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Akap4 Gene Detail
Summary
  • Symbol
    Akap4
  • Name
    A kinase (PRKA) anchor protein 4
  • Synonyms
    Fsc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102794
    NCBI Gene: 11643
  • Gene Overview
    MyGene.info: AKAP4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7067519-7078609 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102794
protein coding gene ChrX:7067515-7078609 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035508
protein coding gene ChrX:1650525-1660933 (+)
A/J MGP_AJ_G0035486
protein coding gene ChrX:1625295-1635930 (+)
AKR/J MGP_AKRJ_G0035419
protein coding gene ChrX:1707487-1718302 (+)
BALB/cJ MGP_BALBcJ_G0035482
protein coding gene ChrX:1657115-1667811 (+)
C3H/HeJ MGP_C3HHeJ_G0035190
protein coding gene ChrX:1688174-1711166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036006
protein coding gene ChrX:1724217-1735143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032881
protein coding gene ChrX:1191162-1201648 (+)
CAST/EiJ MGP_CASTEiJ_G0034490
protein coding gene ChrX:1580969-1592566 (+)
CBA/J MGP_CBAJ_G0035160
protein coding gene ChrX:1819570-1833025 (+)
DBA/2J MGP_DBA2J_G0035317
protein coding gene ChrX:1665574-1676132 (+)
FVB/NJ MGP_FVBNJ_G0035264
protein coding gene ChrX:1624116-1634134 (+)
LP/J MGP_LPJ_G0035394
protein coding gene ChrX:1660463-1671975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035303
protein coding gene ChrX:1792657-1803124 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036024
protein coding gene ChrX:1652571-1662810 (+)
PWK/PhJ MGP_PWKPhJ_G0034192
protein coding gene ChrX:1578237-1589576 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034029
protein coding gene ChrX:1588503-1604697 (+)
WSB/EiJ MGP_WSBEiJ_G0034613
protein coding gene ChrX:1651746-1664068 (+)



Homology
more
  • Human Ortholog
    AKAP4, A-kinase anchoring protein 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKAP4, A-kinase anchoring protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKAP-4, AKAP82, AKAP 82, CT99, FSC1, hAKAP82, HI, p82, PRKA4
  • Links
    NCBI Gene ID: 8852
    neXtProt AC: NX_Q5JQC9
    UniProt: Q5JQC9

  • Chr Location
    Xp11.22; chrX:50190768-50201013 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus results in male infertility due to impaired sperm motility. Heterozygous mutant females show no reproductive defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050089 Ensembl Gene Model | MGI Sequence Detail 11091 C57BL/6J ±  kb
transcript ENSMUST00000057101 Ensembl | MGI Sequence Detail 2851 Not Applicable  
polypeptide ENSMUSP00000050962 Ensembl | MGI Sequence Detail 849 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 5
    cDNA 23
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-19702
References
more
  • Summaries
    All 37
    Gene Ontology 13
    Phenotypes 2
  • Earliest
    J:20326 Carrera A, et al., The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994 Sep;165(1):272-84
  • Latest
    J:202175 Riddle RC, et al., Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. PLoS One. 2013;8(5):e63323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory