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Dgka
Gene Detail
 Symbol
Name
ID
Dgka
diacylglycerol kinase, alpha
MGI:102952
Synonyms Dagk1
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:128720141-128744056 bp, - strand
From Ensembl annotation of GRCm38

  23916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1028  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: diacylglycerol kinase
Gene Tree: Dgka

Human
homologs
Human Homolog DGKA, diacylglycerol kinase, alpha 80kDa
NCBI Gene ID 1606
neXtProt AC  NX_P23743
Human Synonyms  DAGK, DAGK1, DGK-alpha
Human Chr (Location)  12q13.3; chr12:55931162-55954027 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(56) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired induction of T cell anergy. T cells stimulated in anergy producing conditions show increased proliferation and interleukin 2 production. Mice homozygous for a transgenic gene disruption exhibit male infertility.
 
Interactions
Dgka interacts with 88 markers (Mir18, Mir18b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process intracellular signal transduction, metabolic process, ...
Component cytosol, membrane, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (197)    Tissues (112)    Images (34)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 195
RT-PCR 2
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025357 (Evidence)
Entrez Gene13139 (Evidence)
UniGene291235
DFCITC1579717, TC1615518, TC1621634
NIA Mouse Gene IndexU032373
EC2.7.1.107
Consensus CDS ProjectCCDS24290.1
International Mouse Knockout Project StatusDgka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025357 Ensembl Gene Model | MGI Sequence Detail 23916 C57BL/6J ±  kb
transcript ENSMUST00000026414 Ensembl | MGI Sequence Detail 2808 Not Applicable 
polypeptide ENSMUSP00000026414 Ensembl | MGI Sequence Detail 730 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(17) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
Protein Ontology PR:000006442 diacylglycerol kinase alpha
References (Earliest) J:25236 Pilz A, et al., Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics. 1995 Apr 10;26(3):599-601
(Latest) J:198343 Riese MJ, et al., Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases. Cancer Res. 2013 Jun 15;73(12):3566-77
All references(55)
Other
accession IDs
MGD-MRK-23787, MGI:2143820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory