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Try4
Gene Detail
Symbol

Name
ID
Try4
trypsin 4
MGI:102757
Synonyms
0910001B19Rik, Td
Feature Type
protein coding gene
Genetic Map
Chromosome 6
19.41 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:41302269-41305532 bp, + strand
From VEGA annotation of GRCm38

  3264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:106639  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Try4

Human
homologs
Human Homolog PRSS3, protease, serine, 3
NCBI Gene ID 5646
neXtProt AC  NX_P35030
Human Synonyms  MTG, PRSS4, T9, TRY3, TRY4
Human Chr (Location)  9p11.2; chr9:33750466-33799231 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Try4 interacts with 8 markers (Mir325, Mir452, Mir455, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process proteolysis
Component extracellular space, extracellular vesicular exosome
Function calcium ion binding, serine-type endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(441)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(443) Genomic(2) cDNA(441)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000026910 (Evidence)
Ensembl Gene ModelENSMUSG00000054106 (Evidence)
Entrez Gene22074 (Evidence)
UniGene383263
Consensus CDS ProjectCCDS20044.1
International Mouse Knockout Project StatusTry4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026910 VEGA Gene Model | MGI Sequence Detail 3264 C57BL/6J ±  kb
transcript OTTMUST00000066552 VEGA | MGI Sequence Detail 801 Not Applicable 
polypeptide OTTMUSP00000033368 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)    SNPs within 2kb including multiple locations(38)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
References
(Earliest) J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(18)
Other
accession IDs
MGD-MRK-19662, MGI:1913350

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory