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Pcnt
Gene Detail
 Symbol
Name
ID
Pcnt
pericentrin (kendrin)
MGI:102722
Synonyms m239Asp, m275Asp, mKIAA0402, Pcnt2
Feature Type protein coding gene
Genetic Map
Chromosome 10
38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:76351254-76442912 bp, - strand
From NCBI annotation of GRCm38

  91659 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Gene Tree: Pcnt
Mutations,
alleles, and
phenotypes
All mutations/alleles(84) : Chemically induced (ENU)(2) Gene trapped(75) Targeted(7)
Genomic Mutations involving Pcnt (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for ENU mutations exhibit perinatal lethality, polydactyly, and abnormal interneuron migration. Heterozygotes exhibit sporadic seizures.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Pcnt interacts with 142 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process brain morphogenesis, cerebellar cortex morphogenesis, ...
Component centriole, centrosome, ...
Function calmodulin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (283)    Tissues (126)    Images (13)
Theiler Stages: 10, 13, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 217
Northern blot 25
Western blot 10
RT-PCR 24
cDNA source data(139)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(149) Genomic(3) cDNA(143) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000001151 (Evidence)
Entrez Gene18541 (Evidence)
UniGene251794
DFCITC1582108, TC1601047, TC1634683, TC1677014, TC1711670
DoTSDT.101312018, DT.101313120, DT.94193856, DT.97361945, DT.99842032
Consensus CDS ProjectCCDS23944.1
International Mouse Knockout Project StatusPcnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18541 NCBI Gene Model | MGI Sequence Detail 91659 C57BL/6J ±  kb
transcript NM_008787 RefSeq | MGI Sequence Detail 9530 C57BL/6 
polypeptide P48725 UniProt | EBI | MGI Sequence Detail 2898 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(30) UniProt(9)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024151 Pericentrin
InterPro IPR019528 Pericentrin/AKAP-450 centrosomal targeting domain
Protein Ontology PR:000012423 pericentrin
Graphical View of Protein Domain Structure
References (Earliest) J:17138 Doxsey SJ, et al., Pericentrin, a highly conserved centrosome protein involved in microtubule organization [see comments]. Cell. 1994 Feb 25;76(4):639-50
(Latest) J:208632 Bazzi H, et al., Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
All references(100)
Other
accession IDs
MGD-MRK-19626, MGI:2143839, MGI:2143946, MGI:3799283, MGI:3799287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory