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Ap1m1 Gene Detail
Summary
  • Symbol
    Ap1m1
  • Name
    adaptor-related protein complex AP-1, mu subunit 1
  • Synonyms
    Adtm1A, AP47, Cltnm, [m]1A, mu1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:102776
    NCBI Gene: 11767
  • Gene Overview
    MyGene.info: AP1M1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72240052-72257385 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102776
protein coding gene Chr8:72240018-72257385 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033778
protein coding gene Chr8:72713041-72730245 (+)
A/J MGP_AJ_G0033760
protein coding gene Chr8:69776031-69793199 (+)
AKR/J MGP_AKRJ_G0033687
protein coding gene Chr8:71840162-71856580 (+)
BALB/cJ MGP_BALBcJ_G0033754
protein coding gene Chr8:69903370-69921705 (+)
C3H/HeJ MGP_C3HHeJ_G0033463
protein coding gene Chr8:72462584-72479853 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034274
protein coding gene Chr8:75463606-75487619 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031215
protein coding gene Chr8:64291984-64308972 (+)
CAST/EiJ MGP_CASTEiJ_G0032792
protein coding gene Chr8:71813448-71831786 (+)
CBA/J MGP_CBAJ_G0033442
protein coding gene Chr8:78155290-78180434 (+)
DBA/2J MGP_DBA2J_G0033596
protein coding gene Chr8:69514959-69532410 (+)
FVB/NJ MGP_FVBNJ_G0033541
protein coding gene Chr8:68588567-68605994 (+)
LP/J MGP_LPJ_G0033685
protein coding gene Chr8:72806283-72824092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033585
protein coding gene Chr8:80666210-80684703 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034291
protein coding gene Chr8:71888408-71905781 (+)
PWK/PhJ MGP_PWKPhJ_G0032498
protein coding gene Chr8:68774758-68792115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032335
protein coding gene Chr8:70829396-70848116 (+)
WSB/EiJ MGP_WSBEiJ_G0032907
protein coding gene Chr8:72204190-72222812 (+)



Homology
more
  • Human Ortholog
    AP1M1, adaptor related protein complex 1 subunit mu 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AP1M1, adaptor related protein complex 1 subunit mu 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AP47, CLAPM2, CLTNM, MU-1A
  • Links
    NCBI Gene ID: 8907
    neXtProt AC: NX_Q9BXS5
    UniProt: Q9BXS5

  • Chr Location
    19p13.11; chr19:16197854-16235345 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E13.5. Homozygous embryos display hemorrhage of the ventricles and spinal canal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11767 NCBI Gene Model | MGI Sequence Detail 17334 C57BL/6J ±  kb
transcript NM_007456 RefSeq | MGI Sequence Detail 2085 C57BL/6  
polypeptide P35585 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 156
    cDNA 156

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19683, MGI:2142408
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:2826 Nakayama Y, et al., The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991 Dec 5;202(2):569-74
  • Latest
    J:242510 Dib K, et al., The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit mu1A via a novel basic binding motif. J Biol Chem. 2017 Apr 21;292(16):6703-6714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory