About   Help   FAQ
Star Gene Detail
Summary
  • Symbol
    Star
  • Name
    steroidogenic acute regulatory protein
  • Synonyms
    D8Ertd419e
  • Feature Type
    protein coding gene
  • IDs
    MGI:102760
    NCBI Gene: 20845
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25808513-25815982 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102760
protein coding gene Chr8:25806555-25815982 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033489
protein coding gene Chr8:23880304-23886547 (+)
A/J MGP_AJ_G0033469
protein coding gene Chr8:23013326-23019589 (+)
AKR/J MGP_AKRJ_G0033394
protein coding gene Chr8:23774899-23782416 (+)
BALB/cJ MGP_BALBcJ_G0033465
protein coding gene Chr8:23159479-23166064 (+)
C3H/HeJ MGP_C3HHeJ_G0033179
protein coding gene Chr8:23984273-23990567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033981
protein coding gene Chr8:24846689-24852858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030931
protein coding gene Chr8:20278691-20284723 (+)
CAST/EiJ MGP_CASTEiJ_G0032505
protein coding gene Chr8:23434365-23440545 (+)
CBA/J MGP_CBAJ_G0033154
protein coding gene Chr8:25814498-25823437 (+)
DBA/2J MGP_DBA2J_G0033309
protein coding gene Chr8:22983349-22989690 (+)
FVB/NJ MGP_FVBNJ_G0033253
protein coding gene Chr8:22789600-22795891 (+)
LP/J MGP_LPJ_G0033398
protein coding gene Chr8:23858155-23864326 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033296
protein coding gene Chr8:25273490-25279711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034000
protein coding gene Chr8:23707806-23714018 (+)
PWK/PhJ MGP_PWKPhJ_G0032216
protein coding gene Chr8:22624480-22630689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032050
protein coding gene Chr8:23083755-23090002 (+)
WSB/EiJ MGP_WSBEiJ_G0032621
protein coding gene Chr8:23928307-23935817 (+)



Homology
more
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAR, steroidogenic acute regulatory protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    STARD1
  • Links
    NCBI Gene ID: 6770
    neXtProt AC: NX_P49675
    UniProt: P49675

  • Chr Location
    8p11.23; chr8:38141747-38151265 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 297
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STAR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Star mouse models; 1 with human STAR associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20845 NCBI Gene Model | MGI Sequence Detail 7470 C57BL/6J ±  kb
    transcript NM_011485 RefSeq | MGI Sequence Detail 4046 C57BL/6  
    polypeptide P51557 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 47
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-19665, MGI:1196454, MGI:2142741
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 39
      Diseases 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
    • Latest
      J:256730 Shawki HH, et al., MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. PLoS One. 2018;13(1):e0190800

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory