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Ptgdr Gene Detail
Summary
  • Symbol
    Ptgdr
  • Name
    prostaglandin D receptor
  • Synonyms
    DP
  • Feature Type
    protein coding gene
  • IDs
    MGI:102966
    NCBI Gene: 19214
Location & Maps
more
  • Sequence Map
    Chr14:44851235-44859375 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8141 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PTGDR, prostaglandin D2 receptor (DP)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTGDR, prostaglandin D2 receptor (DP)
    Orthology source: HomoloGene
  • Synonyms
    AS1, ASRT1, DP, DP1, PTGDR1
  • Links
    NCBI Gene ID: 5729
    neXtProt AC: NX_Q13258

  • Chr Location
    14q22.1; chr14:52267256-52276724 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PTGDR associations

Human Disease Mouse Models
       Asthma-Related Traits, Susceptibility to, 1   OMIM: 607277
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ptgdr
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a reduced inflammatory response to airborn allergens and reduced susceptibility to passive cutaneous anaphylaxis induced by IgE antigen challenge due to impaired mast cell degranulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036408 VEGA Gene Model | MGI Sequence Detail 8141 C57BL/6J ±  kb
transcript OTTMUST00000093306 VEGA | MGI Sequence Detail 3187 Not Applicable  
polypeptide OTTMUSP00000051733 VEGA | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001656 prostaglandin D2 receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000376 Prostaglandin D receptor
    IPR008365 Prostanoid receptor
Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23803
References
more
  • Summaries
    All 61
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:21538 Hirata M, et al., Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11192-6
  • Latest
    J:222924 Ma X, et al., Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. Cancer Res. 2015 Jul 15;75(14):2822-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory