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Ap1m1
Gene Detail
 Symbol
Name
ID
Ap1m1
adaptor-related protein complex AP-1, mu subunit 1
MGI:102776
Synonyms Adtm1A, AP47, Cltnm, [m]1A, mu1A
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:72240018-72257385 bp, + strand
From VEGA annotation of GRCm38

  17368 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4017  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex, mu subunit
Gene Tree: Ap1m1

Human
homologs
Human Homolog AP1M1, adaptor-related protein complex 1, mu 1 subunit
NCBI Gene ID 8907
neXtProt AC  NX_Q9BXS5
Human Synonyms  AP47, CLAPM2, CLTNM, MU-1A
Human Chr (Location)  19p13.12; chr19:16197854-16235345 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality around E13.5. Homozygous embryos display hemorrhage of the ventricles and spinal canal.
 
Interactions
Ap1m1 interacts with 85 markers (Mir7-1, Mir15a, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process endosome to melanosome transport, intracellular protein transport, ...
Component cell, clathrin adaptor complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(155) cDNA(155)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022231 (Evidence)
Ensembl Gene ModelENSMUSG00000003033 (Evidence)
Entrez Gene11767 (Evidence)
UniGene290086
DFCITC1573021, TC1631351
DoTSDT.103576088, DT.110882875, DT.535269, DT.91421308, DT.94158065
NIA Mouse Gene IndexU009486
PDB4EMZ, 4HMY, 4P6Z, 1W63, 4EN2
Consensus CDS ProjectCCDS22411.1
International Mouse Knockout Project StatusAp1m1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022231 VEGA Gene Model | MGI Sequence Detail 17368 C57BL/6J ±  kb
transcript OTTMUST00000052877 VEGA | MGI Sequence Detail 2084 Not Applicable 
polypeptide OTTMUSP00000025123 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(172 from dbSNP Build 137)    SNPs within 2kb including multiple locations(174)
Protein-related
information
ResourceIDDescription
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR001392 Clathrin adaptor, mu subunit
InterPro IPR018240 Clathrin adaptor, mu subunit, conserved site
InterPro IPR008968 Clathrin adaptor, mu subunit, C-terminal
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004094 AP-1 complex subunit mu-1
References (Earliest) J:2826 Nakayama Y, et al., The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991 Dec 5;202(2):569-74
(Latest) J:201285 Ren X, et al., Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell. 2013 Feb 14;152(4):755-67
All references(34)
Other
accession IDs
MGD-MRK-19683, MGI:2142408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory