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Elk4
Gene Detail
Symbol

Name
ID
Elk4
ELK4, member of ETS oncogene family
MGI:102853
Synonyms
2310011G17Rik, A130026I01Rik, Sap1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.24 cM, cytoband E3-G
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:132007607-132032612 bp, + strand
From VEGA annotation of GRCm38

  25006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: elk-1 transforming protein
Gene Tree: Elk4

Human
homologs
Human Homolog ELK4, ELK4, ETS-domain protein (SRF accessory protein 1)
NCBI Gene ID 2005
neXtProt AC  NX_P28324
Human Synonyms  SAP1
Human Chr (Location)  1q32; chr1:205598471-205633829 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mutation of this locus impairs thymocyte positive selection and results in reduced numbers of single-positive thymocytes and peripheral T cells.
 
Interactions
Elk4 interacts with 272 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, histone H3 deacetylation, ...
Component cytoplasm, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (191)    Tissues (88)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 191
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000024989 (Evidence)
Ensembl Gene ModelENSMUSG00000026436 (Evidence)
Entrez Gene13714 (Evidence)
DFCITC1618779, TC1592296, TC1615010, TC1602720, TC1602385
DoTSDT.101360326, DT.40143522, DT.493174, DT.94246147, DT.94122692
NIA Mouse Gene IndexU000792
Consensus CDS ProjectCCDS35704.1
International Mouse Knockout Project StatusElk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024989 VEGA Gene Model | MGI Sequence Detail 25006 C57BL/6J ±  kb
transcript OTTMUST00000061502 VEGA | MGI Sequence Detail 4433 Not Applicable 
polypeptide OTTMUSP00000030178 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(14) UniProt(15)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007027 ETS domain-containing protein Elk-4
References
(Earliest) J:19206 Giovane A, et al., Net, a new ets transcription factor that is activated by Ras. Genes Dev. 1994 Jul 1;8(13):1502-13
(Latest) J:201346 Weinl C, et al., Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. J Clin Invest. 2013 May 1;123(5):2193-206
All references(48)
Other
accession IDs
MGD-MRK-23686, MGI:1916854, MGI:2138642, MGI:2441777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory