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Star
Gene Detail
Symbol

Name
ID
Star
steroidogenic acute regulatory protein
MGI:102760
Synonyms
D8Ertd419e
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:25808474-25814723 bp, + strand
From VEGA annotation of GRCm38

  6250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Star

Human
homologs
Human Homolog STAR, steroidogenic acute regulatory protein
NCBI Gene ID 6770
neXtProt AC  NX_P49675
Human Synonyms  STARD1
Human Chr (Location)  8p11.2; chr8:38142700-38151265 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human STAR
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.
 
Human Diseases Modeled Using Mouse Star (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Star interacts with 253 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process bile acid biosynthetic process, cellular lipid metabolic process, ...
Component cytosol, mitochondrial crista, ...
Function lipid binding
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (70)    Tissues (28)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 50
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(46) Primer pair(4)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000031856 (Evidence)
Ensembl Gene ModelENSMUSG00000031574 (Evidence)
Entrez Gene20845 (Evidence)
UniGene293314
DFCITC1580645, TC1586512, TC1662452
DoTSDT.101381662, DT.527443
NIA Mouse Gene IndexU009204
Consensus CDS ProjectCCDS22203.1
International Mouse Knockout Project StatusStar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031856 VEGA Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript OTTMUST00000078990 VEGA | MGI Sequence Detail 2787 Not Applicable 
polypeptide OTTMUSP00000042085 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
InterPro IPR000799 Steroidogenic acute regulatory protein
Protein Ontology PR:000015715 steroidogenic acute regulatory protein, mitochondrial
References
(Earliest) J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
(Latest) J:197548 Pihlajoki M, et al., Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67
All references(76)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-19665, MGI:1196454, MGI:2142741

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory