Vcan
Gene Detail

Symbol Name ID

Vcan versican MGI:102889

Synonyms

5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M

Feature Type

protein coding gene

Genetic Map

Chromosome 13

45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr13:89655312-89742509 bp, - strand From VEGA annotation of GRCm38   87198 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Vcan

Human homologs

Human Homolog		VCAN, versican
NCBI Gene ID		1462
neXtProt AC		NX_P13611
Human Synonyms		CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
Human Chr (Location)		5q14.3; chr5:82767493-82878122 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human VCAN

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(6) Transgenic(1)
 

Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cell adhesion, glial cell migration, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (59 records)
Data Summary: Results (115)    Tissues (78)    Images (35)
Theiler Stages: 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	89
RT-PCR	25

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(73) Genomic(12) cDNA(40) Primer pair(17) Other(4)
Microarray probesets(11)

Other database links

VEGA Gene Model	OTTMUSG00000033531 (Evidence)
Ensembl Gene Model	ENSMUSG00000021614 (Evidence)
Entrez Gene	13003 (Evidence)
DFCI	TC1578893, TC1588416, TC1591070, TC1597581, TC1604884, TC1613353, TC1621288, TC1623993, TC1625061, TC1660667, TC1718370
DoTS	DT.101232728, DT.529191, DT.91338492, DT.91356560, DT.91400302, DT.91443381, DT.94222309, DT.97399205
NIA Mouse Gene Index	U035008, U054519, U054521, U371999
Consensus CDS Project	CCDS36740.1, CCDS49321.1, CCDS49322.1, CCDS49323.1, CCDS49324.1
International Mouse Knockout Project Status	Vcan

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033531	VEGA Gene Model | MGI Sequence Detail	87198	C57BL/6J
transcript	OTTMUST00000084386	VEGA | MGI Sequence Detail	12427	Not Applicable
polypeptide	OTTMUSP00000045468	VEGA | MGI Sequence Detail	3354	Not Applicable

All sequences(117) RefSeq(10) UniProt(16)

Polymorphisms

All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs(538 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR000538	Link
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000017271	versican core protein

References

(Earliest) J:3534 Iozzo RV, et al., Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). Genomics. 1992 Dec;14(4):845-51
(Latest) J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
All references(108)

Other accession IDs

MGD-MRK-23722, MGI:1918683, MGI:894331