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Tpp2
Gene Detail
Symbol

Name
ID
Tpp2
tripeptidyl peptidase II
MGI:102724
Synonyms
TppII
Feature Type
protein coding gene
Genetic Map
Chromosome 1
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:43933647-44003000 bp, + strand
From VEGA annotation of GRCm38

  69354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TPP2
Protein SuperFamily: tripeptidyl-peptidase 2
Gene Tree: Tpp2

Human
homologs
TPP2, tripeptidyl peptidase II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7174
neXtProt AC: NX_P29144

Human Synonyms: TPP-2

Human Chr (Location): 13q32-q33; chr13:102596936-102679174 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
 
Interactions
Tpp2 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis
Component cytoplasm, nucleoplasm, ...
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(180)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TPP2 ; Xenbase tpp2    NEW 
Molecular
reagents
All nucleic(184) Genomic(1) cDNA(183)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000046400 (Evidence)
Ensembl Gene Model ENSMUSG00000041763 (Evidence)
Entrez Gene 22019 (Evidence)
UniGene 401675
DFCI TC1591894, TC1583257, TC1572421, TC1761143, TC1635234, TC1650202
DoTS DT.97380065, DT.94230263, DT.94230248, DT.91291164, DT.492359, DT.101379943, DT.101334977, DT.97380066
NIA Mouse Gene Index U000229
EC 3.4.14.10
Consensus CDS Project CCDS14926.1
International Mouse Phenotyping Consortium Status Tpp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046400 VEGA Gene Model | MGI Sequence Detail 69354 C57BL/6J ±  kb
transcript OTTMUST00000120872 VEGA | MGI Sequence Detail 4649 Not Applicable 
polypeptide OTTMUSP00000066804 VEGA | MGI Sequence Detail 1262 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(5) UniProt(9)
Polymorphisms
SNPs within 2kb(355 from dbSNP Build 137)    SNPs within 2kb including multiple locations(361)
Protein-related
information
ResourceIDDescription
InterPro IPR022229 Peptidase S8A, tripeptidyl peptidase II
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
Protein Ontology PR:000016586 tripeptidyl-peptidase 2
References
(Earliest) J:2944 Epstein DJ, et al., Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1991 Nov 15;67(4):767-74
(Latest) J:221205 Stepensky P, et al., Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015 Jan 29;125(5):753-61
All references(42)
Other
accession IDs
MGD-MRK-19628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory