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Scn7a
Gene Detail
Symbol

Name
ID
Scn7a
sodium channel, voltage-gated, type VII, alpha
MGI:102965
Synonyms
1110034K09Rik, NaG, Nav2, Nav2.3, Nax, Scn6a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
39.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:66673425-66784914 bp, - strand
From VEGA annotation of GRCm38

  111490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn7a

Human
homologs
Human Homolog SCN7A, sodium channel, voltage-gated, type VII, alpha subunit
NCBI Gene ID 6332
neXtProt AC  NX_Q01118
Human Synonyms  NaG, Nav2.1, Nav2.2, SCN6A
Human Chr (Location)  2q21-q23; chr2:166403468-166494232 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.
 
Interactions
Scn7a interacts with 337 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process membrane depolarization during action potential, neuronal action potential, ...
Component glial cell projection, plasma membrane
Function protein binding, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000013100 (Evidence)
Ensembl Gene ModelENSMUSG00000034810 (Evidence)
Entrez Gene20272 (Evidence)
UniGene38127
DFCITC1596958, TC1665571, TC1599764, TC1673654
DoTSDT.483548, DT.110662425, DT.97360766, DT.55164073, DT.94243966, DT.91572400
NIA Mouse Gene IndexU022700
Consensus CDS ProjectCCDS16081.1
International Mouse Knockout Project StatusScn7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013100 VEGA Gene Model | MGI Sequence Detail 111490 C57BL/6J ±  kb
transcript OTTMUST00000031614 VEGA | MGI Sequence Detail 7338 Not Applicable 
polypeptide OTTMUSP00000014084 VEGA | MGI Sequence Detail 1681 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(555 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR010526 Sodium ion transport-associated
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
Protein Ontology PR:000002102 sodium channel protein type 7 subunit alpha
References
(Earliest) J:15695 Potts JF, et al., A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2. Biochem Biophys Res Commun. 1993 Nov 30;197(1):100-4
(Latest) J:190309 Matsumoto M, et al., SAP97 promotes the stability of Nax channels at the plasma membrane. FEBS Lett. 2012 Nov 2;586(21):3805-12
All references(46)
Other
accession IDs
MGD-MRK-14325, MGD-MRK-23802, MGI:1915995, MGI:2139022, MGI:98252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory