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Dck
Gene Detail
Symbol

Name
ID
Dck
deoxycytidine kinase
MGI:102726
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:88764996-88783281 bp, + strand
From VEGA annotation of GRCm38

  18286 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: deoxynucleoside kinase
Gene Tree: Dck

Human
homologs
Human Homolog DCK, deoxycytidine kinase
NCBI Gene ID 1633
neXtProt AC  NX_P27707
Human Chr (Location)  4q13.3-q21.1; chr4:70993548-71030914 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have profound defects in lymphopoiesis. Thymic T cell number and overall lymphocyte number are greatly reduced.
 
Interactions
Dck interacts with 240 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process deoxycytidine metabolic process, deoxyribonucleoside monophosphate biosynthetic process, ...
Component cytosol, nucleus
Function ATP binding, deoxycytidine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025239 (Evidence)
Ensembl Gene ModelENSMUSG00000029366 (Evidence)
Entrez Gene13178 (Evidence)
EC2.7.1.74
Consensus CDS ProjectCCDS19405.1
International Mouse Knockout Project StatusDck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025239 VEGA Gene Model | MGI Sequence Detail 18286 C57BL/6J ±  kb
transcript OTTMUST00000062134 VEGA | MGI Sequence Detail 3078 Not Applicable 
polypeptide OTTMUSP00000030586 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002624 Deoxynucleoside kinase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006309 deoxycytidine kinase
References
(Earliest) J:20536 Karlsson A, et al., 2 cloning and expression of mouse deoxycytidine kinase. Pure recombinant mouse and human enzymes show differences in substrate specificity. J Biol Chem. 1994 Sep 30;269(39):24374-8
(Latest) J:190862 Austin WR, et al., Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19;209(12):2215-28
All references(35)
Other
accession IDs
MGD-MRK-19630

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory