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Scx Gene Detail
Summary
  • Symbol
    Scx
  • Name
    scleraxis
  • Synonyms
    bHLHa41, Scl
  • Feature Type
    protein coding gene
  • IDs
    MGI:102934
    NCBI Gene: 20289
  • Gene Overview
    MyGene.info: SCX
Location & Maps
more
  • Sequence Map
    Chr15:76457438-76459468 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2031 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.92 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SCX, scleraxis bHLH transcription factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SCX, scleraxis bHLH transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHa48, SCXA, SCXB
  • Links
    NCBI Gene ID: 642658
    neXtProt AC: NX_Q7RTU7

  • Chr Location
    8q24.3; chr8:144265060-144268483 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 5 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    5 involving Scx
  • Incidental Mutations
Homozygotes for a targeted mutation develop normally up to E6.0-E6.5, but become arrested and fail to gastrulate and form mesodermal cells. In chimeric embryos, mutant cells are excluded from sclerotome-derived chondrogenic lineages but contribute to other cell types, including mesodermal tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034161 Ensembl Gene Model | MGI Sequence Detail 2031 C57BL/6J ±  kb
transcript ENSMUST00000043089 Ensembl | MGI Sequence Detail 1136 Not Applicable  
polypeptide ENSMUSP00000043668 Ensembl | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014546 basic helix-loop-helix transcription factor scleraxis
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 29
    cDNA 15
    Primer pair 4
    Other 10

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-23768, MGI:2146261
References
more
  • Summaries
    All 115
    Developmental Gene Expression 77
    Diseases 1
    Gene Ontology 14
    Phenotypes 38
  • Earliest
    J:24330 Cserjesi P, et al., Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development. 1995 Apr;121(4):1099-110
  • Latest
    J:231581 Cesario JM, et al., Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016 Mar;20(2):111-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory