Ppp1ca
Gene Detail

Symbol Name ID

Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform MGI:103016

Synonyms

dism2, Ppp1c

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.89 cM, cytoband E3-F2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:4192174-4195419 bp, + strand From NCBI annotation of GRCm38   3246 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:105262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp1ca

Human homologs

Human Homolog		PPP1CA, protein phosphatase 1, catalytic subunit, alpha isozyme
NCBI Gene ID		5499
neXtProt AC		NX_P62136
Human Synonyms		PP1A, PP-1A, PP1alpha, PPP1A
Human Chr (Location)		11q13; chr11:67165652-67169376 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(2) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	branching morphogenesis of an epithelial tube, carbohydrate metabolic process, ...
Component	cytoplasm, dendritic spine, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (78)    Tissues (46)    Images (25)
Theiler Stages: 16, 18, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	47
Western blot	14
RT-PCR	17

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(21) Primer pair(3) Other(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000040385 (Evidence)
Entrez Gene	19045 (Evidence)
DFCI	TC1573757
EC	3.1.3.16
Consensus CDS Project	CCDS29421.1
International Mouse Knockout Project Status	Ppp1ca

Sequences

Length	Strain/Species
genomic	19045	NCBI Gene Model | MGI Sequence Detail	3246	C57BL/6J
transcript	NM_031868	RefSeq | MGI Sequence Detail	1363	C57BL/6
polypeptide	P62137	UniProt | EBI | MGI Sequence Detail	330	Not Applicable

All sequences(44) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000003209	serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Graphical View of Protein Domain Structure

References

(Earliest) J:22480 Saadat M, et al., Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet. 1994 Dec;69(6):697-700
(Latest) J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7
All references(48)

Other accession IDs

MGD-MRK-23853