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Gng2
Gene Detail
Symbol

Name
ID
Gng2
guanine nucleotide binding protein (G protein), gamma 2
MGI:102705
Synonyms
1110003P13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
11.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:19872559-19977627 bp, - strand
From VEGA annotation of GRCm38

  105069 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GNG2
Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng2

Human
homologs
GNG2, guanine nucleotide binding protein (G protein), gamma 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 54331
neXtProt AC: NX_P59768

Human Chr (Location): 14q21; chr14:51847131-51969800 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Gene trapped(68) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced vomeronasal basal neurons, reduced posterior glomerular layer of the accessory olfactory bulb and decreased aggression towards male mice.
 
Interactions
Gng2 interacts with 323 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (124)    Tissues (52)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
RT-PCR 7
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gng2    NEW 
Molecular
reagents
All nucleic(86) Genomic(1) cDNA(84) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000034627 (Evidence)
Ensembl Gene Model ENSMUSG00000043004 (Evidence)
Entrez Gene 14702 (Evidence)
UniGene 41737
DFCI TC1578816, TC1715923, TC1600613, TC1697889, TC1695665
DoTS DT.97373136, DT.101394493, DT.97363297, DT.94291796
NIA Mouse Gene Index U015357, U229673, U035268
Consensus CDS Project CCDS26840.1
International Mouse Phenotyping Consortium Status Gng2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034627 VEGA Gene Model | MGI Sequence Detail 105069 C57BL/6J ±  kb
transcript OTTMUST00000087881 VEGA | MGI Sequence Detail 572 Not Applicable 
polypeptide OTTMUSP00000047864 VEGA | MGI Sequence Detail 71 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(460 from dbSNP Build 137)    SNPs within 2kb including multiple locations(466)
Protein-related
information
ResourceIDDescription
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR001770 G-protein, gamma subunit
Protein Ontology PR:000008107 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
References
(Earliest) J:14624 Hurley JB, et al., Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A. 1984 Nov;81(22):6948-52
(Latest) J:175792 Jelcick AS, et al., Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One. 2011;6(7):e21858
All references(47)
Other
accession IDs
MGD-MRK-19609, MGI:1923542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory