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Ptgdr
Gene Detail
 Symbol
Name
ID
Ptgdr
prostaglandin D receptor
MGI:102966
Synonyms DP
Feature Type protein coding gene
Genetic Map
Chromosome 14
22.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:44851235-44859375 bp, - strand
From VEGA annotation of GRCm38

  8141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:736  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptgdr

Human
homologs
Human Homolog PTGDR, prostaglandin D2 receptor (DP)
NCBI Gene ID 5729
neXtProt AC  NX_Q13258
Human Synonyms  AS1, ASRT1, DP, DP1, PTGDR1
Human Chr (Location)  14q22.1; chr14:52267592-52277090 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTGDR
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a reduced inflammatory response to airborn allergens and reduced susceptibility to passive cutaneous anaphylaxis induced by IgE antigen challenge due to impaired mast cell degranulation.
 
Interactions
Ptgdr interacts with 249 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adenosine metabolic process, cellular response to prostaglandin D stimulus, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, prostaglandin D receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (65)    Tissues (49)    Images (12)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 19
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036408 (Evidence)
Ensembl Gene ModelENSMUSG00000071489 (Evidence)
Entrez Gene19214 (Evidence)
UniGene5105
DFCITC1591830
DoTSDT.55168546
NIA Mouse Gene IndexU035441
Consensus CDS ProjectCCDS26971.1
International Mouse Knockout Project StatusPtgdr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036408 VEGA Gene Model | MGI Sequence Detail 8141 C57BL/6J ±  kb
transcript OTTMUST00000093306 VEGA | MGI Sequence Detail 3187 Not Applicable 
polypeptide OTTMUSP00000051733 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(3) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(80 from dbSNP Build 137)    SNPs within 2kb including multiple locations(90)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000376 Prostaglandin D receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001656 prostaglandin D2 receptor
References (Earliest) J:21538 Hirata M, et al., Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11192-6
(Latest) J:208268 Kaneko K, et al., delta-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72
All references(59)
Other
accession IDs
MGD-MRK-23803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory