Akap4 MGI Mouse Gene Detail - MGI:102794 - A kinase anchor protein 4

Symbol

Akap4
Name

A kinase anchor protein 4
Synonyms

Fsc1

Feature Type

protein coding gene
IDs

MGI:102794
NCBI Gene: 11643
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:6933758-6944848 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 3.17 cM
Mapping Data

4 experiments

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102794	protein coding gene	ChrX:6933754-6944848 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035508	protein coding gene	ChrX:1650525-1660933 (+)
A/J	MGP_AJ_G0035486	protein coding gene	ChrX:1625295-1635930 (+)
AKR/J	MGP_AKRJ_G0035419	protein coding gene	ChrX:1707487-1718302 (+)
BALB/cJ	MGP_BALBcJ_G0035482	protein coding gene	ChrX:1657115-1667811 (+)
C3H/HeJ	MGP_C3HHeJ_G0035190	protein coding gene	ChrX:1688174-1711166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036006	protein coding gene	ChrX:1724217-1735143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032881	protein coding gene	ChrX:1191162-1201648 (+)
CAST/EiJ	MGP_CASTEiJ_G0034490	protein coding gene	ChrX:1580969-1592566 (+)
CBA/J	MGP_CBAJ_G0035160	protein coding gene	ChrX:1819570-1833025 (+)
DBA/2J	MGP_DBA2J_G0035317	protein coding gene	ChrX:1665574-1676132 (+)
FVB/NJ	MGP_FVBNJ_G0035264	protein coding gene	ChrX:1624116-1634134 (+)
LP/J	MGP_LPJ_G0035394	protein coding gene	ChrX:1660463-1671975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035303	protein coding gene	ChrX:1792657-1803124 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036024	protein coding gene	ChrX:1652571-1662810 (+)
PWK/PhJ	MGP_PWKPhJ_G0034192	protein coding gene	ChrX:1578237-1589576 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034029	protein coding gene	ChrX:1588503-1604697 (+)
WSB/EiJ	MGP_WSBEiJ_G0034613	protein coding gene	ChrX:1651746-1664068 (+)

Human Ortholog

AKAP4, A-kinase anchoring protein 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKAP4, A-kinase anchoring protein 4
Synonyms

AKAP-4, AKAP82, AKAP 82, CT99, FSC1, hAKAP82, HI, p82, PRKA4
Links

HGNC:374

NCBI Gene ID: 8852

neXtProt AC: NX_Q5JQC9

UniProt: Q5JQC9
Chr Location

Xp11.22; chrX:50190777-50201007 (-) GRCh38

MGI Vertebrate Homology

Akap4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AKAP4
Gene Tree

Akap4

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this locus results in male infertility due to impaired sperm motility. Heterozygous mutant females show no reproductive defects.

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All GO Annotations

35
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

23
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS40838.1, CCDS40839.1

Ensembl

ENSMUSG00000050089 (Evidence)
NCBI Gene

11643

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050089	Ensembl Gene Model \| MGI Sequence Detail	11091	C57BL/6J	± kb
transcript	ENSMUST00000057101	Ensembl \| MGI Sequence Detail	2851	Not Applicable
polypeptide	ENSMUSP00000050962	Ensembl \| MGI Sequence Detail	849	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003891 A-kinase anchor protein 4

(term hierarchy)
InterPro Domains

IPR020799 A-kinase anchor 110kDa

IPR018292 A-kinase anchor 110kDa, C-terminal

IPR018459 RII binding domain

IPR008382 SPHK1-interactor/A-kinase anchor 110kDa

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All nucleic 29

Genomic 5

cDNA 23

Primer pair 1

Microarray probesets 6

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MGD-MRK-19702

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 4
Earliest

J:20326 Carrera A, et al., The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994 Sep;165(1):272-84
Latest

J:305434 Scovell JM, et al., PRSS50 is a testis protease responsible for proper sperm tail formation and function. Development. 2021 Apr 15;148(8):dev197558

TSS for Akap4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160366	ChrX:6933735-6933754 (+)	-13 bp
Tssr160367	ChrX:6933755-6933773 (+)	6 bp
Tssr160368	ChrX:6934447-6934458 (+)	695 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23