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Guca2a Gene Detail
Summary
  • Symbol
    Guca2a
  • Name
    guanylate cyclase activator 2a (guanylin)
  • Synonyms
    Guca2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102738
    NCBI Gene: 14915
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119637732-119639465 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 55.47 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102738
protein coding gene Chr4:119637704-119639471 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028703
protein coding gene Chr4:120847600-120849450 (+)
A/J MGP_AJ_G0028663
protein coding gene Chr4:116099396-116102738 (+)
AKR/J MGP_AKRJ_G0028616
protein coding gene Chr4:118631534-118633306 (+)
BALB/cJ MGP_BALBcJ_G0028686
protein coding gene Chr4:116729616-116731605 (+)
C3H/HeJ MGP_C3HHeJ_G0028401
protein coding gene Chr4:120189644-120191422 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029127
protein coding gene Chr4:125434703-125436474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026404
protein coding gene Chr4:110194701-110196434 (+)
CAST/EiJ MGP_CASTEiJ_G0027832
protein coding gene Chr4:117511393-117513157 (+)
CBA/J MGP_CBAJ_G0028368
protein coding gene Chr4:128834419-128836807 (+)
DBA/2J MGP_DBA2J_G0028515
protein coding gene Chr4:116688444-116691644 (+)
FVB/NJ MGP_FVBNJ_G0028481
protein coding gene Chr4:115207583-115209351 (+)
LP/J MGP_LPJ_G0028615
protein coding gene Chr4:120973248-120975006 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028509
protein coding gene Chr4:133718596-133720369 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029164
protein coding gene Chr4:119699237-119701005 (+)
PWK/PhJ MGP_PWKPhJ_G0027555
protein coding gene Chr4:113618246-113620007 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027381
protein coding gene Chr4:116141500-116143247 (+)
WSB/EiJ MGP_WSBEiJ_G0027912
protein coding gene Chr4:119710394-119712171 (+)



Homology
more
  • Human Ortholog
    GUCA2A, guanylate cyclase activator 2A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GUCA2A, guanylate cyclase activator 2A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GCAP-I, GUCA2, STARA
  • Links
    NCBI Gene ID: 2980
    neXtProt AC: NX_Q02747
    UniProt: Q02747

  • Chr Location
    1p34.2; chr1:42162691-42164724 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased proliferation and migration rate of colonic epithelia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14915 NCBI Gene Model | MGI Sequence Detail 1734 C57BL/6J ±  kb
    transcript NM_008190 RefSeq | MGI Sequence Detail 560 C57BL/6  
    polypeptide P33680 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 2
      cDNA 78

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19643
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:22330 Sciaky D, et al., Genomic sequence of the murine guanylin gene. Genomics. 1994 Dec;24(3):583-7
    • Latest
      J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory