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Tpp2 Gene Detail
Summary
  • Symbol
    Tpp2
  • Name
    tripeptidyl peptidase II
  • Synonyms
    TppII
  • Feature Type
    protein coding gene
  • IDs
    MGI:102724
    NCBI Gene: 22019
  • Gene Overview
    MyGene.info: TPP2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43933865-44003000 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102724
protein coding gene Chr1:43933647-44003000 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015983
protein coding gene Chr1:42970086-43040660 (+)
A/J MGP_AJ_G0015967
protein coding gene Chr1:41635648-41704565 (+)
AKR/J MGP_AKRJ_G0015922
protein coding gene Chr1:42208397-42281463 (+)
BALB/cJ MGP_BALBcJ_G0015921
protein coding gene Chr1:41318696-41388147 (+)
C3H/HeJ MGP_C3HHeJ_G0015754
protein coding gene Chr1:42589958-42658859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016374
protein coding gene Chr1:44687145-44773897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014096
protein coding gene Chr1:38474218-38545524 (+)
CAST/EiJ MGP_CASTEiJ_G0015335
protein coding gene Chr1:42596142-42679953 (+)
CBA/J MGP_CBAJ_G0015726
protein coding gene Chr1:45997330-46072029 (+)
DBA/2J MGP_DBA2J_G0015827
protein coding gene Chr1:40926114-41009400 (+)
FVB/NJ MGP_FVBNJ_G0015829
protein coding gene Chr1:40441285-40510133 (+)
LP/J MGP_LPJ_G0015897
protein coding gene Chr1:43287582-43357946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015849
protein coding gene Chr1:47972466-48052928 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016421
protein coding gene Chr1:42428500-42501016 (+)
PWK/PhJ MGP_PWKPhJ_G0015118
protein coding gene Chr1:40813238-40884155 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014900
protein coding gene Chr1:42446532-42526109 (+)
WSB/EiJ MGP_WSBEiJ_G0015397
protein coding gene Chr1:42475874-42547534 (+)



Homology
more
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TPP-2, TPPII, TPP-II
  • Links
    NCBI Gene ID: 7174
    neXtProt AC: NX_P29144
    UniProt: P29144

  • Chr Location
    13q33.1; chr13:102596936-102679174 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22019 NCBI Gene Model | MGI Sequence Detail 69136 C57BL/6J ±  kb
transcript NM_009418 RefSeq | MGI Sequence Detail 4708 C57BL/6  
polypeptide Q64514 UniProt | EBI | MGI Sequence Detail 1262 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • EC
  • InterPro Domains
    IPR022229 Peptidase S8A, tripeptidyl peptidase II
    IPR000209 Peptidase S8/S53 domain
    IPR036852 Peptidase S8/S53 domain superfamily
    IPR022398 Peptidase S8, subtilisin, His-active site
    IPR015500 Peptidase S8, subtilisin-related
    IPR023828 Peptidase S8, subtilisin, Ser-active site
    IPR034051 Tripeptidyl-peptidase II domain
Molecular
Reagents
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  • All nucleic 185
    Genomic 1
    cDNA 184

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-19628
References
more
  • Summaries
    All 42
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:2944 Epstein DJ, et al., Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1991 Nov 15;67(4):767-74
  • Latest
    J:221205 Stepensky P, et al., Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015 Jan 29;125(5):753-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory