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Cryba4 Gene Detail
Summary
  • Symbol
    Cryba4
  • Name
    crystallin, beta A4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102716
    NCBI Gene: 12959
  • Gene Overview
    MyGene.info: CRYBA4
Location & Maps
more
  • Sequence Map
    Chr5:112246493-112252518 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6026 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 54.62 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CRYBA4, crystallin beta A4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYBA4, crystallin beta A4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRCT23, CYRBA4, MCOPCT4
  • Links
    NCBI Gene ID: 1413
    neXtProt AC: NX_P53673

  • Chr Location
    22q12.1; chr22:26607987-26630672 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CRYBA4 associations

Human Disease Mouse Models
       Cataract 23; CTRCT23   OMIM: 610425
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Cryba4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021278 VEGA Gene Model | MGI Sequence Detail 6026 C57BL/6J ±  kb
transcript OTTMUST00000050446 VEGA | MGI Sequence Detail 808 Not Applicable  
polypeptide OTTMUSP00000023541 VEGA | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    Genomic 1
    cDNA 84
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19620
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:23156 Hulsebos TJ, et al., The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995 Jan 20;25(2):574-6
  • Latest
    J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory