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Dgka
Gene Detail
Symbol

Name
ID
Dgka
diacylglycerol kinase, alpha
MGI:102952
Synonyms
Dagk1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:128720141-128744056 bp, - strand
From Ensembl annotation of GRCm38

  23916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1028  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DGKA
Protein SuperFamily: diacylglycerol kinase
Gene Tree: Dgka

Human
homologs
DGKA, diacylglycerol kinase, alpha 80kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1606
neXtProt AC: NX_P23743

Human Synonyms: DAGK, DAGK1, DGK-alpha

Human Chr (Location): 12q13.3; chr12:55931162-55954027 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(56) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in impaired induction of T cell anergy. T cells stimulated in anergy producing conditions show increased proliferation and interleukin 2 production. Mice homozygous for a transgenic gene disruption exhibit male infertility.
 
Interactions
Dgka interacts with 87 markers (Mir18, Mir18b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intracellular signal transduction, phosphorylation, ...
Component cytosol, membrane, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (197)    Tissues (112)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 195
RT-PCR 2
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dgka    NEW 
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025357 (Evidence)
Entrez Gene 13139 (Evidence)
UniGene 291235
DFCI TC1579717, TC1615518, TC1621634
NIA Mouse Gene Index U032373
EC 2.7.1.107
Consensus CDS Project CCDS24290.1
International Mouse Phenotyping Consortium Status Dgka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025357 Ensembl Gene Model | MGI Sequence Detail 23916 C57BL/6J ±  kb
transcript ENSMUST00000026414 Ensembl | MGI Sequence Detail 2808 Not Applicable 
polypeptide ENSMUSP00000026414 Ensembl | MGI Sequence Detail 730 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(32) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
Protein Ontology PR:000006442 diacylglycerol kinase alpha
References
(Earliest) J:25236 Pilz A, et al., Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics. 1995 Apr 10;26(3):599-601
(Latest) J:198343 Riese MJ, et al., Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases. Cancer Res. 2013 Jun 15;73(12):3566-77
All references(53)
Other
accession IDs
MGD-MRK-23787, MGI:2143820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory