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Ppp1ca Gene Detail
Summary
  • Symbol
    Ppp1ca
  • Name
    protein phosphatase 1, catalytic subunit, alpha isoform
  • Synonyms
    dism2, Ppp1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:103016
    NCBI Gene: 19045
  • Gene Overview
    MyGene.info: PPP1CA
Location & Maps
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Homology
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  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PP1A, PP-1A, PP1alpha, PPP1A
  • Links
    NCBI Gene ID: 5499
    neXtProt AC: NX_P62136

  • Chr Location
    11q13; chr11:67398181-67401905 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19045 NCBI Gene Model | MGI Sequence Detail 3246 C57BL/6J ±  kb
transcript NM_031868 RefSeq | MGI Sequence Detail 1363 C57BL/6  
polypeptide P62137 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003209 serine/threonine-protein phosphatase PP1-alpha catalytic subunit
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 26
    cDNA 21
    Primer pair 3
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-23853
References
more
  • Summaries
    All 55
    Developmental Gene Expression 5
    Gene Ontology 22
    Phenotypes 5
  • Earliest
    J:22480 Saadat M, et al., Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet. 1994 Dec;69(6):697-700
  • Latest
    J:213891 Nawa M, et al., KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013;14:27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory