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Gng3
Gene Detail
 Symbol
Name
ID
Gng3
guanine nucleotide binding protein (G protein), gamma 3
MGI:102704
Synonyms 83
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8836929-8839246 bp, - strand
From NCBI annotation of GRCm38

  2318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng3

Human
homologs
Human Homolog GNG3, guanine nucleotide binding protein (G protein), gamma 3
NCBI Gene ID 2785
neXtProt AC  NX_P63215
Human Chr (Location)  11p11; chr11:62706687-62709206 (+)  GRCh38
Alleles
and
phenotypes
All alleles(24) : Targeted(4) Gene trapped(20)
 
Homozygous null mice display handling- and noise-induced seizures resulting in premature death and reduced growth. Female homozygotes also display reduced inguinal and retroperitoneal fat pads.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process G-protein coupled receptor signaling pathway, GTP catabolic process, ...
Component heterotrimeric G-protein complex, membrane, ...
Function G-protein coupled receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (163)    Tissues (47)    Images (30)
Theiler Stages: 1, 2, 3, 4, 19, 23, 28
Assay TypeResults
RNA in situ 153
RT-PCR 10
cDNA source data(65)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(69) Genomic(3) cDNA(65) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000071658 (Evidence)
Entrez Gene14704 (Evidence)
UniGene329700
NIA Mouse Gene IndexU038781
Consensus CDS ProjectCCDS29550.1
International Mouse Knockout Project StatusGng3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14704 NCBI Gene Model | MGI Sequence Detail 2318 C57BL/6J ±  kb
transcript NM_010316 RefSeq | MGI Sequence Detail 1699 C57BL/6 
polypeptide P63216 UniProt | EBI | MGI Sequence Detail 75 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR001770 G-protein, gamma subunit
Protein Ontology PR:000008108 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Graphical View of Protein Domain Structure
References (Earliest) J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
(Latest) J:182775 Schwindinger WF, et al., Synergistic roles for G-protein gamma3 and gamma7 subtypes in seizure susceptibility as revealed in double knock-out mice. J Biol Chem. 2012 Mar 2;287(10):7121-33
All references(40)
Other
accession IDs
MGD-MRK-19608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory