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Prss3 Gene Detail
Summary
  • Symbol
    Prss3
  • Name
    protease, serine 3
  • Synonyms
    mesotrypsin, MTG, Tb, Try3, TRY4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102758
    NCBI Gene: 22073
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41373759-41377613 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102758
protein coding gene Chr6:41373759-41377678 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030627
protein coding gene Chr6:39947477-39951534 (-)
A/J MGP_AJ_G0030600
protein coding gene Chr6:38190436-38204649 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030610
protein coding gene Chr6:38404885-38433576 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031063
protein coding gene Chr6:40921569-40923082 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029725
protein coding gene Chr6:39260748-39264696 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0030398
protein coding gene Chr6:37758971-37764299 (-)
LP/J MGP_LPJ_G0030531
protein coding gene Chr6:39927430-39930183 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031092
protein coding gene Chr6:39344721-39350609 (+)
PWK/PhJ MGP_PWKPhJ_G0029437
protein coding gene Chr6:37563240-37564463 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029274
protein coding gene Chr6:39020262-39024257 (-)
WSB/EiJ MGP_WSBEiJ_G0029801
protein coding gene Chr6:39250177-39253911 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22073 NCBI Gene Model | MGI Sequence Detail 3855 C57BL/6J ±  kb
transcript NM_011645 RefSeq | MGI Sequence Detail 812 Not Specified  
polypeptide NP_035775 RefSeq | MGI Sequence Detail 246 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 48
    Genomic 1
    cDNA 47

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-19663
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 2
  • Earliest
    J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
  • Latest
    J:271120 Scavuzzo MA, et al., Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018 Dec 26;25(13):3811-3827.e7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory