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Polr2k Gene Detail
Summary
  • Symbol
    Polr2k
  • Name
    polymerase (RNA) II (DNA directed) polypeptide K
  • Synonyms
    ABC10-alpha, MafY, Mt1a, RPABC4, RPB10alpha, RPB12, RPB7.0
  • Feature Type
    protein coding gene
  • IDs
    MGI:102725
    NCBI Gene: 17749
  • Gene Overview
    MyGene.info: POLR2K
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr15:36174010-36177010 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 14.46 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102725
protein coding gene Chr15:36174010-36177012 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021791
protein coding gene Chr15:34552302-34555265 (+)
A/J MGP_AJ_G0021752
protein coding gene Chr15:33254737-33257733 (+)
AKR/J MGP_AKRJ_G0021730
protein coding gene Chr15:34175966-34179842 (+)
BALB/cJ MGP_BALBcJ_G0021758
protein coding gene Chr15:33262622-33265622 (+)
C3H/HeJ MGP_C3HHeJ_G0021533
protein coding gene Chr15:34145244-34148218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022197
protein coding gene Chr15:35858116-35862428 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019735
protein coding gene Chr15:31065323-31068447 (+)
CAST/EiJ MGP_CASTEiJ_G0021049
protein coding gene Chr15:34546947-34549903 (+)
CBA/J MGP_CBAJ_G0021502
protein coding gene Chr15:37021010-37024003 (+)
DBA/2J MGP_DBA2J_G0021626
protein coding gene Chr15:33077390-33080377 (+)
FVB/NJ MGP_FVBNJ_G0021604
protein coding gene Chr15:32477289-32480278 (+)
LP/J MGP_LPJ_G0021695
protein coding gene Chr15:34454403-34457286 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0022220
protein coding gene Chr15:34330486-34333485 (+)
PWK/PhJ MGP_PWKPhJ_G0020793
protein coding gene Chr15:33095517-33098614 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020631
protein coding gene Chr15:34026331-34029343 (+)
WSB/EiJ MGP_WSBEiJ_G0021105
protein coding gene Chr15:34296452-34299440 (+)



Homology
more
  • Human Ortholog
    POLR2K, RNA polymerase II subunit K
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POLR2K, RNA polymerase II subunit K
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC10-alpha, hRPB7.0, hsRPB10a, RPABC4, RPB10alpha, RPB12, RPB7.0
  • Links
    NCBI Gene ID: 5440
    neXtProt AC: NX_P53803
    UniProt: P53803

  • Chr Location
    8q22.2; chr8:100150611-100154002 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045996 Ensembl Gene Model | MGI Sequence Detail 3001 C57BL/6J ±  kb
transcript ENSMUST00000057177 Ensembl | MGI Sequence Detail 601 Not Applicable  
polypeptide ENSMUSP00000051968 Ensembl | MGI Sequence Detail 99 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR006591 RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
    IPR029040 RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Molecular
Reagents
less
  • All nucleic 38
    cDNA 36
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19629
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory