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Vcan Gene Detail
Summary
  • Symbol
    Vcan
  • Name
    versican
  • Synonyms
    5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:102889
    NCBI Gene: 13003
  • Gene Overview
    MyGene.info: VCAN
Location & Maps
more
  • Sequence Map
    Chr13:89655312-89742509 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87198 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 45.50 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    VCAN, versican
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VCAN, versican
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
  • Links
    NCBI Gene ID: 1462
    neXtProt AC: NX_P13611

  • Chr Location
    5q14.3; chr5:83471674-83582303 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human VCAN associations

Human Disease Mouse Models
       Wagner Vitreoretinopathy; WGVRP   OMIM: 143200
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    1 involving Vcan
  • Incidental Mutations
Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033531 VEGA Gene Model | MGI Sequence Detail 87198 C57BL/6J ±  kb
transcript OTTMUST00000084386 VEGA | MGI Sequence Detail 12427 Not Applicable  
polypeptide OTTMUSP00000045468 VEGA | MGI Sequence Detail 3354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    596 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 80
    Genomic 12
    cDNA 40
    Primer pair 23
    Other 5

    Microarray probesets 11
Other
Accession IDs
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MGD-MRK-23722, MGI:1918683, MGI:894331
References
more
  • Summaries
    All 123
    Developmental Gene Expression 72
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:22294 Ito K, et al., Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. J Biol Chem. 1995 Jan 13;270(2):958-65
  • Latest
    J:228583 Nandadasa S, et al., ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory