About   Help   FAQ
Aimp1
Gene Detail
Symbol

Name
ID
Aimp1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
MGI:102774
Synonyms
9830137A06Rik, AIMP1/p43, Emap2, EMAPII, Scye1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
61.48 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:132660498-132683879 bp, - strand
From NCBI annotation of GRCm38

  23382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AIMP1
Protein SuperFamily: endothelial monocyte-activating polypeptide II precursor (pro-EMAP II)
Gene Tree: Aimp1

Human
homologs
AIMP1, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9255
neXtProt AC: NX_Q12904

Human Synonyms: EMAP2, EMAPII, HLD3, p43, SCYE1

Human Chr (Location): 4q24; chr4:106315610-106349225 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AIMP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(33) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele display delayed wound healing and decreased inflammatory response after wounding.
 
Interactions
Aimp1 interacts with 35 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process angiogenesis, apoptotic process, ...
Component aminoacyl-tRNA synthetase multienzyme complex, cell surface, ...
Function cytokine activity, GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (169)    Tissues (117)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 115
Western blot 46
cDNA source data(124)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aimp1    NEW 
Molecular
reagents
All nucleic(125) cDNA(124) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000028029 (Evidence)
Entrez Gene 13722 (Evidence)
UniGene 235137
DFCI TC1598440, TC1574681
DoTS DT.97337805, DT.495538, DT.101403857
NIA Mouse Gene Index U024664
Consensus CDS Project CCDS38642.1
International Mouse Phenotyping Consortium Status Aimp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13722 NCBI Gene Model | MGI Sequence Detail 23382 C57BL/6J ±  kb
transcript NM_007926 RefSeq | MGI Sequence Detail 1122 C57BL/6 
polypeptide P31230 UniProt | EBI | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR002547 tRNA-binding domain
Protein Ontology PR:000014547 multisynthetase complex auxiliary component p43
Graphical View of Protein Domain Structure
References
(Earliest) J:20657 Kao J, et al., Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem. 1994 Oct 7;269(40):25106-19
(Latest) J:184868 Hong HJ, et al., AIMP1 deficiency enhances airway hyperreactivity in mice via increased T(H)2 immune responses. Clin Immunol. 2012 Jun;143(3):256-65
All references(48)
Other
accession IDs
MGD-MRK-19681, MGI:2445109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory