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Efna2 Gene Detail
Summary
  • Symbol
    Efna2
  • Name
    ephrin A2
  • Synonyms
    Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:102707
    NCBI Gene: 13637
  • Gene Overview
    MyGene.info: EFNA2
Location & Maps
more
  • Sequence Map
    Chr10:80179482-80190010 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10529 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EFNA2, ephrin A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EFNA2, ephrin A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ELF-1, EPLG6, HEK7-L, LERK6, LERK-6
  • Links
    NCBI Gene ID: 1943
    neXtProt AC: NX_O43921

  • Chr Location
    19p13.3; chr19:1286154-1301431 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    5
  • Genomic Mutations
    1 involving Efna2
  • Incidental Mutations
Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000009 VEGA Gene Model | MGI Sequence Detail 10529 C57BL/6J ±  kb
transcript OTTMUST00000045722 VEGA | MGI Sequence Detail 2131 Not Applicable  
polypeptide OTTMUSP00000020589 VEGA | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    19 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 30
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19611
References
more
  • Summaries
    All 111
    Developmental Gene Expression 49
    Diseases 1
    Gene Ontology 8
    Phenotypes 39
  • Earliest
    J:20670 Cheng HJ, et al., Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 7;79(1):157-68
  • Latest
    J:231672 Xavier GM, et al., Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory