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Efna2
Gene Detail
Symbol

Name
ID
Efna2
ephrin A2
MGI:102707
Synonyms
Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:80179482-80190010 bp, + strand
From VEGA annotation of GRCm38

  10529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Ephrin-A
Gene Tree: Efna2

Human
homologs
Human Homolog EFNA2, ephrin-A2
NCBI Gene ID 1943
neXtProt AC  NX_O43921
Human Synonyms  ELF-1, EPLG6, HEK7-L, LERK6, LERK-6
Human Chr (Location)  19p13.3; chr19:1286154-1301431 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
 
Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus
 
Interactions
Efna2 interacts with 148 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon guidance, bone remodeling, ...
Component anchored component of membrane, membrane, ...
Function ephrin receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (175)    Tissues (151)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 155
RT-PCR 18
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(30) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000009 (Evidence)
Ensembl Gene ModelENSMUSG00000003070 (Evidence)
Entrez Gene13637 (Evidence)
UniGene1478
DFCITC1686563, TC1583365
DoTSDT.91412546, DT.488241, DT.101724402
NIA Mouse Gene IndexU011743
Consensus CDS ProjectCCDS24013.1
International Mouse Knockout Project StatusEfna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000009 VEGA Gene Model | MGI Sequence Detail 10529 C57BL/6J ±  kb
transcript OTTMUST00000045722 VEGA | MGI Sequence Detail 2131 Not Applicable 
polypeptide OTTMUSP00000020589 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006917 ephrin-A2
References
(Earliest) J:20670 Cheng HJ, et al., Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 7;79(1):157-68
(Latest) J:206575 Steinecke A, et al., EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development. 2014 Jan;141(2):460-71
All references(109)
Other
accession IDs
MGD-MRK-19611

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory