Cdk7
Gene Detail

Symbol Name ID

Cdk7 cyclin-dependent kinase 7 MGI:102956

Synonyms

Cdkn7, Crk4, CRK4 PK (CDC2-related-kinase-4 protein kinase)

Feature Type

protein coding gene

Genetic Map

Chromosome 13

53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:100697027-100730942 bp, - strand From Ensembl annotation of GRCm38   33916 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk7

Human homologs

Human Homolog		CDK7, cyclin-dependent kinase 7
NCBI Gene ID		1022
neXtProt AC		NX_P50613
Human Synonyms		CAK1, CDKN7, HCAK, MO15, p39MO15, STK1
Human Chr (Location)		5q12.1; chr5:68530622-68573257 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(280) : Targeted(3) Gene trapped(277)

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	cell cycle, cell division, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 15

Assay Type	Results
RNA in situ	1

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(103) Genomic(3) cDNA(100)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000069089 (Evidence)
Entrez Gene	12572 (Evidence)
UniGene	259718
DoTS	DT.101734497, DT.492514
EC	2.7.11.22, 2.7.11.23
Consensus CDS Project	CCDS36766.1
International Mouse Knockout Project Status	Cdk7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000069089	Ensembl Gene Model | MGI Sequence Detail	33916	C57BL/6J
transcript	ENSMUST00000091299	Ensembl | MGI Sequence Detail	7595	Not Applicable
polypeptide	ENSMUSP00000088845	Ensembl | MGI Sequence Detail	346	Not Applicable

All sequences(32) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005265	cell division protein kinase 7

References

(Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:183925 Ganuza M, et al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012 Apr 13;
All references(48)

Other accession IDs

MGD-MRK-19684, MGD-MRK-2148, MGD-MRK-23792, MGI:2145207, MGI:2145266, MGI:88505