Gng3
Gene Detail

Symbol Name ID

Gng3 guanine nucleotide binding protein (G protein), gamma 3 MGI:102704

Synonyms

83

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:8836929-8839246 bp, - strand From NCBI annotation of GRCm38   2318 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng3

Human homologs

Human Homolog		GNG3, guanine nucleotide binding protein (G protein), gamma 3
NCBI Gene ID		2785
neXtProt AC		NX_P63215
Human Chr (Location)		11p11; chr11:62475066-62476678 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(4) Gene trapped(20)
 

Homozygous null mice display handling- and noise-induced seizures resulting in premature death and reduced growth. Female homozygotes also display reduced inguinal and retroperitoneal fat pads.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	heterotrimeric G-protein complex, membrane, ...
Function	G-protein coupled receptor binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (163)    Tissues (47)    Images (30)
Theiler Stages: 1, 2, 3, 4, 19, 23, 28

Assay Type	Results
RNA in situ	153
RT-PCR	10

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(3) cDNA(10) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000071658 (Evidence)
Entrez Gene	14704 (Evidence)
NIA Mouse Gene Index	U038781
Consensus CDS Project	CCDS29550.1
International Mouse Knockout Project Status	Gng3

Sequences

Length	Strain/Species
genomic	14704	NCBI Gene Model | MGI Sequence Detail	2318	C57BL/6J
transcript	NM_010316	RefSeq | MGI Sequence Detail	1699	C57BL/6
polypeptide	P63216	UniProt | EBI | MGI Sequence Detail	75	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015898	G-protein gamma-like domain
InterPro	IPR001770	G-protein, gamma subunit
Protein Ontology	PR:000008108	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Graphical View of Protein Domain Structure

References

(Earliest) J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
(Latest) J:182775 Schwindinger WF, et al., Synergistic roles for G-protein gamma3 and gamma7 subtypes in seizure susceptibility as revealed in double knock-out mice. J Biol Chem. 2012 Mar 2;287(10):7121-33
All references(39)

Other accession IDs

MGD-MRK-19608