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Fgl1 Gene Detail
Summary
  • Symbol
    Fgl1
  • Name
    fibrinogen-like protein 1
  • Synonyms
    MGC:37822
  • Feature Type
    protein coding gene
  • IDs
    MGI:102795
    NCBI Gene: 234199
  • Gene Overview
    MyGene.info: FGL1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41191434-41215156 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102795
protein coding gene Chr8:41191434-41217978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033560
protein coding gene Chr8:40028132-40050990 (-)
A/J MGP_AJ_G0033543
protein coding gene Chr8:38504097-38526964 (-)
AKR/J MGP_AKRJ_G0033466
protein coding gene Chr8:39667133-39690024 (-)
BALB/cJ MGP_BALBcJ_G0033538
protein coding gene Chr8:38626197-38649064 (-)
C3H/HeJ MGP_C3HHeJ_G0033248
protein coding gene Chr8:40057297-40080882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034054
protein coding gene Chr8:41543420-41571687 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031003
protein coding gene Chr8:35157045-35182206 (-)
CAST/EiJ MGP_CASTEiJ_G0032576
protein coding gene Chr8:39552369-39578222 (-)
CBA/J MGP_CBAJ_G0033226
protein coding gene Chr8:43260086-43282981 (-)
DBA/2J MGP_DBA2J_G0033380
protein coding gene Chr8:38335800-38358668 (-)
FVB/NJ MGP_FVBNJ_G0033324
protein coding gene Chr8:37919047-37941938 (-)
LP/J MGP_LPJ_G0033469
protein coding gene Chr8:40063441-40086302 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033366
protein coding gene Chr8:43015345-43038455 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034072
protein coding gene Chr8:39819810-39842671 (-)
PWK/PhJ MGP_PWKPhJ_G0032285
protein coding gene Chr8:37882245-37909233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032117
protein coding gene Chr8:38986981-39013149 (-)
WSB/EiJ MGP_WSBEiJ_G0032691
protein coding gene Chr8:40027069-40049900 (-)



Homology
more
  • Human Ortholog
    FGL1, fibrinogen like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGL1, fibrinogen like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HFREP1, HP-041, LFIRE1, LFIRE-1
  • Links
    NCBI Gene ID: 2267
    neXtProt AC: NX_Q08830
    UniProt: Q08830

  • Chr Location
    8p22; chr8:17864380-17909983 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031594 Ensembl Gene Model | MGI Sequence Detail 23723 C57BL/6J ±  kb
    transcript ENSMUST00000034003 Ensembl | MGI Sequence Detail 1120 Not Applicable  
    polypeptide ENSMUSP00000034003 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007508 fibrinogen-like protein 1
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-19703
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:23981 Yamamoto T, et al., Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Biochem Biophys Res Commun. 1993 Jun 15;193(2):681-7
    • Latest
      J:232513 Nayeb-Hashemi H, et al., Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. Biochem Biophys Res Commun. 2015 Sep 18;465(2):167-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory