About   Help   FAQ
Gng3
Gene Detail
Symbol

Name
ID
Gng3
guanine nucleotide binding protein (G protein), gamma 3
MGI:102704
Synonyms
83
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8836929-8839246 bp, - strand
From NCBI annotation of GRCm38

  2318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNG3
Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng3

Human
homologs
GNG3, guanine nucleotide binding protein (G protein), gamma 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2785
neXtProt AC: NX_P63215

Human Chr (Location): 11p11; chr11:62706422-62709206 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
 
Homozygous null mice display handling- and noise-induced seizures resulting in premature death and reduced growth. Female homozygotes also display reduced inguinal and retroperitoneal fat pads.
 
Interactions
Gng3 interacts with 152 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (160)    Tissues (44)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
RT-PCR 7
cDNA source data(65)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gng3 ; ZFIN gng3    NEW 
Molecular
reagents
All nucleic(69) Genomic(3) cDNA(65) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000071658 (Evidence)
Entrez Gene 14704 (Evidence)
UniGene 329700
NIA Mouse Gene Index U038781
Consensus CDS Project CCDS29550.1
International Mouse Phenotyping Consortium Status Gng3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14704 NCBI Gene Model | MGI Sequence Detail 2318 C57BL/6J ±  kb
transcript NM_010316 RefSeq | MGI Sequence Detail 1699 C57BL/6 
polypeptide P63216 UniProt | EBI | MGI Sequence Detail 75 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR001770 G-protein, gamma subunit
Protein Ontology PR:000008108 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Graphical View of Protein Domain Structure
References
(Earliest) J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
(Latest) J:215128 Moon AM, et al., Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970
All references(41)
Other
accession IDs
MGD-MRK-19608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory