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Vcan
Gene Detail
Symbol

Name
ID
Vcan
versican
MGI:102889
Synonyms
5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M
Feature Type
protein coding gene
Genetic Map
Chromosome 13
45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr13:89655312-89742509 bp, - strand
From VEGA annotation of GRCm38

  87198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: VCAN
Gene Tree: Vcan

Human
homologs
VCAN, versican
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1462
neXtProt AC: NX_P13611

Human Synonyms: CSPG2, ERVR, GHAP, PG-M, WGN, WGN1

Human Chr (Location): 5q14.3; chr5:83471674-83582303 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VCAN

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.
 
Phenotype Images(5)
Interactions
Vcan interacts with 430 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell adhesion, central nervous system development, ...
Component cell surface, extracellular matrix, ...
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (207)    Tissues (126)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 121
Western blot 21
RT-PCR 47
cDNA source data(37)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA VCAN ; Xenbase vcan ; ZFIN vcanb    NEW 
Molecular
reagents
All nucleic(79) Genomic(12) cDNA(40) Primer pair(23) Other(4)
Microarray probesets(11)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033531 VEGA Gene Model | MGI Sequence Detail 87198 C57BL/6J ±  kb
transcript OTTMUST00000084386 VEGA | MGI Sequence Detail 12427 Not Applicable 
polypeptide OTTMUSP00000045468 VEGA | MGI Sequence Detail 3354 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(14) UniProt(16)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(598 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000538 Link
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000017271 versican core protein
References
(Earliest) J:22294 Ito K, et al., Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. J Biol Chem. 1995 Jan 13;270(2):958-65
(Latest) J:219895 Baalman K, et al., Axon initial segment-associated microglia. J Neurosci. 2015 Feb 4;35(5):2283-92
All references(120)
Other
accession IDs
MGD-MRK-23722, MGI:1918683, MGI:894331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory