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Fen1
Gene Detail
Symbol

Name
ID
Fen1
flap structure specific endonuclease 1
MGI:102779
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:10199132-10204169 bp, - strand
From VEGA annotation of GRCm38

  5038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FEN1
Gene Tree: Fen1

Human
homologs
FEN1, flap structure-specific endonuclease 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2237
neXtProt AC: NX_P39748

Human Synonyms: FEN-1, MF1, RAD2

Human Chr (Location): 11q12; chr11:61792637-61797244 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(41) Targeted(8)
 
Homozygous null mutants do not form an inner cell mass, lack DNA synthesis in blastocyst giant cells and die by embryonic day 9.5. Embryonic day 3.5 blastocysts are hypersensitive to irradiation. Heterozygotes show enhanced adenocarcinoma susceptibility.
 
Interactions
Fen1 interacts with 108 markers (Mir1b, Mir7-1, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular response to DNA damage stimulus, DNA metabolic process, ...
Component membrane, mitochondrion, ...
Function 5'-3' exonuclease activity, 5'-flap endonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (15)    Tissues (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 12
cDNA source data(143)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fen1 ; ZFIN fen1    NEW 
Molecular
reagents
All nucleic(145) cDNA(144) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034053 (Evidence)
Ensembl Gene Model ENSMUSG00000024742 (Evidence)
Entrez Gene 14156 (Evidence)
UniGene 2952
DFCI TC1698812, TC1605862, TC1572233
DoTS DT.110883897, DT.101736835, DT.101390712, DT.101355651, DT.491409, DT.97383192
EC 3.1.-.-
Consensus CDS Project CCDS29573.1
International Mouse Phenotyping Consortium Status Fen1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034053 VEGA Gene Model | MGI Sequence Detail 5038 C57BL/6J ±  kb
transcript OTTMUST00000086005 VEGA | MGI Sequence Detail 2373 Not Applicable 
polypeptide OTTMUSP00000046515 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(14) UniProt(6)
Polymorphisms
SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020045 5'-3' exonuclease, C-terminal domain
InterPro IPR023426 Flap structure-specific endonuclease
InterPro IPR008918 Helix-hairpin-helix motif, class 2
InterPro IPR019974 XPG conserved site
InterPro IPR006086 XPG-I domain
InterPro IPR006085 XPG N-terminal
InterPro IPR006084 XPG/Rad2 endonuclease
Protein Ontology PR:000007457 flap endonuclease 1
References
(Earliest) J:25230 Harrington JJ, et al., Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev. 1994 Jun 1;8(11):1344-55
(Latest) J:218627 Chung L, et al., The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. Oncogene. 2015 Feb 12;34(7):902-11
All references(52)
Other
accession IDs
MGD-MRK-19687, MGI:2147740

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory