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Vcan Gene Detail
Summary
  • Symbol
    Vcan
  • Name
    versican
  • Synonyms
    5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:102889
    NCBI Gene: 13003
  • Gene Overview
    MyGene.info: VCAN
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:89655312-89742509 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87198 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 45.50 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    VCAN, versican
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VCAN, versican
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
  • Links
    NCBI Gene ID: 1462
    neXtProt AC: NX_P13611
    UniProt: P13611

  • Chr Location
    5q14.2-q14.3; chr5:83471674-83582303 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033531 VEGA Gene Model | MGI Sequence Detail 87198 C57BL/6J ±  kb
    transcript OTTMUST00000084386 VEGA | MGI Sequence Detail 12427 Not Applicable  
    polypeptide OTTMUSP00000045468 VEGA | MGI Sequence Detail 3354 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      596 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 12
      cDNA 39
      Primer pair 26
      Other 7

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-23722, MGI:1918683, MGI:894331
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 80
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:258360 Lin W, et al., Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018 Feb 1;128(2):826-833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory