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Fdft1 Gene Detail
Summary
  • Symbol
    Fdft1
  • Name
    farnesyl diphosphate farnesyl transferase 1
  • Synonyms
    SQS, squalene synthase, Ss
  • Feature Type
    protein coding gene
  • IDs
    MGI:102706
    NCBI Gene: 14137
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63145150-63179578 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102706
 protein coding gene Chr14:63145150-63181687 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021457
 protein coding gene Chr14:57636810-57668383 (-)
A/J MGP_AJ_G0021416
 protein coding gene Chr14:56338708-56375120 (-)
AKR/J MGP_AKRJ_G0021392
 protein coding gene Chr14:58349580-58384332 (-)
BALB/cJ MGP_BALBcJ_G0021422
 protein coding gene Chr14:56297574-56328954 (-)
C3H/HeJ MGP_C3HHeJ_G0021199
 protein coding gene Chr14:57964360-57998764 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021861
 protein coding gene Chr14:60391854-60425117 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019401
 protein coding gene Chr14:54303494-54333563 (-)
CAST/EiJ MGP_CASTEiJ_G0020716
 protein coding gene Chr14:54420429-54452459 (-)
CBA/J MGP_CBAJ_G0021166
 protein coding gene Chr14:62176426-62217702 (-)
DBA/2J MGP_DBA2J_G0021289
 protein coding gene Chr14:55994237-56057491 (-)
FVB/NJ MGP_FVBNJ_G0021268
 protein coding gene Chr14:55411732-55442072 (-)
LP/J MGP_LPJ_G0021364
 protein coding gene Chr14:58663852-58700667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021297
 protein coding gene Chr14:61445455-61481734 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021884
 protein coding gene Chr14:57493453-57526128 (-)
PWK/PhJ MGP_PWKPhJ_G0020460
 protein coding gene Chr14:52683202-52717652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020293
 protein coding gene Chr14:53467772-53498321 (-)
WSB/EiJ MGP_WSBEiJ_G0020769
 protein coding gene Chr14:57816769-57851383 (-)



Homology
more
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGPT, ERG9, SQS, SQSD, SS
  • Links
    NCBI Gene ID: 2222
    neXtProt AC: NX_P37268
    UniProt: P37268

  • Chr Location
    8p23.1; chr8:11795573-11839309 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die around E9.5-10.5. Conditional homozygous null in which the gene is deleted specifically in oligodendrocyte and Schwann cell display dysmyelination of spinal cord and brain white matter, and showed ataxia and tremor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    339
  • Tissues
    135
  • cDNA Data
    109
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021273 Ensembl Gene Model | MGI Sequence Detail 34429 C57BL/6J ±  kb
    transcript ENSMUST00000238526 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000158805 Ensembl | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19610
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:17237 Schechter I, et al., Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. Genomics. 1994 Mar 1;20(1):116-8
    • Latest
      J:272610 Kim M, et al., Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells. Genes Dev. 2018 May 1;32(9-10):645-657
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory