About   Help   FAQ
Akap4
Gene Detail
 Symbol
Name
ID
Akap4
A kinase (PRKA) anchor protein 4
MGI:102794
Synonyms Fsc1
Feature Type protein coding gene
Genetic Map
Chromosome X
3.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:7067519-7078609 bp, + strand
From VEGA annotation of GRCm38

  11091 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2887  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Akap4

Human
homologs
Human Homolog AKAP4, A kinase (PRKA) anchor protein 4
NCBI Gene ID 8852
neXtProt AC  NX_Q5JQC9
Human Synonyms  AKAP-4, AKAP82, AKAP 82, CT99, FSC1, hAKAP82, HI, p82, PRKA4
Human Chr (Location)  Xp11.2; chrX:50190768-50201013 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Inactivation of this locus results in male infertility due to impaired sperm motility. Heterozygous mutant females show no reproductive defects.
 
Interactions
Akap4 interacts with 82 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell projection organization, phosphorylation, ...
Component cell projection, cilium, ...
Function kinase activity, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(22)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(5) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016457 (Evidence)
Ensembl Gene ModelENSMUSG00000050089 (Evidence)
Entrez Gene11643 (Evidence)
UniGene1498
DFCITC1584318, TC1594337, TC1659483
DoTSDT.101215767, DT.101276903, DT.60104416, DT.91333252, DT.99845942
NIA Mouse Gene IndexU019654
Consensus CDS ProjectCCDS40838.1, CCDS40839.1
International Mouse Knockout Project StatusAkap4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016457 VEGA Gene Model | MGI Sequence Detail 11091 C57BL/6J ±  kb
transcript OTTMUST00000039653 VEGA | MGI Sequence Detail 2851 Not Applicable 
polypeptide OTTMUSP00000017697 VEGA | MGI Sequence Detail 849 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020799 A-kinase anchor 110kDa
InterPro IPR018292 A-kinase anchor 110kDa, C-terminal
InterPro IPR018459 RII binding domain
InterPro IPR008382 SPHK1-interactor/A-kinase anchor 110kDa
Protein Ontology PR:000003891 A-kinase anchor protein 4
References (Earliest) J:20326 Carrera A, et al., The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994 Sep;165(1):272-84
(Latest) J:202175 Riddle RC, et al., Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. PLoS One. 2013;8(5):e63323
All references(38)
Other
accession IDs
MGD-MRK-19702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory