About   Help   FAQ
Fen1
Gene Detail
 Symbol
Name
ID
Fen1
flap structure specific endonuclease 1
MGI:102779
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:10199132-10204169 bp, - strand
From VEGA annotation of GRCm38

  5038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fen1

Human
homologs
Human Homolog FEN1, flap structure-specific endonuclease 1
NCBI Gene ID 2237
neXtProt AC  NX_P39748
Human Synonyms  FEN-1, MF1, RAD2
Human Chr (Location)  11q12; chr11:61792637-61797244 (+)  GRCh38
Alleles
and
phenotypes
All alleles(48) : Gene trapped(41) Targeted(7)
 
Homozygous null mutants do not form an inner cell mass, lack DNA synthesis in blastocyst giant cells and die by embryonic day 9.5. Embryonic day 3.5 blastocysts are hypersensitive to irradiation. Heterozygotes show enhanced adenocarcinoma susceptibility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to DNA damage stimulus, DNA catabolic process, endonucleolytic, ...
Component membrane, mitochondrion, ...
Function 5'-3' exonuclease activity, 5'-flap endonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (15)   
Theiler Stages: 10, 18, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 3
RT-PCR 12
cDNA source data(143)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(145) cDNA(144) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034053 (Evidence)
Ensembl Gene ModelENSMUSG00000024742 (Evidence)
Entrez Gene14156 (Evidence)
UniGene2952
DFCITC1572233, TC1605862, TC1698812
DoTSDT.101355651, DT.101390712, DT.101736835, DT.110883897, DT.491409, DT.97383192
EC3.1.-.-
Consensus CDS ProjectCCDS29573.1
International Mouse Knockout Project StatusFen1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034053 VEGA Gene Model | MGI Sequence Detail 5038 C57BL/6J ±  kb
transcript OTTMUST00000086005 VEGA | MGI Sequence Detail 2373 Not Applicable 
polypeptide OTTMUSP00000046515 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(14) UniProt(6)
Polymorphisms SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020045 5'-3' exonuclease, C-terminal domain
InterPro IPR023426 Flap structure-specific endonuclease
InterPro IPR008918 Helix-hairpin-helix motif, class 2
InterPro IPR019974 XPG conserved site
InterPro IPR006086 XPG-I domain
InterPro IPR006085 XPG N-terminal
Protein Ontology PR:000007457 flap endonuclease 1
References (Earliest) J:25230 Harrington JJ, et al., Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev. 1994 Jun 1;8(11):1344-55
(Latest) J:200226 Xu M, et al., Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase beta and alternate flap cleavage by flap endonuclease 1. Nucleic Acids Res. 2013 Feb 1;41(3):1684-97
All references(50)
Other
accession IDs
MGD-MRK-19687, MGI:2147740

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory