Klk1 MGI Mouse Gene Detail - MGI:102850

Symbol

Klk1
Name

kallikrein 1
Synonyms

0610007D04Rik, Klk6, mGk-6

Feature Type

protein coding gene
IDs

MGI:102850
NCBI Gene: 16612
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr7:43874784-43879042 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 28.74 cM
Mapping Data

16 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

14
PCR

4
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102850	protein coding gene	Chr7:43874784-43879046 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032151	protein coding gene	Chr7:44036549-44373083 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0032064	protein coding gene	Chr7:44486267-44500293 (+)
BALB/cJ	MGP_BALBcJ_G0032139	protein coding gene	Chr7:43273636-43326579 (+)
C3H/HeJ	MGP_C3HHeJ_G0031856	protein coding gene	Chr7:44992784-45248852 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032636	protein coding gene	Chr7:46613583-46619247 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029651	protein coding gene	Chr7:45867177-45871639 (+)
CAST/EiJ	MGP_CASTEiJ_G0031187	protein coding gene	Chr7:36203533-36205588 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0031975	protein coding gene	Chr7:42911408-42915912 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0032054	protein coding gene	Chr7:44776026-45057670 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0032652	protein coding gene	Chr7:43980443-43984701 (+)
PWK/PhJ	MGP_PWKPhJ_G0030909	protein coding gene	Chr7:36371439-36373504 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030745	protein coding gene	Chr7:31661862-31663938 (+)
WSB/EiJ	MGP_WSBEiJ_G0031301	protein coding gene	Chr7:44180419-44192006 (+)

Human Ortholog

KLK1, kallikrein 1

Vertebrate Orthologs

14

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLK1, kallikrein 1
Synonyms

hK1, Klk6, KLKR
Links

HGNC:6357

NCBI Gene ID: 3816

neXtProt AC: NX_P06870

UniProt: P06870
Chr Location

19q13.33; chr19:50819146-50823787 (-) GRCh38

Human Ortholog

KLK2, kallikrein related peptidase 2
Synonyms

hGK-1, hK2, KLK2A2
Links

HGNC:6363

NCBI Gene ID: 3817

neXtProt AC: NX_P20151

UniProt: P20151
Chr Location

19q13.33; chr19:50861568-50880567 (+) GRCh38

Human Ortholog

KLK3, kallikrein related peptidase 3
Synonyms

APS, hK3, KLK2A1, PSA
Links

HGNC:6364

NCBI Gene ID: 354

neXtProt AC: NX_P07288

UniProt: P07288
Chr Location

19q13.33; chr19:50854915-50860764 (+) GRCh38

MGI Vertebrate Homology

Klk1 stringent orthology
3 human;1 mouse;11 rat
HCOP

vertebrate homology predictions: KLK1, KLK2, KLK3
Gene Tree

Klk1

Diseases

5 with human KLK1 associations

				Human Disease	Mouse Models
				cardiomyopathy IDs cardiomyopathy DOID:0050700 ICD10CM:I42 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544
				chronic kidney disease IDs chronic kidney disease DOID:784 ICD10CM:N18.9 ICD9CM:585 ICD9CM:585.6 MESH:D007676 NCI:C9438 UMLS_CUI:C0022661
				end stage renal disease IDs end stage renal disease DOID:783
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

11
cDNA Data

7
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klk1

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All Sequences

39
RefSeq

6
UniProt

3
CCDS

CCDS21202.1

Ensembl

ENSMUSG00000063903 (Evidence)
NCBI Gene

16612

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063903	Ensembl Gene Model \| MGI Sequence Detail	4259	C57BL/6J	± kb
transcript	ENSMUST00000075162	Ensembl \| MGI Sequence Detail	954	Not Applicable
polypeptide	ENSMUSP00000074659	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

3 Sequences
EC

3.4.21.35
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

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All nucleic 97

Genomic 82

cDNA 10

Primer pair 5

Microarray probesets 5

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MGD-MRK-11548, MGD-MRK-23683, MGI:1915579

Summaries

All 82

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 19
Earliest

J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
Latest

J:256467 Desposito D, et al., Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice. Sci Rep. 2017 Aug 25;7(1):9410

TSS for Klk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66116	Chr7:43874752-43874783 (+)	-16 bp
Tssr66117	Chr7:43874854-43874875 (+)	81 bp
Tssr66118	Chr7:43877046-43877055 (+)	2,267 bp
Tssr66119	Chr7:43877768-43877780 (+)	2,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23