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Star
Gene Detail
Symbol

Name
ID
Star
steroidogenic acute regulatory protein
MGI:102760
Synonyms
D8Ertd419e
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:25808474-25814723 bp, + strand
From VEGA annotation of GRCm38

  6250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STAR
Gene Tree: Star

Human
homologs
STAR, steroidogenic acute regulatory protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6770
neXtProt AC: NX_P49675

Human Synonyms: STARD1

Human Chr (Location): 8p11.2; chr8:38142700-38151265 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human STAR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mice fail to thrive and die during the postnatal period due to adrenocortical insufficiency. Mice exhibit male pseudohermaprhoditism and show a progressive accumulation of lipids within steroidogenic cells of the adrenal glands and gonads.
 
Human Diseases Modeled in Mice Using Star (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Star interacts with 252 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process bile acid biosynthetic process, cellular lipid metabolic process, ...
Component cytosol, mitochondrial crista, ...
Function cholesterol binding, cholesterol transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (70)    Tissues (34)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 50
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492318 ; ZFIN star    NEW 
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(46) Primer pair(4)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000031856 (Evidence)
Ensembl Gene Model ENSMUSG00000031574 (Evidence)
Entrez Gene 20845 (Evidence)
UniGene 293314
DFCI TC1662452, TC1586512, TC1580645
DoTS DT.527443, DT.101381662
NIA Mouse Gene Index U009204
Consensus CDS Project CCDS22203.1
International Mouse Phenotyping Consortium Status Star
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031856 VEGA Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
transcript OTTMUST00000078990 VEGA | MGI Sequence Detail 2787 Not Applicable 
polypeptide OTTMUSP00000042085 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
InterPro IPR000799 Steroidogenic acute regulatory protein
Protein Ontology PR:000015715 steroidogenic acute regulatory protein, mitochondrial
References
(Earliest) J:21385 Clark BJ, et al., The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994 Nov 11;269(45):28314-22
(Latest) J:217603 Vanhoutteghem A, et al., The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014 Nov;141(22):4298-310
All references(75)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-19665, MGI:1196454, MGI:2142741

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory