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Dgka Gene Detail
Summary
  • Symbol
    Dgka
  • Name
    diacylglycerol kinase, alpha
  • Synonyms
    Dagk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102952
    NCBI Gene: 13139
  • Gene Overview
    MyGene.info: DGKA
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128720134-128744855 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102952
protein coding gene Chr10:128720134-128748420 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017880
protein coding gene Chr10:132492787-132533569 (-)
A/J MGP_AJ_G0017855
protein coding gene Chr10:127172518-127195526 (-)
AKR/J MGP_AKRJ_G0017818
protein coding gene Chr10:130887689-130913213 (-)
BALB/cJ MGP_BALBcJ_G0017819
protein coding gene Chr10:127537232-127554599 (-)
C3H/HeJ MGP_C3HHeJ_G0017642
protein coding gene Chr10:131057852-131081766 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018274
protein coding gene Chr10:136966752-137000555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015952
protein coding gene Chr10:121085306-121111046 (-)
CAST/EiJ MGP_CASTEiJ_G0017203
protein coding gene Chr10:131780435-131805639 (-)
CBA/J MGP_CBAJ_G0017612
protein coding gene Chr10:142559835-142589032 (-)
DBA/2J MGP_DBA2J_G0017718
protein coding gene Chr10:126231944-126256086 (-)
FVB/NJ MGP_FVBNJ_G0017713
protein coding gene Chr10:125155586-125173266 (-)
LP/J MGP_LPJ_G0017792
protein coding gene Chr10:133082499-133107545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017741
protein coding gene Chr10:145122281-145149616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018314
protein coding gene Chr10:130993201-131019251 (-)
PWK/PhJ MGP_PWKPhJ_G0016988
protein coding gene Chr10:126488908-126520072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016777
protein coding gene Chr10:130107404-130130508 (-)
WSB/EiJ MGP_WSBEiJ_G0017262
protein coding gene Chr10:131215697-131241225 (-)



Homology
more
  • Human Ortholog
    DGKA, diacylglycerol kinase alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGKA, diacylglycerol kinase alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAGK, DAGK1, DGK-alpha
  • Links
    NCBI Gene ID: 1606
    neXtProt AC: NX_P23743
    UniProt: P23743

  • Chr Location
    12q13.2; chr12:55931076-55954023 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired induction of T cell anergy. T cells stimulated in anergy producing conditions show increased proliferation and interleukin 2 production. Mice homozygous for a transgenic gene disruption exhibit male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025357 Ensembl Gene Model | MGI Sequence Detail 24722 C57BL/6J ±  kb
    transcript ENSMUST00000026414 Ensembl | MGI Sequence Detail 2834 Not Applicable  
    polypeptide ENSMUSP00000026414 Ensembl | MGI Sequence Detail 730 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 78
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23787, MGI:2143820
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:25236 Pilz A, et al., Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics. 1995 Apr 10;26(3):599-601
    • Latest
      J:257479 Nascimento EBM, et al., Diacylglycerol kinase alpha deficiency alters inflammation markers in adipose tissue in response to a high-fat diet. J Lipid Res. 2018 Feb;59(2):273-282

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory