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Try4 Gene Detail
Summary
  • Symbol
    Try4
  • Name
    trypsin 4
  • Synonyms
    0910001B19Rik, Td
  • Feature Type
    protein coding gene
  • IDs
    MGI:102757
    NCBI Gene: 22074
  • Gene Overview
    MyGene.info: PRSS3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41302272-41305533 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.41 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102757
protein coding gene Chr6:41302269-41305533 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030622
protein coding gene Chr6:39785866-39860115 (+)
A/J MGP_AJ_G0030597
protein coding gene Chr6:38065250-38068785 (-)
AKR/J MGP_AKRJ_G0030524
protein coding gene Chr6:39258399-39264686 (+)
BALB/cJ MGP_BALBcJ_G0030608
protein coding gene Chr6:38281473-38284443 (-)
C3H/HeJ MGP_C3HHeJ_G0030321
protein coding gene Chr6:39302842-39308576 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029722
protein coding gene Chr6:39191821-39195975 (+)
CBA/J MGP_CBAJ_G0030296
protein coding gene Chr6:42451599-42458948 (-)
DBA/2J MGP_DBA2J_G0030442
protein coding gene Chr6:37881507-37886353 (+)
FVB/NJ MGP_FVBNJ_G0030394
protein coding gene Chr6:37617357-37620621 (+)
LP/J MGP_LPJ_G0030529
protein coding gene Chr6:39802085-39804631 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030432
protein coding gene Chr6:44687485-44689839 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0029798
protein coding gene Chr6:39177173-39180441 (+)



Homology
more
  • Human Ortholog
    PRSS3, serine protease 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRSS3, serine protease 3
    Orthology source: HomoloGene
  • Synonyms
    MTG, PRSS4, T9, TRY3, TRY4
  • Links
    NCBI Gene ID: 5646
    neXtProt AC: NX_P35030
    UniProt: P35030

  • Chr Location
    9p13.3; chr9:33750466-33799231 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22074 NCBI Gene Model | MGI Sequence Detail 3262 C57BL/6J ±  kb
transcript NM_011646 RefSeq | MGI Sequence Detail 815 Not Specified  
polypeptide NP_035776 RefSeq | MGI Sequence Detail 246 Not Specified  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 443
    Genomic 2
    cDNA 441

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-19662, MGI:1913350
References
more
  • Summaries
    All 24
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory