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Cdk7
Gene Detail
 Symbol
Name
ID
Cdk7
cyclin-dependent kinase 7
MGI:102956
Synonyms Cdkn7, Crk4, CRK4 PK (CDC2-related-kinase-4 protein kinase)
Feature Type protein coding gene
Genetic Map
Chromosome 13
53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:100697027-100730942 bp, - strand
From Ensembl annotation of GRCm38

  33916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk7

Human
homologs
Human Homolog CDK7, cyclin-dependent kinase 7
NCBI Gene ID 1022
neXtProt AC  NX_P50613
Human Synonyms  CAK1, CDKN7, HCAK, MO15, p39MO15, STK1
Human Chr (Location)  5q12.1; chr5:69234795-69277430 (+)  GRCh38
Alleles
and
phenotypes
All alleles(280) : Targeted(3) Gene trapped(277)
 
Mice homozygous for null allele exhibit abnormal trophoblast layer morphology, abnormal inner cell mass apoptosis, and complete embryonic lethality during peri-implantation stages. Homoyzgous null MEFs display absent fibroblast proliferation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process ATP catabolic process, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 15
Assay TypeResults
RNA in situ 1
cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(102) Genomic(3) cDNA(99)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000069089 (Evidence)
Entrez Gene12572 (Evidence)
UniGene259718
DoTSDT.101734497, DT.492514
EC2.7.11.22, 2.7.11.23
Consensus CDS ProjectCCDS36766.1
International Mouse Knockout Project StatusCdk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069089 Ensembl Gene Model | MGI Sequence Detail 33916 C57BL/6J ±  kb
transcript ENSMUST00000091299 Ensembl | MGI Sequence Detail 7595 Not Applicable 
polypeptide ENSMUSP00000088845 Ensembl | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005265 cell division protein kinase 7
References (Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:183925 Ganuza M, et al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012 Apr 13;
All references(48)
Other
accession IDs
MGD-MRK-19684, MGD-MRK-2148, MGD-MRK-23792, MGI:2145207, MGI:2145266, MGI:88505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory