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Epb41l3 Gene Detail
Summary
  • Symbol
    Epb41l3
  • Name
    erythrocyte membrane protein band 4.1 like 3
  • Synonyms
    4.1B, DAL1P, Epb4.1l3, NBL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103008
    NCBI Gene: 13823
Location & Maps
more
  • Sequence Map
    Chr17:69156810-69289985 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      133176 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EPB41L3, erythrocyte membrane protein band 4.1-like 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPB41L3, erythrocyte membrane protein band 4.1-like 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    4.1B, DAL1, DAL-1
  • Links
    NCBI Gene ID: 23136
    neXtProt AC: NX_Q9Y2J2

  • Chr Location
    18p11.32; chr18:5392381-5630666 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 4 genetic backgrounds
    4 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele display a normal phenotype. Mice homozygous for a different knock-out allele exhibit ataxia, gait abnormalities, clasping, hypermyelination, abnormal axon morphology, and decreased internode length.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024044 Ensembl Gene Model | MGI Sequence Detail 133176 C57BL/6J ±  kb
transcript ENSMUST00000112680 Ensembl | MGI Sequence Detail 4073 Not Applicable  
polypeptide ENSMUSP00000108300 Ensembl | MGI Sequence Detail 939 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    975 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 62
    cDNA 61
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-23845
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:19489 Takeuchi K, et al., Structural diversity of band 4.1 superfamily members. J Cell Sci. 1994 Jul;107(Pt 7):1921-8
  • Latest
    J:213024 Wang J, et al., A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization. J Biol Chem. 2014 Feb 28;289(9):5925-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory