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Prss2
Gene Detail
 Symbol
Name
ID
Prss2
protease, serine 2
MGI:102759
Synonyms Ta, Tesp4, Try2, TRY8, TRYP
Feature Type protein coding gene
Genetic Map
Chromosome 6
19.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:41521787-41525079 bp, + strand
From VEGA annotation of GRCm38

  3293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:122141  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Prss2

Human
homologs
Human Homolog PRSS2, protease, serine, 2 (trypsin 2)
NCBI Gene ID 5645
neXtProt AC  NX_P07478
Human Synonyms  TRY2, TRY8, TRYP2
Human Chr (Location)  7q34; chr7:142770976-142774560 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRSS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Interactions
Prss2 interacts with 10 markers (Mir137, Mir200b, Mir200c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process collagen catabolic process, digestion, ...
Component extracellular region, extracellular space
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(571)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(574) Genomic(1) cDNA(571) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026925 (Evidence)
Ensembl Gene ModelENSMUSG00000057163 (Evidence)
Entrez Gene22072 (Evidence)
UniGene276926
DFCITC1573999, TC1701640
NIA Mouse Gene IndexU367048
EC3.4.21.4
Consensus CDS ProjectCCDS20050.1
International Mouse Knockout Project StatusPrss2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026925 VEGA Gene Model | MGI Sequence Detail 3293 C57BL/6J ±  kb
transcript OTTMUST00000066577 VEGA | MGI Sequence Detail 815 Not Applicable 
polypeptide OTTMUSP00000033386 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000027796 trypsin-2
References (Earliest) J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-19664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory