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Star Gene Detail
Summary
  • Symbol
    Star
  • Name
    steroidogenic acute regulatory protein
  • Synonyms
    D8Ertd419e
  • Feature Type
    protein coding gene
  • IDs
    MGI:102760
    NCBI Gene: 20845
Location & Maps
more
  • Sequence Map
    Chr8:25808474-25814723 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6250 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    STARD1
  • Links
    NCBI Gene ID: 6770
    neXtProt AC: NX_P49675

  • Chr Location
    8p11.2; chr8:38142700-38151265 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 297
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STAR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Star mouse models; 1 with human STAR associations

Human Disease Mouse Models
       Lipoid Congenital Adrenal Hyperplasia; LCAH   OMIM: 201710 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031856 VEGA Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript OTTMUST00000078990 VEGA | MGI Sequence Detail 2787 Not Applicable  
polypeptide OTTMUSP00000042085 VEGA | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015715 steroidogenic acute regulatory protein, mitochondrial
  • InterPro Domains
    IPR002913 START domain
    IPR023393 START-like domain
    IPR029866 Steroidogenic acute regulatory protein
    IPR000799 Steroidogenic acute regulatory protein-like
Molecular
Reagents
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  • All nucleic 51
    Genomic 1
    cDNA 46
    Primer pair 4

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-19665, MGI:1196454, MGI:2142741
References
more
  • Summaries
    All 83
    Developmental Gene Expression 32
    Diseases 3
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
  • Latest
    J:228826 Cisternas CD, et al., Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain. Mol Cell Endocrinol. 2015 Oct 15;414:99-110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory