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Rab18
Gene Detail
Symbol

Name
ID
Rab18
RAB18, member RAS oncogene family
MGI:102790
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:6765205-6790231 bp, + strand
From Ensembl annotation of GRCm38

  25027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40765  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB18
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab18

Human
homologs
RAB18, RAB18, member RAS oncogene family
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 22931
neXtProt AC: NX_Q9NP72

Human Synonyms: RAB18LI1, WARBM3

Human Chr (Location): 10p12.1; chr10:27504174-27542237 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RAB18

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(24) Targeted(1)
Incidental mutations (data from CvDC )
 
Homozygous null mice show abnormal eye development, develop nuclear cataracts, atonic pupils, progressive limb weakness, disruption of neuronal cytoskeleton, and accumulation of neurofilament and microtubule proteins in synaptic terminals.
 
Human Diseases Modeled in Mice Using Rab18 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Rab18 interacts with 273 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (42)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
cDNA source data(191)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab18 ; ZFIN rab18a, rab18b    NEW 
Molecular
reagents
All nucleic(191) cDNA(191)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000073639 (Evidence)
Entrez Gene 19330 (Evidence)
UniGene 132802
DFCI TC1573570, TC1611585
DoTS DT.101283792, DT.534966, DT.110784408
NIA Mouse Gene Index U018378
Consensus CDS Project CCDS29044.1
International Mouse Phenotyping Consortium Status Rab18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073639 Ensembl Gene Model | MGI Sequence Detail 25027 C57BL/6J ±  kb
transcript ENSMUST00000097680 Ensembl | MGI Sequence Detail 2257 Not Applicable 
polypeptide ENSMUSP00000095285 Ensembl | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR025662 Sigma-54 interaction domain, ATP-binding site 1
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013589 ras-related protein Rab-18
References
(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:211808 Carpanini SM, et al., A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton. Dis Model Mech. 2014 Jun;7(6):711-22
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19698, MGI:2147186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory