alpha chain transporter
  • Synonyms
    FcRn, neonatal Fc receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:103017
    NCBI Gene: 14132
  • Gene Overview
    MyGene.info: FCGRT
Location & Maps
more
  • Sequence Map
    Chr7:45092993-45103822 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10830 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.12 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FCGRT, Fc fragment of IgG receptor and transporter
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCGRT, Fc fragment of IgG receptor and transporter
    Orthology source: HGNC, HomoloGene
  • Synonyms
    alpha-chain, FCRN
  • Links
    NCBI Gene ID: 2217
    neXtProt AC: NX_P55899

  • Chr Location
    19q13.3; chr19:49512279-49526428 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Gene trapped
    29
  • Targeted
    5
  • Transgenic
    3
  • Incidental Mutations
Homozygous mutation of this gene results in defective perinatal transport of maternal IgG, increased clearance of IgG, and diminished IgG antibody response after immunization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003420 Ensembl Gene Model | MGI Sequence Detail 10830 C57BL/6J ±  kb
transcript ENSMUST00000003512 Ensembl | MGI Sequence Detail 1738 Not Applicable  
polypeptide ENSMUSP00000003512 Ensembl | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    96 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007435 IgG receptor FcRn large subunit p51
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR027648 MHC class I alpha chain
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
Molecular
Reagents
less
  • All nucleic 155
    cDNA 154
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23854
References
more
  • Summaries
    All 85
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 46
  • Earliest
    J:15612 Ahouse JJ, et al., Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol. 1993 Dec 1;151(11):6076-88
  • Latest
    J:220803 Roopenian DC, et al., Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs. MAbs. 2015;7(2):344-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory