Pcnt
Gene Detail

Symbol Name ID

Pcnt pericentrin (kendrin) MGI:102722

Synonyms

m239Asp, m275Asp, mKIAA0402, Pcnt2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:76351254-76442912 bp, - strand From NCBI annotation of GRCm38   91659 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pcnt

Human homologs

Human Homolog		PCNT, pericentrin
NCBI Gene ID		5116
neXtProt AC		NX_O95613
Human Synonyms		KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4
Human Chr (Location)		21q22.3; chr21:47744036-47865682 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PCNT

Alleles and phenotypes

All alleles(80) : Targeted(3) Gene trapped(75) Chemically induced(2)
 

Mice homozygous for ENU mutations exhibit perinatal lethality, polydactyly, and abnormal interneuron migration. Heterozygotes exhibit sporadic seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	apoptotic process, brain morphogenesis, ...
Component	centriole, centrosome, ...
Function	calmodulin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (283)    Tissues (126)    Images (13)
Theiler Stages: 10, 13, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	217
Northern blot	25
Western blot	10
RT-PCR	24

cDNA source data(139)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(149) Genomic(3) cDNA(143) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000001151 (Evidence)
Entrez Gene	18541 (Evidence)
UniGene	251794
DFCI	TC1582108, TC1601047, TC1634683, TC1677014, TC1711670
DoTS	DT.101312018, DT.101313120, DT.94193856, DT.97361945, DT.99842032
Consensus CDS Project	CCDS23944.1
International Mouse Knockout Project Status	Pcnt

Sequences

Length	Strain/Species
genomic	18541	NCBI Gene Model | MGI Sequence Detail	91659	C57BL/6J
transcript	NM_008787	RefSeq | MGI Sequence Detail	9530	C57BL/6
polypeptide	P48725	UniProt | EBI | MGI Sequence Detail	2898	Not Applicable

All sequences(54) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(146 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024151	Pericentrin
InterPro	IPR019528	Pericentrin/AKAP-450 centrosomal targeting domain
Protein Ontology	PR:000012423	pericentrin

Graphical View of Protein Domain Structure

References

(Earliest) J:17138 Doxsey SJ, et al., Pericentrin, a highly conserved centrosome protein involved in microtubule organization [see comments]. Cell. 1994 Feb 25;76(4):639-50
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(92)

Other accession IDs

MGD-MRK-19626, MGI:2143839, MGI:2143946, MGI:3799283, MGI:3799287