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Cryba4
Gene Detail
Symbol

Name
ID
Cryba4
crystallin, beta A4
MGI:102716
Feature Type
protein coding gene
Genetic Map
Chromosome 5
54.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:112246493-112252518 bp, - strand
From VEGA annotation of GRCm38

  6026 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRYBA4
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryba4

Human
homologs
CRYBA4, crystallin, beta A4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1413
neXtProt AC: NX_P53673

Human Synonyms: CTRCT23, MCOPCT4

Human Chr (Location): 22q12.1; chr22:26607987-26630672 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYBA4

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cryba4 interacts with 19 markers (Mir19b-1, Mir23a, Mir291a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process camera-type eye development, visual perception
Function structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (12)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 12
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cryba4 ; ZFIN cryba4    NEW 
Molecular
reagents
All nucleic(87) Genomic(1) cDNA(84) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021278 (Evidence)
Ensembl Gene Model ENSMUSG00000066975 (Evidence)
Entrez Gene 12959 (Evidence)
UniGene 40324
DFCI TC1577603
DoTS DT.55140408, DT.99846602
NIA Mouse Gene Index U015064
Consensus CDS Project CCDS19536.1
International Mouse Phenotyping Consortium Status Cryba4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021278 VEGA Gene Model | MGI Sequence Detail 6026 C57BL/6J ±  kb
transcript OTTMUST00000050446 VEGA | MGI Sequence Detail 808 Not Applicable 
polypeptide OTTMUSP00000023541 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005910 beta-crystallin A4
References
(Earliest) J:23156 Hulsebos TJ, et al., The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995 Jan 20;25(2):574-6
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(37)
Other
accession IDs
MGD-MRK-19620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory