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Klkb1
Gene Detail
Symbol

Name
ID
Klkb1
kallikrein B, plasma 1
MGI:102849
Synonyms
Kal3, Kal-3, Klk3, PSA
Feature Type
protein coding gene
Genetic Map
Chromosome 8
25.17 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr8:45269442-45294859 bp, - strand
From VEGA annotation of GRCm38

  25418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: plasma kallikrein/coagulation factor XI
Gene Tree: Klkb1

Human
homologs
Human Homolog KLKB1, kallikrein B, plasma (Fletcher factor) 1
NCBI Gene ID 3818
neXtProt AC  NX_P03952
Human Synonyms  KLK3, PPK
Human Chr (Location)  4q35; chr4:186227352-186258473 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KLKB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced hematoma expansion in streptozotocin-induced diabetic mice subjected to autologous blood injection, and prolonged activated partial thromboplastin time.
 
Interactions
Klkb1 interacts with 95 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process blood coagulation, fibrinolysis, ...
Component extracellular region, extracellular space, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (32)    Tissues (4)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 32
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(19) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033163 (Evidence)
Ensembl Gene ModelENSMUSG00000031640 (Evidence)
Entrez Gene16621 (Evidence)
UniGene482691
DFCITC1583928
DoTSDT.91411616
EC3.4.21.34
Consensus CDS ProjectCCDS22275.1
International Mouse Knockout Project StatusKlkb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033163 VEGA Gene Model | MGI Sequence Detail 25418 C57BL/6J ±  kb
transcript OTTMUST00000082939 VEGA | MGI Sequence Detail 2496 Not Applicable 
polypeptide OTTMUSP00000044498 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(4) UniProt(1)
Polymorphisms
PCR(2) : SNPs within 2kb(489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000177 Apple domain
InterPro IPR003609 Apple-like
InterPro IPR003014 PAN-1 domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009420 plasma kallikrein
References
(Earliest) J:10905 Seidah NG, et al., Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species. DNA Cell Biol. 1990 Dec;9(10):737-48
(Latest) J:178810 Revenko AS, et al., Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood. 2011 Nov 10;118(19):5302-11
All references(37)
Other
accession IDs
MGD-MRK-11549, MGD-MRK-11550, MGD-MRK-23682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory