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Cdk7 Gene Detail
Summary
  • Symbol
    Cdk7
  • Name
    cyclin-dependent kinase 7
  • Synonyms
    Cdkn7, Crk4, CRK4 PK (CDC2-related-kinase-4 protein kinase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:102956
    NCBI Gene: 12572
  • Gene Overview
    MyGene.info: CDK7
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100702631-100730939 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102956
protein coding gene Chr13:100697024-100730942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020892
protein coding gene Chr13:102627189-102665664 (-)
A/J MGP_AJ_G0020843
protein coding gene Chr13:98638315-98676313 (-)
AKR/J MGP_AKRJ_G0020818
protein coding gene Chr13:101663022-101699366 (-)
BALB/cJ MGP_BALBcJ_G0020843
protein coding gene Chr13:99366591-99401637 (-)
C3H/HeJ MGP_C3HHeJ_G0020632
protein coding gene Chr13:101372886-101409259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021277
protein coding gene Chr13:105686075-105722065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018847
protein coding gene Chr13:94461598-94496924 (-)
CAST/EiJ MGP_CASTEiJ_G0020151
protein coding gene Chr13:100844348-100876900 (-)
CBA/J MGP_CBAJ_G0020594
protein coding gene Chr13:109857838-109895166 (-)
DBA/2J MGP_DBA2J_G0020718
protein coding gene Chr13:98415224-98451537 (-)
FVB/NJ MGP_FVBNJ_G0020700
protein coding gene Chr13:97159587-97193340 (-)
LP/J MGP_LPJ_G0020792
protein coding gene Chr13:102645025-102680001 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020728
protein coding gene Chr13:110103481-110133668 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021316
protein coding gene Chr13:101125429-101159108 (-)
PWK/PhJ MGP_PWKPhJ_G0019904
protein coding gene Chr13:97144567-97179993 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019726
protein coding gene Chr13:97353066-97386453 (-)
WSB/EiJ MGP_WSBEiJ_G0020209
protein coding gene Chr13:101589095-101625169 (-)



Homology
more
  • Human Ortholog
    CDK7, cyclin dependent kinase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK7, cyclin dependent kinase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAK, CAK1, CDKN7, HCAK, MO15, p39MO15, STK1
  • Links
    NCBI Gene ID: 1022
    neXtProt AC: NX_P50613
    UniProt: P50613

  • Chr Location
    5q13.2; chr5:69234795-69277430 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null allele exhibit abnormal trophoblast layer morphology, abnormal inner cell mass apoptosis, and complete embryonic lethality during peri-implantation stages. Homoyzgous null MEFs display absent fibroblast proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069089 Ensembl Gene Model | MGI Sequence Detail 28309 C57BL/6J ±  kb
    transcript ENSMUST00000091299 Ensembl | MGI Sequence Detail 1988 Not Applicable  
    polypeptide ENSMUSP00000088845 Ensembl | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 3
      cDNA 100

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19684, MGD-MRK-2148, MGD-MRK-23792, MGI:2145207, MGI:2145266, MGI:88505
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
    • Latest
      J:251483 Wang H, et al., Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis. Biochim Biophys Acta. 2016 Dec;1863(12):2993-3000

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory