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Ppp1ca
Gene Detail
Symbol

Name
ID
Ppp1ca
protein phosphatase 1, catalytic subunit, alpha isoform
MGI:103016
Synonyms
dism2, Ppp1c
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.89 cM, cytoband E3-F2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:4192174-4195419 bp, + strand
From NCBI annotation of GRCm38

  3246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp1ca

Human
homologs
Human Homolog PPP1CA, protein phosphatase 1, catalytic subunit, alpha isozyme
NCBI Gene ID 5499
neXtProt AC  NX_P62136
Human Synonyms  PP1A, PP-1A, PP1alpha, PPP1A
Human Chr (Location)  11q13; chr11:67398181-67401905 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(20) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ppp1ca interacts with 103 markers (Mir17, Mir20b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process branching morphogenesis of an epithelial tube, carbohydrate metabolic process, ...
Component cytoplasm, dendritic spine, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (78)    Tissues (47)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 47
Western blot 14
RT-PCR 17
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(21) Primer pair(3) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000040385 (Evidence)
Entrez Gene19045 (Evidence)
DFCITC1573757
EC3.1.3.16
Consensus CDS ProjectCCDS29421.1
International Mouse Knockout Project StatusPpp1ca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19045 NCBI Gene Model | MGI Sequence Detail 3246 C57BL/6J ±  kb
transcript NM_031868 RefSeq | MGI Sequence Detail 1363 C57BL/6 
polypeptide P62137 UniProt | EBI | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000003209 serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:22480 Saadat M, et al., Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet. 1994 Dec;69(6):697-700
(Latest) J:203862 Lobbestael E, et al., Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J. 2013 Nov 15;456(1):119-28
All references(55)
Other
accession IDs
MGD-MRK-23853

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory