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Fgl1 Gene Detail
Summary
  • Symbol
    Fgl1
  • Name
    fibrinogen-like protein 1
  • Synonyms
    MGC:37822
  • Feature Type
    protein coding gene
  • IDs
    MGI:102795
    NCBI Gene: 234199
Location & Maps
more
  • Sequence Map
    Chr8:41191434-41215156 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23723 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FGL1, fibrinogen like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGL1, fibrinogen like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HFREP1, HP-041, LFIRE1, LFIRE-1
  • Links
    NCBI Gene ID: 2267
    neXtProt AC: NX_Q08830

  • Chr Location
    8p22; chr8:17864391-17895538 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034038 VEGA Gene Model | MGI Sequence Detail 23723 C57BL/6J ±  kb
transcript OTTMUST00000085951 VEGA | MGI Sequence Detail 1120 Not Applicable  
polypeptide OTTMUSP00000046479 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    327 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007508 fibrinogen-like protein 1
  • InterPro Domains
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
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  • All nucleic 30
    cDNA 30

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-19703
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:23981 Yamamoto T, et al., Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem Biophys Res Commun. 1993 Jun 15;193(2):681-7
  • Latest
    J:199844 Demchev V, et al., Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One. 2013;8(3):e58084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory