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Klkb1
Gene Detail
Symbol

Name
ID
Klkb1
kallikrein B, plasma 1
MGI:102849
Synonyms
Kal3, Kal-3, Klk3, PSA
Feature Type
protein coding gene
Genetic Map
Chromosome 8
25.17 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr8:45269442-45294859 bp, - strand
From VEGA annotation of GRCm38

  25418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

HCOP human homology predictions: KLKB1
Protein SuperFamily: plasma kallikrein/coagulation factor XI
Gene Tree: Klkb1

Human
homologs
KLKB1, kallikrein B, plasma (Fletcher factor) 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3818
neXtProt AC: NX_P03952

Human Synonyms: KLK3, PKKD, PPK

Human Chr (Location): 4q35; chr4:186210753-186258474 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KLKB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced hematoma expansion in streptozotocin-induced diabetic mice subjected to autologous blood injection, and prolonged activated partial thromboplastin time.
 
Interactions
Klkb1 interacts with 95 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process blood coagulation, fibrinolysis, ...
Component extracellular exosome, extracellular region, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (32)    Tissues (4)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 32
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klkb1    NEW 
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(19) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000033163 (Evidence)
Ensembl Gene Model ENSMUSG00000031640 (Evidence)
Entrez Gene 16621 (Evidence)
UniGene 482691
DFCI TC1583928
DoTS DT.91411616
EC 3.4.21.34
Consensus CDS Project CCDS22275.1
International Mouse Phenotyping Consortium Status Klkb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033163 VEGA Gene Model | MGI Sequence Detail 25418 C57BL/6J ±  kb
transcript OTTMUST00000082939 VEGA | MGI Sequence Detail 2496 Not Applicable 
polypeptide OTTMUSP00000044498 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms
PCR(2) : SNPs within 2kb(489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000177 Apple domain
InterPro IPR003609 PAN/Apple domain
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000009420 plasma kallikrein
References
(Earliest) J:10905 Seidah NG, et al., Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species. DNA Cell Biol. 1990 Dec;9(10):737-48
(Latest) J:221214 Boisset JC, et al., Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta. Blood. 2015 Jan 15;125(3):465-9
All references(38)
Other
accession IDs
MGD-MRK-11549, MGD-MRK-11550, MGD-MRK-23682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory