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Mfge8
Gene Detail
 Symbol
Name
ID
Mfge8
milk fat globule-EGF factor 8 protein
MGI:102768
Synonyms EGF/factor VIII, lactadherin, MFG-E8, Mfgm, SED1
Feature Type protein coding gene
Genetic Map
Chromosome 7
44.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79133769-79149060 bp, - strand
From Ensembl annotation of GRCm38

  15292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: lactadherin-like protein
Gene Tree: Mfge8

Human
homologs
Human Homolog MFGE8, milk fat globule-EGF factor 8 protein
NCBI Gene ID 4240
neXtProt AC  NX_Q08431
Human Synonyms  BA46, EDIL1, HMFG, hP47, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10
Human Chr (Location)  15q25; chr15:88898683-88913454 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display reduced male fertility associated with impaired zona pellucida binding. Fertility is unaffected in female mutant mice. Splenomegaly occurs with age and defects occur in phagocytosis.
 
Interactions
Mfge8 interacts with 79 markers (Mir1a-1, Mir1a-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process angiogenesis, cell adhesion, ...
Component external side of plasma membrane, extracellular matrix, ...
Function integrin binding, phosphatidylethanolamine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (189)    Tissues (53)    Images (60)
Theiler Stages: 16, 17, 19, 20, 21, 22, 23
Assay TypeResults
Immunohistochemistry 9
RNA in situ 166
Western blot 7
RT-PCR 7
cDNA source data(1284)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1287) cDNA(1284) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030605 (Evidence)
Entrez Gene17304 (Evidence)
UniGene1451
DFCITC1573688, TC1574256, TC1641440
DoTSDT.101182379, DT.101182383, DT.101182389, DT.101182390, DT.101182392, DT.87072661, DT.94282064, DT.94282121, DT.97371896
NIA Mouse Gene IndexU028740
PDB2L9L
Consensus CDS ProjectCCDS21379.1, CCDS39989.1
International Mouse Knockout Project StatusMfge8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030605 Ensembl Gene Model | MGI Sequence Detail 15292 C57BL/6J ±  kb
transcript ENSMUST00000032825 Ensembl | MGI Sequence Detail 2125 Not Applicable 
polypeptide ENSMUSP00000032825 Ensembl | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR027060 Lactadherin
Protein Ontology PR:000010367 lactadherin
References (Earliest) J:10818 Stubbs JD, et al., cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8417-21
(Latest) J:206863 Khalifeh-Soltani A, et al., Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014 Feb;20(2):175-83
All references(95)
Other
accession IDs
MGD-MRK-19675, MGI:2141815, MGI:2141915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory