Efna2
Gene Detail

Symbol Name ID

Efna2 ephrin A2 MGI:102707

Synonyms

Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:80179482-80190010 bp, + strand From VEGA annotation of GRCm38   10529 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: Ephrin-A
Gene Tree: Efna2

Human homologs

Human Homolog		EFNA2, ephrin-A2
NCBI Gene ID		1943
neXtProt AC		NX_O43921
Human Synonyms		ELF-1, EPLG6, HEK7-L, LERK6, LERK-6
Human Chr (Location)		19p13.3; chr19:1286153-1301430 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(4) Gene trapped(8)
 

Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	bone remodeling, ephrin receptor signaling pathway, ...
Component	anchored to membrane, membrane, ...
Function	ephrin receptor binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (158)    Tissues (136)    Images (36)
Theiler Stages: 13, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	146
RT-PCR	12

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) cDNA(30) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000009 (Evidence)
Ensembl Gene Model	ENSMUSG00000003070 (Evidence)
Entrez Gene	13637 (Evidence)
UniGene	1478
DFCI	TC1583365, TC1686563
DoTS	DT.101724402, DT.488241, DT.91412546
NIA Mouse Gene Index	U011743
Consensus CDS Project	CCDS24013.1
International Mouse Knockout Project Status	Efna2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000009	VEGA Gene Model | MGI Sequence Detail	10529	C57BL/6J
transcript	OTTMUST00000045722	VEGA | MGI Sequence Detail	2131	Not Applicable
polypeptide	OTTMUSP00000020589	VEGA | MGI Sequence Detail	209	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008972	Cupredoxin
InterPro	IPR001799	Ephrin
InterPro	IPR019765	Ephrin, conserved site
Protein Ontology	PR:000006917	ephrin-A2

References

(Earliest) J:20670 Cheng HJ, et al., Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 1994 Oct 7;79(1):157-68
(Latest) J:195031 Makowiecki K, et al., Different levels of food restriction reveal genotype-specific differences in learning a visual discrimination task. PLoS One. 2012;7(11):e48703
All references(103)

Other accession IDs

MGD-MRK-19611