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Klk1
Gene Detail
 Symbol
Name
ID
Klk1
kallikrein 1
MGI:102850
STS D7Mit26, D7Mit27
Synonyms 0610007D04Rik, Klk6, mGk-6
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr7:44225437-44229617 bp, + strand
From NCBI annotation of GRCm38

  4181 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1

Human
homologs
Human Homolog KLK3, kallikrein-related peptidase 3
NCBI Gene ID 354
neXtProt AC  NX_P07288
Human Synonyms  APS, hK3, KLK2A1, PSA
Human Chr (Location)  19q13.41; chr19:50854915-50860764 (+)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1 interacts with 13 markers (Mir214, Mir296, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process proteolysis
Component nucleus
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (72)    Tissues (9)   
Theiler Stages: 1, 2, 4, 11, 15, 18, 28
Assay TypeResults
RT-PCR 72
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) Genomic(82) cDNA(9) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000063903 (Evidence)
Entrez Gene16612 (Evidence)
EC3.4.21.35
Consensus CDS ProjectCCDS21202.1
International Mouse Knockout Project StatusKlk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16612 NCBI Gene Model | MGI Sequence Detail 4181 C57BL/6J ±  kb
transcript NM_010639 RefSeq | MGI Sequence Detail 876 C57BL/6 
polypeptide P15947 UniProt | EBI | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(6) : PCR(4) RFLP(2) SNPs within 2kb(49 from dbSNP Build 137)    SNPs within 2kb including multiple locations(149)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009406 kallikrein-1
Graphical View of Protein Domain Structure
References (Earliest) J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
(Latest) J:195036 Karn RC, et al., Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes. PLoS One. 2011;6(6):e20979
All references(53)
Other
accession IDs
MGD-MRK-11548, MGD-MRK-23683, MGI:1915579

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory