Aimp1
Gene Detail

Symbol Name ID

Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 MGI:102774

Synonyms

9830137A06Rik, AIMP1/p43, Emap2, EMAPII, Scye1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

61.48 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:132660498-132683879 bp, - strand From NCBI annotation of GRCm38   23382 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: endothelial monocyte-activating polypeptide II precursor (pro-EMAP II)
Gene Tree: Aimp1

Human homologs

Human Homolog		AIMP1, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
NCBI Gene ID		9255
neXtProt AC		NX_Q12904
Human Synonyms		EMAP2, EMAPII, HLD3, p43, SCYE1
Human Chr (Location)		4q24; chr4:107236767-107270382 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AIMP1

Alleles and phenotypes

All alleles(35) : Targeted(2) Gene trapped(33)
 

Mice homozygous for a gene trap allele display delayed wound healing and decreased inflammatory response after wounding.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	angiogenesis, apoptotic process, ...
Component	aminoacyl-tRNA synthetase multienzyme complex, cytoplasm, ...
Function	cytokine activity, protein homodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (169)    Tissues (114)    Images (21)
Theiler Stages: 13, 14, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	115
Western blot	46

cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(125) cDNA(124) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000028029 (Evidence)
Entrez Gene	13722 (Evidence)
UniGene	235137
DFCI	TC1574681, TC1598440
DoTS	DT.101403857, DT.495538, DT.97337805
NIA Mouse Gene Index	U024664
Consensus CDS Project	CCDS38642.1
International Mouse Knockout Project Status	Aimp1

Sequences

Length	Strain/Species
genomic	13722	NCBI Gene Model | MGI Sequence Detail	23382	C57BL/6J
transcript	NM_007926	RefSeq | MGI Sequence Detail	1122	C57BL/6
polypeptide	P31230	UniProt | EBI | MGI Sequence Detail	310	Not Applicable

All sequences(27) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(114 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR002547	tRNA-binding domain
Protein Ontology	PR:000014547	multisynthetase complex auxiliary component p43

Graphical View of Protein Domain Structure

References

(Earliest) J:20657 Kao J, et al., Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem. 1994 Oct 7;269(40):25106-19
(Latest) J:184868 Hong HJ, et al., AIMP1 deficiency enhances airway hyperreactivity in mice via increased T(H)2 immune responses. Clin Immunol. 2012 Jun;143(3):256-65
All references(48)

Other accession IDs

MGD-MRK-19681, MGI:2445109