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Scn7a Gene Detail
Summary
  • Symbol
    Scn7a
  • Name
    sodium channel, voltage-gated, type VII, alpha
  • Synonyms
    1110034K09Rik, NaG, Nav2, Nav2.3, Nax, Scn6a
  • Feature Type
    protein coding gene
  • IDs
    MGI:102965
    NCBI Gene: 20272
  • Gene Overview
    MyGene.info: SCN7A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:66673426-66784910 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.21 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102965
protein coding gene Chr2:66673425-66784914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025786
protein coding gene Chr2:66536344-66640939 (-)
A/J MGP_AJ_G0025762
protein coding gene Chr2:63941238-64045626 (-)
AKR/J MGP_AKRJ_G0025732
protein coding gene Chr2:65700987-65803809 (-)
BALB/cJ MGP_BALBcJ_G0025757
protein coding gene Chr2:64138278-64246392 (-)
C3H/HeJ MGP_C3HHeJ_G0025518
protein coding gene Chr2:65870364-65983133 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026204
protein coding gene Chr2:68508826-68618762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023608
protein coding gene Chr2:61289995-61386403 (-)
CAST/EiJ MGP_CASTEiJ_G0024982
protein coding gene Chr2:65966664-66077092 (-)
CBA/J MGP_CBAJ_G0025498
protein coding gene Chr2:71068339-71180798 (-)
DBA/2J MGP_DBA2J_G0025629
protein coding gene Chr2:63596453-63703616 (-)
FVB/NJ MGP_FVBNJ_G0025591
protein coding gene Chr2:63016427-63121402 (-)
LP/J MGP_LPJ_G0025717
protein coding gene Chr2:66363397-66479773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025622
protein coding gene Chr2:73047769-73156135 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026261
protein coding gene Chr2:65764822-65867613 (-)
PWK/PhJ MGP_PWKPhJ_G0024723
protein coding gene Chr2:63416355-63516398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024530
protein coding gene Chr2:65933956-66054045 (-)
WSB/EiJ MGP_WSBEiJ_G0025050
protein coding gene Chr2:66147762-66261821 (-)



Homology
more
  • Human Ortholog
    SCN7A, sodium voltage-gated channel alpha subunit 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SCN7A, sodium voltage-gated channel alpha subunit 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NaG, Nav2.1, Nav2.2, SCN6A
  • Links
    NCBI Gene ID: 6332
    neXtProt AC: NX_Q01118
    UniProt: Q01118

  • Chr Location
    2q24.3; chr2:166403573-166494264 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20272 NCBI Gene Model | MGI Sequence Detail 111485 C57BL/6J ±  kb
    transcript NM_009135 RefSeq | MGI Sequence Detail 7333 C57BL/6  
    polypeptide NP_033161 RefSeq | MGI Sequence Detail 1681 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR010526 Sodium ion transport-associated
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028812 Voltage gated sodium channel, alpha-7 subunit
      IPR001696 Voltage gated sodium channel, alpha subunit
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14325, MGD-MRK-23802, MGI:1915995, MGI:2139022, MGI:98252
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:15695 Potts JF, et al., A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2. Biochem Biophys Res Commun. 1993 Nov 30;197(1):100-4
    • Latest
      J:239833 Matsuda T, et al., Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ. Nat Neurosci. 2017 Feb;20(2):230-241

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory