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Pcnt
Gene Detail
Symbol

Name
ID
Pcnt
pericentrin (kendrin)
MGI:102722
Synonyms
m239Asp, m275Asp, mKIAA0402, Pcnt2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:76351254-76442912 bp, - strand
From Ensembl annotation of GRCm38

  91659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: PCNT
Gene Tree: Pcnt
Human
homologs
PCNT, pericentrin
Orthology source: HGNC

IDs:
NCBI Gene ID: 5116
neXtProt AC: NX_O95613

Human Synonyms: KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4

Human Chr (Location): 21q22.3; chr21:46324100-46445769 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PCNT

Mutations,
alleles, and
phenotypes
All mutations/alleles(84) : Chemically induced (ENU)(2) Gene trapped(75) Targeted(7)
Genomic Mutations involving Pcnt (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for ENU mutations exhibit perinatal lethality, polydactyly, and abnormal interneuron migration. Heterozygotes exhibit sporadic seizures.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Pcnt interacts with 142 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process brain morphogenesis, cerebellar cortex morphogenesis, ...
Component centriole, centrosome, ...
Function calmodulin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (315)    Tissues (134)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 217
Northern blot 25
Western blot 10
RT-PCR 24
cDNA source data(139)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pcnt ; ZFIN pcnt    NEW 
Molecular
reagents
All nucleic(149) Genomic(3) cDNA(143) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000001151 (Evidence)
Entrez Gene 18541 (Evidence)
UniGene 251794
DFCI TC1582108, TC1601047, TC1634683, TC1677014, TC1711670
DoTS DT.101312018, DT.101313120, DT.94193856, DT.97361945, DT.99842032
Consensus CDS Project CCDS23944.1
International Mouse Phenotyping Consortium Status Pcnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001151 Ensembl Gene Model | MGI Sequence Detail 91659 C57BL/6J ±  kb
transcript ENSMUST00000001179 Ensembl | MGI Sequence Detail 9530 Not Applicable 
polypeptide ENSMUSP00000001179 Ensembl | MGI Sequence Detail 2916 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(22) UniProt(9)
Polymorphisms
SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024151 Pericentrin
InterPro IPR019528 Pericentrin/AKAP-450 centrosomal targeting domain
Protein Ontology PR:000012423 pericentrin
References
(Earliest) J:17138 Doxsey SJ, et al., Pericentrin, a highly conserved centrosome protein involved in microtubule organization [see comments]. Cell. 1994 Feb 25;76(4):639-50
(Latest) J:219422 Insolera R, et al., Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014 Nov;17(11):1528-35
All references(103)
Other
accession IDs
MGD-MRK-19626, MGI:2143839, MGI:2143946, MGI:3799283, MGI:3799287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory