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Fdft1 Gene Detail
Summary
  • Symbol
    Fdft1
  • Name
    farnesyl diphosphate farnesyl transferase 1
  • Synonyms
    SQS, squalene synthase, Ss
  • Feature Type
    protein coding gene
  • IDs
    MGI:102706
    NCBI Gene: 14137
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:63145150-63179578 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34429 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DGPT, ERG9, SQS, SS
  • Links
    NCBI Gene ID: 2222
    neXtProt AC: NX_P37268
    UniProt: P37268

  • Chr Location
    8p23.1; chr8:11795573-11839309 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die around E9.5-10.5. Conditional homozygous null in which the gene is deleted specifically in oligodendrocyte and Schwann cell display dysmyelination of spinal cord and brain white matter, and showed ataxia and tremor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    339
  • Tissues
    135
  • cDNA Data
    109
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021273 Ensembl Gene Model | MGI Sequence Detail 34429 C57BL/6J ±  kb
    transcript ENSMUST00000054963 Ensembl | MGI Sequence Detail 2860 Not Applicable  
    polypeptide ENSMUSP00000055313 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      172 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19610
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:17237 Schechter I, et al., Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. Genomics. 1994 Mar 1;20(1):116-8
    • Latest
      J:256230 Shin SW, et al., Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory