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Elk4 Gene Detail
Summary
  • Symbol
    Elk4
  • Name
    ELK4, member of ETS oncogene family
  • Synonyms
    2310011G17Rik, A130026I01Rik, Sap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102853
    NCBI Gene: 13714
Location & Maps
more
  • Sequence Map
    Chr1:132007607-132032612 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25006 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ELK4, ELK4, ETS-domain protein (SRF accessory protein 1)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELK4, ELK4, ETS-domain protein (SRF accessory protein 1)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SAP1
  • Links
    NCBI Gene ID: 2005
    neXtProt AC: NX_P28324

  • Chr Location
    1q32; chr1:205593466-205634085 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Elk4
  • Incidental Mutations
    APF
Mutation of this locus impairs thymocyte positive selection and results in reduced numbers of single-positive thymocytes and peripheral T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024989 VEGA Gene Model | MGI Sequence Detail 25006 C57BL/6J ±  kb
transcript OTTMUST00000061502 VEGA | MGI Sequence Detail 4433 Not Applicable  
polypeptide OTTMUSP00000030178 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    138 from dbSNP Build 137
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000007027 ETS domain-containing protein Elk-4
  • InterPro Domains
    IPR000418 Ets domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-23686, MGI:1916854, MGI:2138642, MGI:2441777
References
more
  • Summaries
    All 44
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:19206 Giovane A, et al., Net, a new ets transcription factor that is activated by Ras. Genes Dev. 1994 Jul 1;8(13):1502-13
  • Latest
    J:201346 Weinl C, et al., Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. J Clin Invest. 2013 May 1;123(5):2193-206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory