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Prss2 Gene Detail
Summary
  • Symbol
    Prss2
  • Name
    protease, serine 2
  • Synonyms
    Ta, Tesp4, Try2, TRY8, TRYP
  • Feature Type
    protein coding gene
  • IDs
    MGI:102759
    NCBI Gene: 22072
  • Gene Overview
    MyGene.info: PRSS2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41521787-41525079 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102759
protein coding gene Chr6:41521776-41525079 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030629
protein coding gene Chr6:40025959-40029251 (+)
A/J MGP_AJ_G0030602
protein coding gene Chr6:38283348-38286640 (+)
AKR/J MGP_AKRJ_G0030527
protein coding gene Chr6:39521675-39524967 (+)
BALB/cJ MGP_BALBcJ_G0030612
protein coding gene Chr6:38491862-38495154 (+)
C3H/HeJ MGP_C3HHeJ_G0030325
protein coding gene Chr6:39552594-39555886 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031066
protein coding gene Chr6:41037990-41041282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028273
protein coding gene Chr6:36062733-36065984 (+)
CAST/EiJ MGP_CASTEiJ_G0029729
protein coding gene Chr6:39356048-39359320 (+)
CBA/J MGP_CBAJ_G0030301
protein coding gene Chr6:42745631-42748923 (+)
DBA/2J MGP_DBA2J_G0030445
protein coding gene Chr6:38118212-38121504 (+)
FVB/NJ MGP_FVBNJ_G0030401
protein coding gene Chr6:37839608-37842901 (+)
LP/J MGP_LPJ_G0030533
protein coding gene Chr6:40038449-40041741 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030435
protein coding gene Chr6:44980477-44983769 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031096
protein coding gene Chr6:39498640-39501932 (+)
PWK/PhJ MGP_PWKPhJ_G0029441
protein coding gene Chr6:37733070-37736481 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029278
protein coding gene Chr6:39112646-39115990 (+)
WSB/EiJ MGP_WSBEiJ_G0029805
protein coding gene Chr6:39408695-39411983 (+)



Homology
more
  • Human Ortholog
    PRSS2, serine protease 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRSS2, serine protease 2
    Orthology source: HomoloGene
  • Synonyms
    TRY2, TRY8, TRYP2
  • Links
    NCBI Gene ID: 5645
    neXtProt AC: NX_P07478
    UniProt: P07478

  • Chr Location
    7q34; chr7:142770943-142774564 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRSS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057163 Ensembl Gene Model | MGI Sequence Detail 3293 C57BL/6J ±  kb
transcript ENSMUST00000070380 Ensembl | MGI Sequence Detail 815 Not Applicable  
polypeptide ENSMUSP00000065393 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 573
    Genomic 1
    cDNA 572

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19664
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory