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Efnb1
Gene Detail
Symbol

Name
ID
Efnb1
ephrin B1
MGI:102708
Synonyms
Cek5-L, Cek5 ligand, EFL-3, Elk-L, Epl2, Eplg2, Lerk2, LERK-2, Stra1
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.22 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:99136130-99148991 bp, + strand
From VEGA annotation of GRCm38

  12862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ephrin-B
Gene Tree: Efnb1

Human
homologs
Human Homolog EFNB1, ephrin-B1
NCBI Gene ID 1947
neXtProt AC  NX_P98172
Human Synonyms  CFND, CFNS, EFB1, EFL3, Elk-L, EPLG2, LERK2
Human Chr (Location)  Xq12; chrX:68828997-68842164 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EFNB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Engineered alleles of this gene produce cranialfacial defects resulting in neonatal lethality.
 
Human Diseases Modeled Using Mouse Efnb1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Efnb1 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axon guidance, cell differentiation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function ephrin receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (613)    Tissues (382)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 575
Northern blot 8
Western blot 5
RT-PCR 12
cDNA source data(78)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(6) cDNA(81) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000018065 (Evidence)
Ensembl Gene ModelENSMUSG00000031217 (Evidence)
Entrez Gene13641 (Evidence)
UniGene3374
DFCITC1577681
DoTSDT.531569
NIA Mouse Gene IndexU020045
Consensus CDS ProjectCCDS30298.1
International Mouse Knockout Project StatusEfnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018065 VEGA Gene Model | MGI Sequence Detail 12862 C57BL/6J ±  kb
transcript OTTMUST00000043596 VEGA | MGI Sequence Detail 3258 Not Applicable 
polypeptide OTTMUSP00000019590 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006921 ephrin-B1
References
(Earliest) J:21114 Shao H, et al., cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem. 1994 Oct 28;269(43):26606-9
(Latest) J:212953 Arvanitis DN, et al., Cortical abnormalities and non-spatial learning deficits in a mouse model of CranioFrontoNasal syndrome. PLoS One. 2014;9(2):e88325
All references(130)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19612

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory