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Epb4.1l3
Gene Detail
Symbol

Name
ID
Epb4.1l3
erythrocyte protein band 4.1-like 3
MGI:103008
Synonyms
4.1B, DAL1P, NBL3
Feature Type
protein coding gene
Genetic Map
Chromosome 17
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:69156810-69289985 bp, + strand
From Ensembl annotation of GRCm38

  133176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane skeletal protein 4.1
Gene Tree: Epb4.1l3

Human
homologs
Human Homolog EPB41L3, erythrocyte membrane protein band 4.1-like 3
NCBI Gene ID 23136
neXtProt AC  NX_Q9Y2J2
Human Synonyms  4.1B, DAL1, DAL-1
Human Chr (Location)  18p11.32; chr18:5392381-5630663 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele display a normal phenotype. Mice homozygous for a different knock-out allele exhibit ataxia, gait abnormalities, clasping, hypermyelination, abnormal axon morphology, and decreased internode length.
 
Phenotype Images(4)
Interactions
Epb4.1l3 interacts with 238 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process apoptotic process, cortical actin cytoskeleton organization, ...
Component axolemma, cell, ...
Function actin binding, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (45)    Tissues (31)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(61) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000024044 (Evidence)
Entrez Gene13823 (Evidence)
UniGene131135
DFCITC1617143, TC1591442, TC1587475, TC1580354
DoTSDT.101265720, DT.103587759, DT.103587381, DT.101737314, DT.522882, DT.99640104, DT.94172210
Consensus CDS ProjectCCDS28952.1
International Mouse Knockout Project StatusEpb4.1l3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024044 Ensembl Gene Model | MGI Sequence Detail 133176 C57BL/6J ±  kb
transcript ENSMUST00000112680 Ensembl | MGI Sequence Detail 4073 Not Applicable 
polypeptide ENSMUSP00000108300 Ensembl | MGI Sequence Detail 939 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(68) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(975 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008379 Band 4.1, C-terminal
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR021187 Band 4.1 protein
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR007477 SAB domain
Protein Ontology PR:000007110 band 4.1-like protein 3
References
(Earliest) J:19489 Takeuchi K, et al., Structural diversity of band 4.1 superfamily members. J Cell Sci. 1994 Jul;107(Pt 7):1921-8
(Latest) J:213024 Wang J, et al., A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization. J Biol Chem. 2014 Feb 28;289(9):5925-37
All references(54)
Other
accession IDs
MGD-MRK-23845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory