Klkb1
Gene Detail

Symbol Name ID

Klkb1 kallikrein B, plasma 1 MGI:102849

Synonyms

Kal3, Kal-3, Klk3, PSA

Feature Type

protein coding gene

Genetic Map

Chromosome 8

25.17 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr8:45269442-45294859 bp, - strand From VEGA annotation of GRCm38   25418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: plasma kallikrein/coagulation factor XI
Gene Tree: Klkb1

Human homologs

Human Homolog		KLKB1, kallikrein B, plasma (Fletcher factor) 1
NCBI Gene ID		3818
neXtProt AC		NX_P03952
Human Synonyms		KLK3, PPK
Human Chr (Location)		4q35; chr4:187148672-187179625 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KLKB1

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	blood coagulation, fibrinolysis, ...
Component	extracellular region, extracellular space
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (32)    Tissues (4)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	32

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(19) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033163 (Evidence)
Ensembl Gene Model	ENSMUSG00000031640 (Evidence)
Entrez Gene	16621 (Evidence)
UniGene	482691
DFCI	TC1583928
DoTS	DT.91411616
EC	3.4.21.34
Consensus CDS Project	CCDS22275.1
International Mouse Knockout Project Status	Klkb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033163	VEGA Gene Model | MGI Sequence Detail	25418	C57BL/6J
transcript	OTTMUST00000082939	VEGA | MGI Sequence Detail	2496	Not Applicable
polypeptide	OTTMUSP00000044498	VEGA | MGI Sequence Detail	638	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

PCR(2) : SNPs(562 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000177	Apple domain
InterPro	IPR003609	Apple-like
InterPro	IPR003014	PAN-1 domain
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000009420	plasma kallikrein

References

(Earliest) J:10905 Seidah NG, et al., Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species. DNA Cell Biol. 1990 Dec;9(10):737-48
(Latest) J:178810 Revenko AS, et al., Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood. 2011 Nov 10;118(19):5302-11
All references(34)

Other accession IDs

MGD-MRK-11549, MGD-MRK-11550, MGD-MRK-23682