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Vcan
Gene Detail
Symbol

Name
ID
Vcan
versican
MGI:102889
Synonyms
5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M
Feature Type
protein coding gene
Genetic Map
Chromosome 13
45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr13:89655312-89742509 bp, - strand
From VEGA annotation of GRCm38

  87198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Vcan

Human
homologs
Human Homolog VCAN, versican
NCBI Gene ID 1462
neXtProt AC  NX_P13611
Human Synonyms  CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
Human Chr (Location)  5q14.3; chr5:83471674-83582303 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VCAN
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.
 
Phenotype Images(5)
Interactions
Vcan interacts with 430 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, glial cell migration, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (207)    Tissues (126)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 121
Western blot 21
RT-PCR 47
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(12) cDNA(40) Primer pair(23) Other(4)
Microarray probesets(11)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033531 VEGA Gene Model | MGI Sequence Detail 87198 C57BL/6J ±  kb
transcript OTTMUST00000084386 VEGA | MGI Sequence Detail 12427 Not Applicable 
polypeptide OTTMUSP00000045468 VEGA | MGI Sequence Detail 3354 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(18) UniProt(16)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(598 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000538 Link
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000017271 versican core protein
References
(Earliest) J:3534 Iozzo RV, et al., Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). Genomics. 1992 Dec;14(4):845-51
(Latest) J:213432 Burns TA, et al., Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles. PLoS One. 2014;9(2):e89133
All references(115)
Other
accession IDs
MGD-MRK-23722, MGI:1918683, MGI:894331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory