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Tpp2
Gene Detail
Symbol

Name
ID
Tpp2
tripeptidyl peptidase II
MGI:102724
Synonyms
TppII
Feature Type
protein coding gene
Genetic Map
Chromosome 1
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:43933647-44003000 bp, + strand
From VEGA annotation of GRCm38

  69354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tripeptidyl-peptidase 2
Gene Tree: Tpp2

Human
homologs
Human Homolog TPP2, tripeptidyl peptidase II
NCBI Gene ID 7174
neXtProt AC  NX_P29144
Human Synonyms  TPP-2
Human Chr (Location)  13q32-q33; chr13:102596936-102679174 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
 
Interactions
Tpp2 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process proteolysis
Component cytoplasm, nucleus
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(180)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) Genomic(1) cDNA(183)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000046400 (Evidence)
Ensembl Gene ModelENSMUSG00000041763 (Evidence)
Entrez Gene22019 (Evidence)
UniGene401675
DFCITC1591894, TC1583257, TC1572421, TC1635234, TC1761143, TC1650202
DoTSDT.101334977, DT.101379943, DT.91291164, DT.492359, DT.97380066, DT.94230248, DT.97380065, DT.94230263
NIA Mouse Gene IndexU000229
EC3.4.14.10
Consensus CDS ProjectCCDS14926.1
International Mouse Knockout Project StatusTpp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046400 VEGA Gene Model | MGI Sequence Detail 69354 C57BL/6J ±  kb
transcript OTTMUST00000120872 VEGA | MGI Sequence Detail 4649 Not Applicable 
polypeptide OTTMUSP00000066804 VEGA | MGI Sequence Detail 1262 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(5) UniProt(14)
Polymorphisms
SNPs within 2kb(355 from dbSNP Build 137)    SNPs within 2kb including multiple locations(361)
Protein-related
information
ResourceIDDescription
InterPro IPR022229 Peptidase S8A, tripeptidyl peptidase II
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
Protein Ontology PR:000016586 tripeptidyl-peptidase 2
References
(Earliest) J:2944 Epstein DJ, et al., Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1991 Nov 15;67(4):767-74
(Latest) J:185084 Eklund S, et al., Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics. Biochim Biophys Acta. 2012 Apr;1824(4):561-70
All references(41)
Other
accession IDs
MGD-MRK-19628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory