Star
Gene Detail

Symbol Name ID

Star steroidogenic acute regulatory protein MGI:102760

Synonyms

D8Ertd419e

Feature Type

protein coding gene

Genetic Map

Chromosome 8

14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:25808474-25814723 bp, + strand From VEGA annotation of GRCm38   6250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Star

Human homologs

Human Homolog		STAR, steroidogenic acute regulatory protein
NCBI Gene ID		6770
neXtProt AC		NX_P49675
Human Synonyms		STARD1
Human Chr (Location)		8p11.2; chr8:38000218-38008600 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STAR

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.

 
Human Diseases Modeled Using Mouse Star (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	bile acid biosynthetic process, cellular lipid metabolic process, ...
Component	cytosol, mitochondrial crista, ...
Function	cholesterol binding, cholesterol transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (70)    Tissues (28)    Images (17)
Theiler Stages: 13, 15, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	20
RT-PCR	50

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(1) cDNA(46) Primer pair(4)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000031856 (Evidence)
Ensembl Gene Model	ENSMUSG00000031574 (Evidence)
Entrez Gene	20845 (Evidence)
UniGene	293314
DFCI	TC1580645, TC1586512, TC1662452
DoTS	DT.101381662, DT.527443
NIA Mouse Gene Index	U009204
Consensus CDS Project	CCDS22203.1
International Mouse Knockout Project Status	Star

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031856	VEGA Gene Model | MGI Sequence Detail	6250	C57BL/6J
transcript	OTTMUST00000078990	VEGA | MGI Sequence Detail	2787	Not Applicable
polypeptide	OTTMUSP00000042085	VEGA | MGI Sequence Detail	284	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002913	Lipid-binding START
InterPro	IPR023393	START-like domain
InterPro	IPR000799	Steroidogenic acute regulatory protein
Protein Ontology	PR:000015715	steroidogenic acute regulatory protein, mitochondrial

References

(Earliest) J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(74)

Other accession IDs

MGD-MRK-19665, MGI:1196454, MGI:2142741