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Akap4 Gene Detail
Summary
  • Symbol
    Akap4
  • Name
    A kinase (PRKA) anchor protein 4
  • Synonyms
    Fsc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102794
    NCBI Gene: 11643
  • Gene Overview
    MyGene.info: AKAP4
Location & Maps
more
  • Genetic Map
    Chromosome X, 3.17 cM
  • Mapping Data
    4 experiments
Homology
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  • Human Ortholog
    AKAP4, A-kinase anchoring protein 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKAP4, A-kinase anchoring protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AKAP-4, AKAP82, AKAP 82, CT99, FSC1, hAKAP82, HI, p82, PRKA4
  • Links
    NCBI Gene ID: 8852
    neXtProt AC: NX_Q5JQC9

  • Chr Location
    Xp11.2; chrX:50190768-50201013 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
  • Incidental Mutations
    APF
Inactivation of this locus results in male infertility due to impaired sperm motility. Heterozygous mutant females show no reproductive defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016457 VEGA Gene Model | MGI Sequence Detail 11091 C57BL/6J ±  kb
transcript OTTMUST00000039653 VEGA | MGI Sequence Detail 2851 Not Applicable  
polypeptide OTTMUSP00000017697 VEGA | MGI Sequence Detail 849 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003891 A-kinase anchor protein 4
  • InterPro Domains
    IPR020799 A-kinase anchor 110kDa
    IPR018292 A-kinase anchor 110kDa, C-terminal
    IPR018459 RII binding domain
    IPR008382 SPHK1-interactor/A-kinase anchor 110kDa
Molecular
Reagents
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  • All nucleic 28
    Genomic 5
    cDNA 22
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19702
References
more
  • Summaries
    All 35
    Gene Ontology 12
    Phenotypes 2
  • Earliest
    J:20326 Carrera A, et al., The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994 Sep;165(1):272-84
  • Latest
    J:202175 Riddle RC, et al., Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. PLoS One. 2013;8(5):e63323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory