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Tpp2 Gene Detail
Summary
  • Symbol
    Tpp2
  • Name
    tripeptidyl peptidase II
  • Synonyms
    TppII
  • Feature Type
    protein coding gene
  • IDs
    MGI:102724
    NCBI Gene: 22019
  • Gene Overview
    MyGene.info: TPP2
Location & Maps
more
  • Sequence Map
    Chr1:43933647-44003000 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69354 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.50 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPP2, tripeptidyl peptidase 2
    Orthology source: HomoloGene
  • Synonyms
    TPP-2, TPPII
  • Links
    NCBI Gene ID: 7174
    neXtProt AC: NX_P29144

  • Chr Location
    13q32-q33; chr13:102596936-102679174 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Targeted
    2
  • Genomic Mutations
    1 involving Tpp2
  • Incidental Mutations
Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046400 VEGA Gene Model | MGI Sequence Detail 69354 C57BL/6J ±  kb
transcript OTTMUST00000120872 VEGA | MGI Sequence Detail 4649 Not Applicable  
polypeptide OTTMUSP00000066804 VEGA | MGI Sequence Detail 1262 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    349 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000016586 tripeptidyl-peptidase 2
  • EC
  • InterPro Domains
    IPR022229 Peptidase S8A, tripeptidyl peptidase II
    IPR000209 Peptidase S8/S53 domain
    IPR022398 Peptidase S8, subtilisin, His-active site
    IPR015500 Peptidase S8, subtilisin-related
    IPR023828 Peptidase S8, subtilisin, Ser-active site
Molecular
Reagents
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  • All nucleic 184
    Genomic 1
    cDNA 183

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-19628
References
more
  • Summaries
    All 40
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:2944 Epstein DJ, et al., Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1991 Nov 15;67(4):767-74
  • Latest
    J:221205 Stepensky P, et al., Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015 Jan 29;125(5):753-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory