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Efna2
Gene Detail
Symbol

Name
ID
Efna2
ephrin A2
MGI:102707
Synonyms
Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:80179482-80190010 bp, + strand
From VEGA annotation of GRCm38

  10529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EFNA2
Protein SuperFamily: Ephrin-A
Gene Tree: Efna2

Human
homologs
EFNA2, ephrin-A2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1943
neXtProt AC: NX_O43921

Human Synonyms: ELF-1, EPLG6, HEK7-L, LERK6, LERK-6

Human Chr (Location): 19p13.3; chr19:1286154-1301431 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from CvDC )
 
Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus
 
Mutations Annotated to Human Diseases (1)   
Interactions
Efna2 interacts with 147 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon guidance, bone remodeling, ...
Component anchored component of membrane, membrane, ...
Function ephrin receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (175)    Tissues (151)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 155
RT-PCR 18
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase efna2 ; ZFIN efna2a    NEW 
Molecular
reagents
All nucleic(35) cDNA(30) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000009 (Evidence)
Ensembl Gene Model ENSMUSG00000003070 (Evidence)
Entrez Gene 13637 (Evidence)
UniGene 1478
DFCI TC1583365, TC1686563
DoTS DT.101724402, DT.91412546, DT.488241
NIA Mouse Gene Index U011743
Consensus CDS Project CCDS24013.1
International Mouse Phenotyping Consortium Status Efna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000009 VEGA Gene Model | MGI Sequence Detail 10529 C57BL/6J ±  kb
transcript OTTMUST00000045722 VEGA | MGI Sequence Detail 2131 Not Applicable 
polypeptide OTTMUSP00000020589 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006917 ephrin-A2
References
(Earliest) J:20670 Cheng HJ, et al., Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 7;79(1):157-68
(Latest) J:217214 Yates NJ, et al., The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating. Behav Brain Res. 2014 Dec 15;275:225-33
All references(110)
Other
accession IDs
MGD-MRK-19611

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory