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Efnb1
Gene Detail
Symbol

Name
ID
Efnb1
ephrin B1
MGI:102708
Synonyms
Cek5-L, Cek5 ligand, EFL-3, Elk-L, Epl2, Eplg2, Lerk2, LERK-2, Stra1
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.22 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:99136130-99148991 bp, + strand
From VEGA annotation of GRCm38

  12862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EFNB1
Protein SuperFamily: Ephrin-B
Gene Tree: Efnb1

Human
homologs
EFNB1, ephrin-B1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1947
neXtProt AC: NX_P98172

Human Synonyms: CFND, CFNS, EFB1, EFL3, Elk-L, EPLG2, LERK2

Human Chr (Location): Xq12; chrX:68828997-68842164 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EFNB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Engineered alleles of this gene produce cranialfacial defects resulting in neonatal lethality.
 
Human Diseases Modeled in Mice Using Efnb1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Efnb1 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axon guidance, cell differentiation, ...
Component cytoplasm, extracellular exosome, ...
Function ephrin receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (79 records)
Data Summary: Results (613)    Tissues (382)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 575
Northern blot 8
Western blot 5
RT-PCR 12
cDNA source data(78)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EFNB1 ; Xenbase efnb1 ; ZFIN efnb1    NEW 
Molecular
reagents
All nucleic(92) Genomic(6) cDNA(81) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018065 (Evidence)
Ensembl Gene Model ENSMUSG00000031217 (Evidence)
Entrez Gene 13641 (Evidence)
UniGene 3374
DFCI TC1577681
DoTS DT.531569
NIA Mouse Gene Index U020045
Consensus CDS Project CCDS30298.1
International Mouse Phenotyping Consortium Status Efnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018065 VEGA Gene Model | MGI Sequence Detail 12862 C57BL/6J ±  kb
transcript OTTMUST00000043596 VEGA | MGI Sequence Detail 3258 Not Applicable 
polypeptide OTTMUSP00000019590 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006921 ephrin-B1
References
(Earliest) J:21114 Shao H, et al., cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem. 1994 Oct 28;269(43):26606-9
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(133)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19612

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory