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Cdk7 Gene Detail
Summary
  • Symbol
    Cdk7
  • Name
    cyclin-dependent kinase 7
  • Synonyms
    Cdkn7, Crk4, CRK4 PK (CDC2-related-kinase-4 protein kinase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:102956
    NCBI Gene: 12572
  • Gene Overview
    MyGene.info: CDK7
Location & Maps
more
  • Sequence Map
    Chr13:100697027-100730942 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33916 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    CDK7, cyclin dependent kinase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK7, cyclin dependent kinase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAK, CAK1, CDKN7, HCAK, MO15, p39MO15, STK1
  • Links
    NCBI Gene ID: 1022
    neXtProt AC: NX_P50613

  • Chr Location
    5q12.1; chr5:69234795-69277430 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null allele exhibit abnormal trophoblast layer morphology, abnormal inner cell mass apoptosis, and complete embryonic lethality during peri-implantation stages. Homoyzgous null MEFs display absent fibroblast proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069089 Ensembl Gene Model | MGI Sequence Detail 33916 C57BL/6J ±  kb
transcript ENSMUST00000091299 Ensembl | MGI Sequence Detail 7595 Not Applicable  
polypeptide ENSMUSP00000088845 Ensembl | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 102
    Genomic 3
    cDNA 99

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19684, MGD-MRK-2148, MGD-MRK-23792, MGI:2145207, MGI:2145266, MGI:88505
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
  • Latest
    J:183925 Ganuza M, et al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012 Apr 13;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory