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Ppp1ca Gene Detail
Summary
  • Symbol
    Ppp1ca
  • Name
    protein phosphatase 1 catalytic subunit alpha
  • Synonyms
    dism2, Ppp1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:103016
    NCBI Gene: 19045
  • Gene Overview
    MyGene.info: PPP1CA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4192174-4195419 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.89 cM, cytoband E3-F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103016
protein coding gene Chr19:4192158-4195419 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024655
protein coding gene Chr19:1034783-1039645 (+)
A/J MGP_AJ_G0024621
protein coding gene Chr19:993943-997207 (+)
AKR/J MGP_AKRJ_G0024594
protein coding gene Chr19:1018665-1021924 (+)
BALB/cJ MGP_BALBcJ_G0024621
protein coding gene Chr19:984690-987955 (+)
C3H/HeJ MGP_C3HHeJ_G0024389
protein coding gene Chr19:1015049-1019352 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025069
protein coding gene Chr19:1070990-1074256 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022498
protein coding gene Chr19:937413-940665 (+)
CAST/EiJ MGP_CASTEiJ_G0023861
protein coding gene Chr19:1030692-1033970 (+)
CBA/J MGP_CBAJ_G0024360
protein coding gene Chr19:1133352-1136612 (+)
DBA/2J MGP_DBA2J_G0024488
protein coding gene Chr19:954682-957943 (+)
FVB/NJ MGP_FVBNJ_G0024455
protein coding gene Chr19:963881-967142 (+)
LP/J MGP_LPJ_G0024574
protein coding gene Chr19:1028396-1031658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024485
protein coding gene Chr19:1076613-1079876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025116
protein coding gene Chr19:1019385-1022646 (+)
PWK/PhJ MGP_PWKPhJ_G0023607
protein coding gene Chr19:1007824-1011181 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023412
protein coding gene Chr19:1001039-1004306 (+)
WSB/EiJ MGP_WSBEiJ_G0023923
protein coding gene Chr19:1005277-1010223 (+)



Homology
more
  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP1A, PP-1A, PP1alpha, PPP1A
  • Links
    NCBI Gene ID: 5499
    neXtProt AC: NX_P62136
    UniProt: P62136

  • Chr Location
    11q13.2; chr11:67398181-67401905 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19045 NCBI Gene Model | MGI Sequence Detail 3246 C57BL/6J ±  kb
transcript NM_031868 RefSeq | MGI Sequence Detail 1363 C57BL/6  
polypeptide P62137 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003209 serine/threonine-protein phosphatase PP1-alpha catalytic subunit
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR037979 Serine/threonine-protein phosphatase PP1 catalytic subunit alpha/beta
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
less
  • All nucleic 27
    cDNA 22
    Primer pair 3
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-23853
References
more
  • Summaries
    All 65
    Developmental Gene Expression 6
    Gene Ontology 23
    Phenotypes 5
  • Earliest
    J:22480 Saadat M, et al., Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet. 1994 Dec;69(6):697-700
  • Latest
    J:255286 Nagarajan S, et al., Protein Phosphatase 1alpha enhances renal aldosterone signaling via mineralocorticoid receptor stabilization. Mol Cell Endocrinol. 2017 Jul 15;450:74-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory