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Ube2a
Gene Detail
 Symbol
Name
ID
Ube2a
ubiquitin-conjugating enzyme E2A
MGI:102959
Synonyms HHR6A, HR6A
Feature Type protein coding gene
Genetic Map
Chromosome X
21.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:36874358-36884215 bp, + strand
From VEGA annotation of GRCm38

  9858 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2a

Human
homologs
Human Homolog UBE2A, ubiquitin-conjugating enzyme E2A
NCBI Gene ID 7319
neXtProt AC  NX_P49459
Human Synonyms  HHR6A, MRXS30, MRXSN, RAD6A, UBC2
Human Chr (Location)  Xq24; chrX:119574467-119584429 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human UBE2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
 
Homozygous mutation of this gene results in decreased body weight. Females are infertile while males show partial prenatal lethality.
 
Interactions
Ube2a interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component chromatin, HULC complex, ...
Function acid-amino acid ligase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (2)    Images (6)
Theiler Stages: 23
Assay TypeResults
RNA in situ 12
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) cDNA(87) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017105 (Evidence)
Ensembl Gene ModelENSMUSG00000016308 (Evidence)
Entrez Gene22209 (Evidence)
UniGene395649
DFCITC1575060, TC1595945
DoTSDT.534506, DT.99857699, DT.99857700
NIA Mouse Gene IndexU019784
EC6.3.2.19
Consensus CDS ProjectCCDS30064.1
International Mouse Knockout Project StatusUbe2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017105 VEGA Gene Model | MGI Sequence Detail 9858 C57BL/6J ±  kb
transcript OTTMUST00000041426 VEGA | MGI Sequence Detail 1662 Not Applicable 
polypeptide OTTMUSP00000018586 VEGA | MGI Sequence Detail 152 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023313 Ubiquitin-conjugating enzyme, active site
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Protein Ontology PR:000016965 ubiquitin-conjugating enzyme E2 A
References (Earliest) J:12580 Koken MH, et al., Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Genomics. 1992 Mar;12(3):447-53
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)
Other
accession IDs
MGD-MRK-23795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory