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Klk1 Gene Detail
Summary
  • Symbol
    Klk1
  • Name
    kallikrein 1
  • Synonyms
    0610007D04Rik, Klk6, mGk-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:102850
    NCBI Gene: 16612
Location & Maps
more
  • Sequence Map
    Chr7:44225437-44229617 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4181 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KLK1, kallikrein 1
  • Vertebrate Orthologs
    16
  • Human Ortholog
    KLK1, kallikrein 1
    Orthology source: HGNC
  • Synonyms
    hK1, Klk6, KLKR
  • Links
    NCBI Gene ID: 3816
    neXtProt AC: NX_P06870

  • Chr Location
    19q13.3; chr19:50819146-50823787 (-)  GRCh38.p2

  • Human Ortholog
    KLK3, kallikrein related peptidase 3
    Orthology source: HomoloGene
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288

  • Chr Location
    19q13.41; chr19:50854915-50877702 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KLK1 associations

Human Disease Mouse Models
       Kallikrein, Decreased Urinary Activity of   OMIM: 615953
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16612 NCBI Gene Model | MGI Sequence Detail 4181 C57BL/6J ±  kb
transcript NM_010639 RefSeq | MGI Sequence Detail 876 C57BL/6  
polypeptide P15947 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    91 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    Genomic 82
    cDNA 9
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11548, MGD-MRK-23683, MGI:1915579
References
more
  • Summaries
    All 54
    Developmental Gene Expression 7
    Gene Ontology 4
  • Earliest
    J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
  • Latest
    J:219373 Islam MN, et al., Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015 Mar;244(3):488-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory