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Fgl1
Gene Detail
Symbol

Name
ID
Fgl1
fibrinogen-like protein 1
MGI:102795
Synonyms
MGC:37822
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:41191434-41215156 bp, - strand
From VEGA annotation of GRCm38

  23723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGL1
Gene Tree: Fgl1

Human
homologs
FGL1, fibrinogen-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2267
neXtProt AC: NX_Q08830

Human Synonyms: HFREP1, HP-041, LFIRE1, LFIRE-1

Human Chr (Location): 8p22; chr8:17864391-17895538 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient.
 
Phenotype Images(3)
Interactions
Fgl1 interacts with 24 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process adipose tissue development, cholesterol metabolic process, ...
Component extracellular exosome, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fgl1    NEW 
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000034038 (Evidence)
Ensembl Gene Model ENSMUSG00000031594 (Evidence)
Entrez Gene 234199 (Evidence)
UniGene 277955
DFCI TC1581277
DoTS DT.534737, DT.94197348
NIA Mouse Gene Index U029754
Consensus CDS Project CCDS22260.1
International Mouse Phenotyping Consortium Status Fgl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034038 VEGA Gene Model | MGI Sequence Detail 23723 C57BL/6J ±  kb
transcript OTTMUST00000085951 VEGA | MGI Sequence Detail 1120 Not Applicable 
polypeptide OTTMUSP00000046479 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(327 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007508 fibrinogen-like protein 1
References
(Earliest) J:23981 Yamamoto T, et al., Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem Biophys Res Commun. 1993 Jun 15;193(2):681-7
(Latest) J:199844 Demchev V, et al., Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One. 2013;8(3):e58084
All references(28)
Other
accession IDs
MGD-MRK-19703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory