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Gbp2 Gene Detail
Summary
  • Symbol
    Gbp2
  • Name
    guanylate binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102772
    NCBI Gene: 14469
  • Gene Overview
    MyGene.info: GBP2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142620663-142638008 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102772
protein coding gene Chr3:142620602-142638008 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027945
protein coding gene Chr3:145835008-145854894 (+)
A/J MGP_AJ_G0027902
protein coding gene Chr3:140661063-140675686 (+)
AKR/J MGP_AKRJ_G0027868
protein coding gene Chr3:144411456-144428312 (+)
BALB/cJ MGP_BALBcJ_G0027914
protein coding gene Chr3:140460824-140489325 (+)
C3H/HeJ MGP_C3HHeJ_G0027644
protein coding gene Chr3:144726392-144746165 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028358
protein coding gene Chr3:150889757-150908051 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025696
protein coding gene Chr3:135889009-135907579 (+)
CAST/EiJ MGP_CASTEiJ_G0027100
protein coding gene Chr3:144699563-144719064 (+)
CBA/J MGP_CBAJ_G0027621
protein coding gene Chr3:156165982-156186369 (+)
DBA/2J MGP_DBA2J_G0027760
protein coding gene Chr3:139826462-139844180 (+)
FVB/NJ MGP_FVBNJ_G0027727
protein coding gene Chr3:137247437-137265893 (+)
LP/J MGP_LPJ_G0027870
protein coding gene Chr3:147257159-147274823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027759
protein coding gene Chr3:164452243-164471067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028416
protein coding gene Chr3:144037035-144054446 (+)
PWK/PhJ MGP_PWKPhJ_G0026824
protein coding gene Chr3:139595500-139671684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026651
protein coding gene Chr3:142126148-142188169 (+)
WSB/EiJ MGP_WSBEiJ_G0027179
protein coding gene Chr3:144916115-144932092 (+)



Homology
more
  • Human Ortholog
    GBP2, guanylate binding protein 2
  • Vertebrate Orthologs
    15
  • Human Ortholog
    GBP2, guanylate binding protein 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2634
    neXtProt AC: NX_P32456
    UniProt: P32456

  • Chr Location
    1p22.2; chr1:89106132-89126159 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to increased susceptibility to chronic Toxoplasma gondii infection, characterized by an increased parasite burden in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14469 NCBI Gene Model | MGI Sequence Detail 17346 C57BL/6J ±  kb
transcript NM_010260 RefSeq | MGI Sequence Detail 2471 C57BL/6  
polypeptide Q9Z0E6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein/Atlastin, C-terminal
    IPR037684 Guanylate-binding protein, C-terminal
    IPR036543 Guanylate-binding protein, C-terminal domain superfamily
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 124
    Genomic 2
    cDNA 119
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19679
References
more
  • Summaries
    All 58
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:37849 Cheng YS, et al., Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol. 1991 Sep;11(9):4717-25
  • Latest
    J:258482 Santos JC, et al., LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018 Mar 15;37(6)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory