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Fdft1 Gene Detail
Summary
  • Symbol
    Fdft1
  • Name
    farnesyl diphosphate farnesyl transferase 1
  • Synonyms
    SQS, squalene synthase, Ss
  • Feature Type
    protein coding gene
  • IDs
    MGI:102706
    NCBI Gene: 14137
Location & Maps
more
  • Sequence Map
    Chr14:63145153-63177793 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32641 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
    Orthology source: HomoloGene
  • Synonyms
    DGPT, ERG9, SQS, SS
  • Links
    NCBI Gene ID: 2222
    neXtProt AC: NX_P37268

  • Chr Location
    8p23.1-p22; chr8:11795573-11839309 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    29
  • Targeted
    4
  • Genomic Mutations
    1 involving Fdft1
  • Incidental Mutations
Mice homozygous for a null mutation die around E9.5-10.5. Conditional homozygous null in which the gene is deleted specifically in oligodendrocyte and Schwann cell display dysmyelination of spinal cord and brain white matter, and showed ataxia and tremor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021273 Ensembl Gene Model | MGI Sequence Detail 32641 C57BL/6J ±  kb
transcript ENSMUST00000054963 Ensembl | MGI Sequence Detail 2860 Not Applicable  
polypeptide ENSMUSP00000055313 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    172 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 112
    cDNA 110
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19610
References
more
  • Summaries
    All 52
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 19
  • Earliest
    J:17237 Schechter I, et al., Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. Genomics. 1994 Mar 1;20(1):116-8
  • Latest
    J:224387 Sisecioglu M, et al., A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory