Scn7a
Gene Detail

Symbol Name ID

Scn7a sodium channel, voltage-gated, type VII, alpha MGI:102965

Synonyms

1110034K09Rik, NaG, Nav2, Nav2.3, Nax, Scn6a

Feature Type

protein coding gene

Genetic Map

Chromosome 2

39.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:66673425-66784914 bp, - strand From VEGA annotation of GRCm38   111490 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn7a

Human homologs

Human Homolog		SCN7A, sodium channel, voltage-gated, type VII, alpha subunit
NCBI Gene ID		6332
neXtProt AC		NX_Q01118
Human Synonyms		NaG, Nav2.1, Nav2.2, SCN6A
Human Chr (Location)		2q21-q23; chr2:167260083-167343481 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	ion transport, regulation of ion transmembrane transport, ...
Component	integral to membrane
Function	ion channel activity, sodium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (4)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	6

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000013100 (Evidence)
Ensembl Gene Model	ENSMUSG00000034810 (Evidence)
Entrez Gene	20272 (Evidence)
UniGene	38127
DFCI	TC1596958, TC1599764, TC1665571, TC1673654
DoTS	DT.110662425, DT.483548, DT.55164073, DT.91572400, DT.94243966, DT.97360766
NIA Mouse Gene Index	U022700
Consensus CDS Project	CCDS16081.1
International Mouse Knockout Project Status	Scn7a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013100	VEGA Gene Model | MGI Sequence Detail	111490	C57BL/6J
transcript	OTTMUST00000031614	VEGA | MGI Sequence Detail	7338	Not Applicable
polypeptide	OTTMUSP00000014084	VEGA | MGI Sequence Detail	1681	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(305 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR010526	Sodium ion transport-associated
InterPro	IPR001696	Voltage gated sodium channel, alpha subunit
Protein Ontology	PR:000002102	sodium channel type 7 subunit alpha

References

(Earliest) J:15695 Potts JF, et al., A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2. Biochem Biophys Res Commun. 1993 Nov 30;197(1):100-4
(Latest) J:190309 Matsumoto M, et al., SAP97 promotes the stability of Nax channels at the plasma membrane. FEBS Lett. 2012 Nov 2;586(21):3805-12
All references(46)

Other accession IDs

MGD-MRK-14325, MGD-MRK-23802, MGI:1915995, MGI:2139022, MGI:98252